HLA‐A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP)

Abstract

Based on modern DNA techniques the present study shows an association of HLA to both RPP and AP. Certain HLA alleles seem to be associated with susceptibility or resistance to periodontitis in general. However, before this knowledge can be used for differential diagnosis or prognosis, further investigations are necessary.

Periodontal disease in pediatric rheumatic diseases

“…40 In fact, the increased serum levels of IL-18 and IL-1 in JIA patients accompanied by a similar subgingival microbiota suggest that the increased frequency of incipient attachment loss observed in these patients might be due to their altered systemic inflammatory response, making them more susceptible to PD. 33 Additionally, for periodontitis, 41 as well as for JIA, 42 associations to HLA classes I and II alleles were reported, and HLA-DRB3 could be a common putative risk for JIA and chronic periodontitis among females. 43 In fact, the immune response to bacteria is influenced by human leucocyte anti- 44,45 and individual peptide binding capability of cell surface HLA receptors.…”

Human leukocyte antigen polymorphism in chronic and aggressive periodontitis among Caucasians: a meta‐analysis

“…Variety of associations Differentiation of the results of Machulla et al (2002) as to gender differences in HLA association (original data published in Machulla et al 2002 AP (50) CP (102) No period.…”

“…Variety of associations Differentiation of the results of Machulla et al (2002) as to HLA allele combinations (original data published in Machulla et al 2002) AdultP, adult periodontitis; CP, chronic periodontitis; AP, aggressive periodontitis; JP, juvenile periodontitis, LJP, localized juvenile periodontitis; RPP, rapidly progressive periodontitis, ProfP, profound periodontitis; BD, blood doners; popul., population; no period., no periodontitis; HLA, human leukocyte antigens. (102) A11 ", A29 ", DRB1 n 13 ", A31 #, A30/31 #, DRBbl #…”

“…Calculations resulted in significantly positive associations of HLA-A9 and -B15 with increased OR, whereas HLA-A2 and -B5 had significantly negative associations with lower frequencies of these markers among the patients (Table 6). Only two studies (Shapira et al 1994, Machulla et al 2002) examined HLA-B15 split antigens, but none of the splits showed a predominant association. There are not enough data to demonstrate whether the associations of HLA-A9, -B15 and -B5 were caused by the association of only one or both their split antigens (HLA-A23, -A24 for HLA-A9; HLA-B62, -B63, -B75, -B76, -B77 for HLA-B15; and HLA-B51, -B52 for HLA-B5).…”

Associations of HLA-A, -B and -DRB1 Types with Oral Diseases in Swiss Adults

“…Previously, associations have been documented between HLA antigens and periodontitis [8] [9] [10] [11]. A meta-analysis reported HLA class I types HLA-A9 and -B15 to indicate susceptibility to aggressive periodontitis, whereas HLA-A2 and -B5 were potential protective factors against aggressive periodontitis [12].…”