HIV-related bronchopulmonary infection by pseudomonas aeruginosa in the HAART era: radiological findings

Rizzi, Elisa Busi; Schininà, Vincenzo; Bordi, E.; Buontempo, G.; Narciso, Pasquale; Bibbolino, Corrado

doi:10.1080/02841850600827569

Cited by 8 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although P. aeruginosa bacteraemia has been reported in patients with AIDS [258][259][260], it is not the most common pathogen in such cases [261,262]. P. aeruginosa, however, is one of the leading causes of pneumonia [263,264] and a prevalent respiratory pathogen in patients with AIDS, where it often leads to chronic and intractable infections [265,266]. Before 1968, P. aeruginosa bacteraemia in cancer patients resulted in ∼80-90 % fatalities [267][268][269].…”

Section: Infections In Immunocompromised Patientsmentioning

confidence: 99%

Genomic and metabolic versatility of Pseudomonas aeruginosa contributes to its inter-kingdom transmission and survival

Ambreetha,

Zincke,

Balachandar

et al. 2024

Journal of Medical Microbiology

View full text Add to dashboard Cite

Pseudomonas aeruginosa is one of the most versatile bacteria with renowned pathogenicity and extensive drug resistance. The diverse habitats of this bacterium include fresh, saline and drainage waters, soil, moist surfaces, taps, showerheads, pipelines, medical implants, nematodes, insects, plants, animals, birds and humans. The arsenal of virulence factors produced by P. aeruginosa includes pyocyanin, rhamnolipids, siderophores, lytic enzymes, toxins and polysaccharides. All these virulent elements coupled with intrinsic, adaptive and acquired antibiotic resistance facilitate persistent colonization and lethal infections in different hosts. To date, treating pulmonary diseases remains complicated due to the chronic secondary infections triggered by hospital-acquired P. aeruginosa. On the contrary, this bacterium can improve plant growth by suppressing phytopathogens and insects. Notably, P. aeruginosa is one of the very few bacteria capable of trans-kingdom transmission and infection. Transfer of P. aeruginosa strains from plant materials to hospital wards, animals to humans, and humans to their pets occurs relatively often. Recently, we have identified that plant-associated P. aeruginosa strains could be pathologically similar to clinical isolates. In this review, we have highlighted the genomic and metabolic factors that facilitate the dominance of P. aeruginosa across different biological kingdoms and the varying roles of this bacterium in plant and human health.

show abstract

Section: Infections In Immunocompromised Patientsmentioning

confidence: 99%

Genomic and metabolic versatility of Pseudomonas aeruginosa contributes to its inter-kingdom transmission and survival

Ambreetha,

Zincke,

Balachandar

et al. 2024

Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“… Pseudomonas aeruginosa resides in diverse environmental niches, but is mostly known as a human opportunistic pathogen that infects individuals with a variety of underlying medical conditions, including cystic fibrosis (CF) [1], HIV-1 [2] and causes severe corneal and urinary tract infections [3, 4]. In 2017, the Centers for Disease Control (CDC) recognized multi-drug-resistant P.…”

Section: Introductionmentioning

confidence: 99%

carP, encoding a Ca2+-regulated putative phytase, is evolutionarily conserved in Pseudomonas aeruginosa and has potential as a biomarker

et al. 2021

View full text Add to dashboard Cite

Pseudomonas aeruginosa infects patients with cystic fibrosis, burns, wounds and implants. Previously, our group showed that elevated Ca2+ positively regulates the production of several virulence factors in P. aeruginosa , such as biofilm formation, production of pyocyanin and secreted proteases. We have identified a Ca2+-regulated β-propeller putative phytase, CarP, which is required for Ca2+ tolerance, regulation of the intracellular Ca2+ levels, and plays a role in Ca2+ regulation of P. aeruginosa virulence. Here, we studied the conservation of carP sequence and its occurrence in diverse phylogenetic groups of bacteria. In silico analysis revealed that carP and its two paralogues PA2017 and PA0319 are primarily present in P. aeruginosa and belong to the core genome of the species. We identified 155 single nucleotide alterations within carP, 42 of which lead to missense mutations with only three that affected the predicted 3D structure of the protein. PCR analyses with carP-specific primers detected P. aeruginosa specifically in 70 clinical and environmental samples. Sequence comparison demonstrated that carP is overall highly conserved in P. aeruginosa isolated from diverse environments. Such evolutionary preservation of carP illustrates its importance for P. aeruginosa adaptations to diverse environments and demonstrates its potential as a biomarker.

show abstract

“…P. aeruginosa however, is one of the leading causes of pneumonia in HIV patients (103)(104)(105)(106) and a common respiratory pathogen in patients with AIDS, where pulmonary and respiratory disease infections are often chronic and intractable (107)(108)(109)(110)(111).…”

Section: P Aeruginosa In Immunocompromised Patientsmentioning

confidence: 99%

Characterization of the poxAB Operon Encoding a Class D Carbapenemase in Pseudomonas aeruginosa,

Zincke¹

View full text Add to dashboard Cite

HIV-related bronchopulmonary infection by pseudomonas aeruginosa in the HAART era: radiological findings

Abstract: Cavitation was more frequent in patients that were not receiving HAART, and normal chest radiographs were more frequently seen in patients on HAART.

Cited by 8 publications

References 21 publications

Genomic and metabolic versatility of Pseudomonas aeruginosa contributes to its inter-kingdom transmission and survival

Genomic and metabolic versatility of Pseudomonas aeruginosa contributes to its inter-kingdom transmission and survival

carP, encoding a Ca2+-regulated putative phytase, is evolutionarily conserved in Pseudomonas aeruginosa and has potential as a biomarker

Characterization of the poxAB Operon Encoding a Class D Carbapenemase in Pseudomonas aeruginosa,

Contact Info

Product

Resources

About