HLA‐A, HLA‐B, and HLA‐DRB1 Allele and Haplotype Frequencies in Renal Transplant Candidates in a Population in Southern Brazil

Saito, Patrícia Keiko; Yamakawa, Roger Haruki; Noguti, Érika Noda; Bedendo, Gustavo Borelli; Júnior, Waldir Veríssimo da Silva; Yamada, Sérgio; Borelli, Sueli Donizete

doi:10.1002/jcla.21846

Cited by 6 publications

(6 citation statements)

References 40 publications

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“…Полученные нами данные созвучны с результатами исследования, проведенными в Бразилии, где среди пациентов с ХБП также наиболее часто выявлялся HLA-А02 (25,4%) (у нас данный АГ выявлялся наиболее часто) и другие антигены -HLA-В44 (10,9%) и HLA-DR13 (13,9%) [45]. В другом исследовании из этой же страны у кандидатов на трансплантацию почки наиболее часто выявлялись HLA-А02, HLA-B35 и HLA-DR11, что также созвучно с нашими результатами (у нас данные АГ выявлялись в 53,7%, 19,75% и 16,05% случаев соответственно) [44].…”

Section: Discussionunclassified

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

Korzhenevsky

Korzhenevskaya

2022

Med. immunol.

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The aim of our study was to specify the features of the HLA system in patients registered on the waiting list for kidney transplantation in the Republic of Bashkortostan. HLA-A, HLA-B, and HLA-DR phenotypes were assayed by polymerase chain reaction using PROTRANS and OLERUP SSP kits. The frequency of antigen occurence was determined as the percentage of individuals with the given antigen to the total number of examined individuals. To determine the patterns of distinct antigens within various HLA combinations, we determined maximal percentage of the antigen frequency in combination with other HLA. The largest number of patients on the waiting list suffered from chronic glomerulonephritis, followed by diabetes mellitus, chronic interstitial nephritis, chronic pyelonephritis and polycystic kidney disease. The occurrence frequency of various HLA and their combinations was established both among all the patients suffering from stage 5 chronic kidney disease, and among patients with regard to each nosological category, and the patterns of various HLA combinations were established. The data obtained have been compared with the study results of patients from the waiting lists for organ transplantation in other regions. HLA-A02 (similar to Brazil, Great Britain), HLA-DR07, HLA-DR04 (like as in Nepal, European population of Kazakhstan, Southern China), HLA-A24 (as in Nepal, Southern China), and combinations of HLA-A02-A03, HLA-A02-DR04, HLA-A02-DR01, HLA-A02-B07, HLA-A03-DR01, HLA-B35-DR01 were most common in the patients with chronic kidney disease which can be considered as risk factor for severe nephropathy. HLA-B15, HLA-B40, HLA-vA30, HLA-A32, HLA-B56, HLA-B60, HLA-DR10 were found at minimal frequency; as well as the following combinations: HLA-A01-A24-B08-DR17, HLA-A01-A68-DR07, HLAA24-B07-B13, HLA-A01-B08-B13, HLA-A02-B35-B38-DR01, HLA-A02-B50-B61-DR07, HLA-A01-B55-DR04, HLA-A02-B55-DR03, HLA-A24-B55-DR13, HLA-A01-A02-B08-DR03, HLA-A02-DR01-DR13. The following antigens were absent among our patients: HLA-A28 (similar to Kuwait); HLA-A11, HLA-A23, HLA-A28, HLA-A33, HLA-B46, HLA-B62;-DR03, HLA-DR14 (as in Kazakhstan); HLAA19, HLA-A43, HLA-B16, HLA-B21, HLA-B22, HLA-B83 and HLA-DR05 (as in Great Britain); HLAB14 (as in Brazil). The results obtained were either similar, or different from the literature data, both in terms of the most common HLA and their combinations with regard of special nephropathy types. The revealed differences can be explained by presence of population-specifical HLA features in the patients from different ethnic groups and living in different geographical areas. The found stable associative links between the disorders and HLA may contribute to better understanding of pathogenesis of the disorders, their early preclinical detection, evaluating risk for development of pathological conditions, thus allowing timely justification of preventive measures.

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Section: Discussionunclassified

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

Korzhenevsky

Korzhenevskaya

2022

Med. immunol.

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“…The most common allelic groups for each locus were HLA‐A*02 (25.4%), HLA‐B*44 (10.9%), and HLA‐DRB1*13 (13.9%), and the most common haplotypes were HLA‐A*01 ~ B*08 ~ DRB1*03 (2.3%), A*02~B*44~DRB1*07 (1.2%), and A*03 ~ B*07 ~DRB1*11 (1.0%). Significant differences in allele frequencies were observed among population groups based on skin color for the following allelic groups HLA‐A*68 , ‐B*08 , and ‐B*58 . Similarly, Ravazzi‐Gauch et al described the frequencies for 2624 renal transplant patients, all from São Paulo state.…”

Section: Transplant and Disease Association Studiesmentioning

confidence: 98%

“…In this study, associations were found between the allelic groups HLA-A*78 and HLA-DRB1*11 with end-stage renal disease 53 (Table 2). Saito et al 60 described the allelic and haplotypic frequency in 512 patients (319 White, 134 Brown, and 69 Black), also in chronic renal failure candidates for renal transplantation, all from the Northern and Northwest regions of Paraná state. The most common allelic groups for each locus were HLA-A*02 (25.4%), HLA-B*44 (10.9%), and HLA-DRB1*13 (13.9%), and the most common haplotypes were HLA-A*01~B*08~DRB1*03 (2.3%), A*02~B*44D RB1*07 (1.2%), and A*03~B*07~DRB1*11 (1.0%).…”

Section: Transplant and Disease Association Studiesmentioning

confidence: 99%

“…Significant differences in allele frequencies were observed among population groups based on skin color for the following allelic groups HLA-A*68, -B*08, and -B*58. 60 Similarly, Ravazzi-Gauch et al 61 described the frequencies for 2624 renal transplant patients, all from São Paulo state. In this group of patients, the most frequent alleles were HLA-A*02, HLA-B*35, and HLA-DRB1*11, whereas the haplotype HLA-A*01~B*08~DRB1*03 was the most frequent in the White group and HLA-A*29~B*44~DRB1*07 in the Black group.…”

Section: Transplant and Disease Association Studiesmentioning

confidence: 99%

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HLA diversity in Brazil

Boquett

Bisso‐Machado

Zagonel-Oliveira

et al. 2019

HLA

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Brazil is the fifth largest country in the world in area and the fifth most populous. The Brazilian voluntary Bone Marrow Donor Registry is the third largest in terms of number of donors in the world, being a valuable source of HLA genetics to characterize the donor population of Brazil as well. The genetic background of the Brazilian population is quite heterogeneous, resulting from 5 centuries of admixture among Native Americans, Europeans and Africans, making the Brazilian population unique in terms of genetic ancestry. The unique characteristics of populations in different Brazilian regions make them an exciting focus for genetic diversity studies. Studies on HLA genetic diversity of Brazilian populations have been conducted since the late 1980s and, in this review, we highlight the main findings from studies carried out in Brazil based on classical HLA. In addition, we calculated the genetic distance from the molecular data of the studies included in this review in order to have a broader view of the HLA diversity in Brazilian populations. We emphasize that characterization of HLA diversity is not only important for transplantation programs, but can shed a light on ancestry, history and other demographic patterns with or without association with autoimmune disease.

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“…A DRC apresenta altas taxas de incidência e prevalência e tem se configurado como um problema de saúde mundial, com elevados custos para a saúde pública, sendo o transplante renal considerado uma das melhores opções de terapia e reabilitação de pacientes com doença renal em estágio terminal (14,15,16).…”

Section: Introductionunclassified

Avaliação Da Frequência Alélica E Haplotípica Do Sistema Hla Para Os Loci Hla-A, Hla-B E Hla-Drb1 De Receptores Renais E Doadores Intervivo Do Estado Do Pará, Brasil/ Evaluation of the Allelic and Haplotypic Frequency of the Hla System for Hla-A, Hla-B E Hla-Drb1 Loci of Renal Receptors and Living Donors From the State of Pará, Brazil

Barros

Mattos

Cabral

et al. 2021

BJD

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Introdução: A descoberta dos antígenos leucocitários humano (HLA) trouxe o reconhecimento de que a compatibilidade do sistema HLA entre doador e receptor é um fator importante em transplantes de órgãos, tecidos e células. No transplante renal, a compatibilidade desse sistema está associada a sobrevida do enxerto em longo prazo e a incompatibilidade está envolvida diretamente na reatividade imunológica do receptor

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HLA‐A, HLA‐B, and HLA‐DRB1 Allele and Haplotype Frequencies in Renal Transplant Candidates in a Population in Southern Brazil

Abstract: This study provides the first data on the HLA-A, HLA-B, and HLA-DRB1 allele, phenotype and haplotype frequencies of renal transplant candidates in a population in southern Brazil.

Cited by 6 publications

References 40 publications

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

HLA system features in patients on waiting list for kidney transplantation in the Republic of Bashkortostan

HLA diversity in Brazil

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