2024
DOI: 10.3390/ijms252111401
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HIV Protein Nef Induces Cardiomyopathy Through Induction of Bcl2 and p21

Olena Kondrachuck,
Pierce Ciccone,
Nicole Ford
et al.

Abstract: HIV-associated cardiovascular diseases remain a leading cause of death in people living with HIV/AIDS (PLWHA). Although antiretroviral drugs suppress the viral load, they fail to remove the virus entirely. HIV-1 Nef protein is known to play a role in viral virulence and HIV latency. Expression of Nef protein can be detected in different organs, including cardiac tissue. Despite the established role of Nef protein in HIV-1 replication, its impact on organ function inside the human body is not clear. To understa… Show more

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