HLA-A*01:01 in MHC is associated with psoriatic arthritis in Chinese Han population

Chen, Jingjing; Yang, Fan; Zhang, Yan; Fan, Xing; Xi, Hui; Qian, Wenjun; Chang, Yu‐Ling; Zuo, Xianbo; Zheng, Xiaodong; Liang, Bo; Zhang, Yuanjing; Sun, Liangdan; Yang, Sen; Zhang, Xuejun

doi:10.1007/s00403-019-01902-3

Cited by 10 publications

(15 citation statements)

References 22 publications

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“…In our study population, we found the HLA class II alleles, DRB1*04:04 and DRB1*04:05, which have been described as associated with susceptibility to rheumatoid arthritis [38][39][40], while the DRB1*03:01 allele with Systemic Lupus Erythematosus [41,42]. Another allele associated with autoimmune diseases is HLA-A*01:01, which has been associated with the development of psoriatic arthritis in the Chinese population [43]. In a pilot study in the Mexican population, HLA-DQB1*05 was associated with susceptibility of reinfection with human papillomavirus [44].…”

Section: Discussionmentioning

confidence: 54%

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

et al. 2020

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Genetic variability defends us against pathogen-driven antigens; human leucocyte antigens (HLA) is the immunological system in charge of this work. The Mexican mestizo population arises mainly from the mixture of three founder populations; Amerindian, Spaniards, and a smaller proportion of the African population. We describe allele and haplotype frequencies of HLA class I (-A and -B) and class II (-DRB1 and -DQB1), which were analyzed by PCR-SSP in Mexican mestizo from three urban populations of Mexico: Chihuahua-Chihuahua City (n = 88), Mexico City-Tlalpan (n = 330), and Veracruz-Xalapa (n = 84). The variability of the allele HLA class I and class II among the three regions of Mexico are in four alleles: HLA-A*24:02 (36.39%), -B*35:01 (16.04%), -DRB1*04:07 (17.33%), and -DQB1*03:02 (31.47%), these alleles have been previously described in some indigenous populations. We identified 5 haplotypes with a frequency >1%: HLA-A*02:01-B*35:01-DRB1*08:02-DQB1*04:02, A*68:01-B*39:01-DRB1*08:02-DQB1*04:02, A*02:01-B*35:01-DRB1*04:07-DQB1*03:02, A*68:01-B*39:01-DRB1*04:07-DQB1*03:02, and A*01:01-B*08:01-DRB1*03:01-DQB1*02:01. Also, the haplotype A*02:01-B*35:01-DRB1*08:02-DQB1*04:02 was identified in Tlalpan and Xalapa regions. Haplotype A*01:01-B*08:01-DRB1*03:01-DQB1*02:01 was found only in Tlalpan and Chihuahua. In the Xalapa region, the most frequent haplotype was A*24:02-B*35:01-DRB1*04:07-DQB1*03:02. These alleles and haplotypes have been described in Amerindian populations. Our data are consistent with previous studies and contribute to the analysis of the variability in the Mexican population.

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Section: Discussionmentioning

confidence: 54%

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

et al. 2020

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“…Psoriasis patients with HLA-B*27 and/or -Cw*12 may have a higher risk of developing PsA [ 52 ]. Chen et al [ 53 •] found that HLA-A*01:01 and HLA-A*01 may be susceptibility genes associated with PsA and confirmed the association of four loci with PsA in a Chinese Han population. From population-based surveys in China, the prevalence of PsA in China appeared to be similar to that in the rest of the world, ranging from 10 to 100 per 100,000 population [ 30 ].…”

Section: Psoriatic Arthritismentioning

confidence: 88%

Spectrum of Spondyloarthritis Among Chinese Populations

Zhang

Zhao³

et al. 2022

Curr Rheumatol Rep

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Purpose of Review This review aims to emphasize interesting and important new findings with a focus on the spectrum of spondyloarthritis (SpA) in China. Recent Findings Over the past decade, significant advances have been made in the investigation of SpA epidemiology, the exploration of genetic and environmental risk factors, the identification of clinical features, and the updating of treatment protocols in the Chinese population. The prevalence of ankylosing spondylitis (AS) in China is 0.20–0.42%, and the prevalence of HLA-B27 in AS patients is 88.8–89.4%. HLA-B*2704 is the most common subtype in Chinese AS patients, followed by HLA-B*2705. HLA-A*01, more precisely HLA-A*01:01, may be associated with psoriatic arthritis (PsA). Tumor necrosis factor inhibitors and IL-17A inhibitors have been shown to be effective and safe for AS patients in China. Juvenile-onset AS is relatively rare, accounting for only 9.1% of the AS population. The prevalence of arthritis related to inflammatory bowel disease is 6.9 to 7.2%. A Chinese study showed that the most frequently prescribed medication was methotrexate (66.4%). Biological agents were prescribed in only16.4% of patients with PsA. Summary This review summarizes the latest research in the epidemiology, pathogenesis, clinical manifestations, and management of SpA among Chinese populations. Multiple HLA associations with SpA have also been described, and it is hoped that discoveries of such ethnic-specific risk factor(s) and understanding of their pathological mechanisms may potentially lead to newer targeted therapies for the Chinese populations worldwide.

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“…12 HLA-A*01:01 may act as a risk factor, participating in the pathological process of PsA in a Chinese Han population. 13 are negatively associated with PsA in a White population. 14 As well as the HLA genes, the susceptibility non-HLA genes are also shown as important in the pathogenesis of PsA.…”

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confidence: 86%

“…For instances, HLA‐B*38 and HLA‐Cw6 alleles are protective alleles against PsA, and HLA‐A*11 and HLA‐B*7 are susceptibility‐associated alleles for PsA in an Argentine population 12 . HLA‐A*01:01 may act as a risk factor, participating in the pathological process of PsA in a Chinese Han population 13 . HLA‐B*38 , HLA‐B*13 , HLA‐B*37 , HLA‐B*27 , HLA‐B*17 and HLA‐Bw*16 are positively associated with PsA, while HLA‐B*12 and HLA‐Bw*35 are negatively associated with PsA in a White population 14 .…”

Section: Introductionmentioning

confidence: 99%

Psoriatic arthritis: A systematic review of non‐HLA genetic studies and important signaling pathways

et al. 2020

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Psoriatic arthritis (PsA) is a chronic inflammatory disease that primarily invades the musculoskeletal system and skin. 1 Usually, besides the arthritis damage, including arthritis, enthesitis, dactylitis and axial involvement, patients with PsA have psoriatic skin, such as epidermal hyperplasia, hyperkeratosis, parakeratosis, Munro's microabscesses and mixed dermal infiltrates. 2 In general, the severity of a patient's joint symptoms is consistent with the severity of the skin lesions. 3 In some cases, patients with PsA without psoriatic skin features only have arthritis damage or finger pain, which is similar to rheumatoid arthritis (RA). Generally, only about 13% of patients with PsA have rheumatoid factor in the blood and synovial fluid, while more than 80% of RA patients can be detected with rheumatoid factor. 4 The prevalence of PsA around the world is 0.3%-1%, 4 which differs in race and regions. In Western countries, the prevalence rates are about 0.02%, 0.42% and 0.25% in Sweden, Italy and the USA respectively, 5,6 whereas the rates are relatively lower in the Eastern countries, ranging from 0.01% to 0.1% in China, and <0.00001% in Japan. 6 PsA is not only harmful to an individual's health and life quality, but also may lead to a higher risk to suffer from cardiovascular events. 7 The pathogenesis of PsA is complex, and itmay be caused by genetic and environmental factors. Environmental aspects include infections (eg infectious diarrhea, human immunodeficiency virus infection), smoking, trauma and obesity. 8-11 In the researches for susceptibility genes for PsA, some human leukocyte antigen (HLA) genes are found as risk factors, and some HLA genes are found as protect factors. For instances, HLA-B*38 and HLA-Cw6 alleles are

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HLA-A*01:01 in MHC is associated with psoriatic arthritis in Chinese Han population

Cited by 10 publications

References 22 publications

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

HLA Allele and Haplotype Frequencies in Three Urban Mexican Populations: Genetic Diversity for the Approach of Genomic Medicine

Spectrum of Spondyloarthritis Among Chinese Populations

Psoriatic arthritis: A systematic review of non‐HLA genetic studies and important signaling pathways

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