HIV-specific CTL in infected children

Buseyne, Florence; Fleury, Béatrice; Burgard, Marianne; Teglas, Jean Paul; Bui, Elise; Mayaux, Marie Jeanne; Rouzioux, Christine; Blanche, Stéphane; Rivière, Yves

doi:10.1016/s0165-2478(97)85094-8

Immunology Letters

1997

DOI: 10.1016/s0165-2478(97)85094-8

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HIV-specific CTL in infected children

Florence Buseyne

Béatrice Fleury

Marianne Burgard

et al.

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“…In HIV-1-infected patients, antiviral CTL arise early in infection (9)(10)(11) and are present within uncultured circulating peripheral blood mononuclear cells (PBMC) as a subset of CD8 ϩ cells (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). The rate of CTL-mediated killing should influence both the half-life of virus-infected cells and the amount of virus production.…”

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confidence: 99%

“…Results derived from published studies of fresh responses by many other workers (12)(13)(14)(15)(16)(17)(18) can also be used to calculate target cell half-lives (Fig. 2D).…”

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confidence: 99%

“…Targets were chromium-labeled, washed, and plated at 5000 cells per well as described in A. (D) Half-lives of target cells derived from published studies of lysis by fresh PBMC from HIV-1-infected patients (12)(13)(14)(15)(16)(17)(18). Points represent individual patients.…”

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confidence: 99%

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Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection

Klenerman

Phillips

Rinaldo

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

106

100

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To understand the role of the immune system in limiting HIV type 1 replication, it is critical to know to what extent the rapid turnover of productively infected cells is caused by viral cytopathicity or by immune-mediated lysis. We show that uncultured peripheral blood mononuclear cells of many patients contain cytotoxic T lymphocytes (CTL) that lyse target cells-at plausible peripheral blood mononuclear cell-to-target ratios-with half-lives of less than 1 day. In 23 patients with CD4 counts ranging from 10 to 900 per l, the average rate of CTL-mediated lysis corresponds to a target cell half-life of 0.7 day. We develop mathematical models to calculate the turnover rate of infected cells subjected to immune-mediated lysis and viral cytopathicity and to estimate the fraction of cells that are killed by CTL as opposed to virus. The models provide new interpretations of drug treatment dynamics and explain why the observed rate of virus decline is roughly constant for different patients. We conclude that in HIV type 1 infection, CTL-mediated lysis can reduce virus load by limiting virus production, with small effects on the half-life of infected cells.

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mentioning

confidence: 99%

“…Results derived from published studies of fresh responses by many other workers (12)(13)(14)(15)(16)(17)(18) can also be used to calculate target cell half-lives (Fig. 2D).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection

Klenerman

Phillips

Rinaldo

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

106

100

View full text Add to dashboard Cite

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HIV-specific CTL in infected children

Cited by 1 publication

References 0 publications

Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection

Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection

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