HIV seropositivity in adolescents with syphilis

McCabe, Edward R.B.; Jaffe, Leslie R.; Díaz, Ángela

doi:10.1016/0197-0070(91)90465-x

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“…In the 1980s, studies showed that 70% of serum specimens from homosexual men with AIDS reacted in treponemal tests for syphilis (168). More recent studies in the heterosexual popu-lation indicate that approximately 60% of HIV-infected females had reactive syphilis serologic test results (15) and that 15% of the adolescents that were reactive in the tests for syphilis also tested positive for HIV antibodies (128). Although most HIV-infected persons who also are infected with T. pallidum appear to respond normally in the serologic tests for syphilis and have typical clinical signs (63,169), several exceptions have been published (38,108,162) or reported to the CDC.…”

Section: Figmentioning

confidence: 99%

Laboratory diagnosis and interpretation of tests for syphilis

1995

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The lack of a method for demonstrating the presence of Treponema pallidum by growth necessitates the use of alternative methods. Traditionally, these methods are divided into direct detection methods (animal inoculation, dark-field microscopy, etc.) and serologic tests for the presence of patient antibody against T. pallidum. Serologic methods are further divided into two classes. One class, the nontreponemal tests, detects antibodies to lipoidal antigens present in either the host or T. pallidum; examples are the Venereal Disease Research Laboratory and rapid plasma reagin and tests. Reactivity in these tests generally indicates host tissue damage that may not be specific for syphilis. Because these tests are easy and inexpensive to perform, they are commonly used for screening, and with proper clinical signs they are suggestive of syphilis. The other class of test, the treponemal tests, uses specific treponemal antigens. Confirmation of infection requires a reactive treponemal test. Examples of the treponemal tests are the microhemagglutination assay for antibodies to T. pallidum and the fluorescent treponemal antibody absorption test. These tests are more expensive and complicated to perform than the nontreponemal tests. On the horizon are a number of direct antigen, enzyme-linked immunosorbent assay, and PCR techniques. Several of these techniques have shown promise in clinical trials for the diagnosis of congenital syphilis and neurosyphilis that are presently difficult to diagnose.

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Section: Figmentioning

confidence: 99%

Laboratory diagnosis and interpretation of tests for syphilis

1995

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“…[101][102][103][104][105][106][107][108] Com relação à sífilis, estudos mostraram altas prevalências de infecção pelo T pallidum em homossexuais e mulheres heterossexuais infectados pelo HIV, 109,110 e que adolescentes infectados pelo T. pallidum tinham alta prevalência de infecção pelo HIV. 111 Como a maioria dos casos de infecção pelo virus da hepatite C são de transmissão parenteral o exame foi realizado para mensurar (e validar) a história de uso de drogas injetáveis ou exposição parenteral, enquanto que o exame para detecção de infecção pelo Treponema pallidum visava mensurar a exposição sexual. Os resultados inconclusivos e fraco reatores foram repetidos.…”

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Aids e tuberculose na casa de detenção de São Paulo

Rozman¹

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HIV seropositivity in adolescents with syphilis

Cited by 2 publications

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Laboratory diagnosis and interpretation of tests for syphilis

Laboratory diagnosis and interpretation of tests for syphilis

Aids e tuberculose na casa de detenção de São Paulo

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