HL-A Antigens in Graves’ Disease and Hashimoto’s Thyroiditis

Farid, Nadir R.; Barnard, John M.; Kutas, Cecilia; Noel, Elke P.; Marshall, William H.

doi:10.1159/000231467

Cited by 32 publications

(9 citation statements)

References 4 publications

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“…Previous studies from various laboratories (Bode et al 1973, Farid et al 1975, van Rood et al 1975, Mayr et al 1976, Konishi e t al. 1977, Moens & Farid 1978, including three of our own (Farid et al 1975, Farid et al 1976, Moens & Farid 1978, failed to show significant association between autoimmune thyroiditis and HLA. Whereas some studies recorded an incidence of HLA-B8 similar to control values, others showed that B8 (or Bw35 in the Japanese) results in a relative risk in the region of 1.60 (Farid et al 1975, Konishi e t al.…”

Section: Discussionmentioning

confidence: 96%

“…Observations in laboratory animals have suggested that both experimental and spontaneous thyroiditis could be related to histocompatibility genes of the respective species (Vladutiu & Rose 1971, Bacon et al (1974) Bigazzi & Rose 1975. It therefore came as a surprise when no significant association was observed between the human disease, Hashimoto's thyroiditis (Bode et al 1973, Farid et al 1975, van Rood et al 1975, Mayr et al 1976, Konishi et al 1977, Moens & Farid 1978 and specific HLA-A and -B antigens, in contrast to the reported association between Graves' disease and products of the major Histocompatibility complex (Grumet et al 1974, Thorsby et al 1975, Farid et al 1979). These differences in associations were all the more puzzling because of the clinical observations that the twu diseases may occur within the same family group (Farid et al 1977) or indeed coincide in the same patient.…”

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confidence: 99%

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The Association of HLA‐B8 with Atrophic Thyroiditis

et al. 1979

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One‐hundred‐and‐forty‐seven patients with autoimmune thyroiditis were studied with respect to HLA antigens as they related to various clinical features. HLA‐B8 was found to be significantly increased among 59 patients with atrophic thyroiditis (57% vs. 26% for controls) but was identical to controls in 88 patients with goitrous thyroiditis (26%). No relation was found in either group between B8 and thyroid autoantibody titer or, in the case of goitrous thyroiditis, the rate of progression of the disease. Thus a link seems to be established between Graves' disease and atrophic thyroiditis in that both are significantly associated with HLA‐B8. This study stresses the need to take clinical features into consideration when examining for HLA/disease associations.

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Section: Discussionmentioning

confidence: 96%

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confidence: 99%

The Association of HLA‐B8 with Atrophic Thyroiditis

et al. 1979

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“…Both chronic lymphocytic thyroiditis and mitral valve prolapse can be familial in type [10,11] and in both there are findings point ing to an autoimmune etiology [12,13]. For mitral valve prolapse Schlant et al [ 12] have reported that 20 of 40 patients with this con dition had a positive antinuclear factor com pared with only 4% in a matched control group.…”

Section: Commentmentioning

confidence: 99%

Prevalence of Mitral Valve Prolapse in Chronic Lymphocytic Thyroiditis and Nongoitrous Hypothyroidism

Brauman¹,

Rosenberg²,

Gilboa³

et al. 1988

Cardiology

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An increased prevalence of mitral valve prolapse has been found in Graves’ disease and a common autoimmune etiology has been suggested for both disorders. We investigated the prevalence of mitral valve prolapse in 87 patients with autoimmune chronic lymphocytic thyroiditis, 50 patients with nongoitrous hypothyroidism and 111 healthy control subjects. Mitral valve prolapse was found in 16.09% of patients with chronic lymphocytic thyroiditis compared to 6 and 5.4% in nongoitrous hypothyroidism and normal controls, respectively. The result is statistically significant, p < 0.02, and confirms that the prevalence of mitral valve prolapse is significantly increased in patients with autoimmune disorders of the thyroid gland, when compared to normals and nonautoimmune conditions.

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“…An association between HLA-B8 and Graves' disease has been described from studies of several Caucasian populations (Farid et al 1975, Grumet et al 1975, Tborsby et al 1975, Whittingham et al 1975). An even greater association was recorded between Graves' disease and HLA-Dw3 (Thorsby et al 1975, Bech et al 1976).…”

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confidence: 91%

The HLA Bw4/w6 Diallelic System in Graves' Disease

et al. 1978

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We studied the diallelic system HLA--Bw4/w6 in patients with Graves' disease and control subjects. Twenty-one out of the 22 patients with Graves' disease were found to be HLA--Bw6 positive and 16 of these were homozygous, contrasted with 28 and 9 out of 34 controls, respectively. HLA--Bw6 positivity results in a relative risk for Graves' disease of 3.27; homozygosity for that allele further increases the risk to 7.4. It is possible that the increased risk attached to HLA--Bw6 is secondary to the increase in HLA--B8 previously described in Graves' disease.

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HL-A Antigens in Graves’ Disease and Hashimoto’s Thyroiditis

Cited by 32 publications

References 4 publications

The Association of HLA‐B8 with Atrophic Thyroiditis

The Association of HLA‐B8 with Atrophic Thyroiditis

Prevalence of Mitral Valve Prolapse in Chronic Lymphocytic Thyroiditis and Nongoitrous Hypothyroidism

The HLA Bw4/w6 Diallelic System in Graves' Disease

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