HLA-A, HLA-B and HLA-DRB1 haplotype frequencies in Piauí’s volunteer bone marrow donors enrolled at the Brazilian registry

Carvalho, Marayza Gomes; Tsuneto, Luiza Tamie; Neto, José Machado Moita; Sousa, Luiz Claudio D.M.; Filho, Herton Luiz Alves Sales; Macêdo, Marina Barguil; Barroso, José Renato; Pereira, Ester Miranda; Araújo, A. S.; Silva, A.S.; Monte, Semíramis Jamil Hadad do

doi:10.1016/j.humimm.2013.08.283

Cited by 13 publications

(19 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HLA‐A*02 and A*03 variants were more frequent in all groups, but no significant differences were observed between groups. In this study, the distribution of these alleles was similar to the results of other population studies carried out in Brazil, such as in Parana (Ruiz et al ., ; Bardi et al ., ), Sao Paulo (Salvadori et al ., ) and populations from north‐east of Brazil (Nigam et al ., ; Carvalho et al ., ). When compared with REDOME (), these allele variants had a similar distribution for each region, with a little difference in the frequencies presented in this study.…”

Section: Discussionmentioning

confidence: 97%

“…In relation to B locus , HLA‐B*15 , B*35 and B*51 were most frequent and common in all three groups, similar to the results of other studies with populations from north/north‐west regions of Parana State (Ruiz et al ., ), north‐east of Sao Paulo State (Castelli et al ., ), Pernambuco State (Nigam et al ., ) and Piaui State (Carvalho et al ., ). HLA‐B*57 showed a significant difference among groups 1 and 3, being more frequent in the Afro‐Brazilian group (4.2%).…”

Section: Discussionmentioning

confidence: 97%

“…Brazil is a continental country that has specific regional characteristics and is populated by the descendants of immigrants from many countries (Carvalho et al, 2013). The genetic constitution of the Brazilian population presents peculiarities that vary by region, and the investigation of such alleles and haplotypes of HLA system provides insight on the study of genetic composition and the origin of different populations (Bortolotto et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Allele and haplotype frequencies of HLA‐A, B, C, DRB1 and DQB1 genes in polytransfused patients in ethnically diverse populations from Brazil

Rodrigues

Macedo

Bruder

et al. 2015

Int J Immunogenetics

View full text Add to dashboard Cite

The red blood transfusion is a practice often used in patients with haematological and oncological diseases. However, the investigation of human leucocyte antigen (HLA) system frequency in these individuals is of great importance because multiple transfusions may lead to HLA alloimmunization. Brazil is a country that was colonized by many other ethnicities, leading to a mixed ethnicity and regionalized population. In view of the importance of HLA typing in these patients, the aim of this study was to investigate the allele and haplotype frequencies from polytransfused patients from three different regions from Brazil. HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 genotyping of 366 patients was performed by PCR-SSO, based on the Luminex technology (One Lambda(®) ), and the anti-HLA class I and class II antibodies were analysed using LabScreen Single Antigen Antibody Detection (One Lambda, Inc.). Allele and haplotype frequencies of polytransfused patients of three regions from Brazil were obtained using the Arlequin program. The most frequent allele frequencies observed were HLA-A*02, A*03, B*15, B*35, B*51, C*07, C*04, C*03, DRB1*13, DRB1*11, DRB1*07, DRB1*03, DRB1*01, DQB1*03, DQB1*02, DQB1*06 and DQB1*05. There were differences between the groups for allele variants HLA-B*57 (between Group 1 and Group 2) and HLA-C*12 (between Group 1 and Group 3). The most frequent haplotypes found in the sample were HLA-A*01B*08DRB1*03, DRBI*07DQB1*02, DRB1*01DQB1*05, DRB1*13DQB1*06 and A*02B*35. HLA class I and II antibodies were detected in 77.9% and 63.9% patients, respectively, while the both alloantibodies were detected in 62 (50.9%) patients. In conclusion, the HLA typing for polytransfused patients in each region has a great importance, as seen in this study; individuals from different regions from Brazil have HLA distribution not completely homogeneous.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Allele and haplotype frequencies of HLA‐A, B, C, DRB1 and DQB1 genes in polytransfused patients in ethnically diverse populations from Brazil

Rodrigues

Macedo

Bruder

et al. 2015

Int J Immunogenetics

View full text Add to dashboard Cite

show abstract

“…A study carried out with class I HLA in 101 admixed individuals (20% characterized as White and 80% as non-White) from the state of Pernambuco presented results consistent with the anthropological evidence of the origin of the population of this state. 45 Similarly, Carvalho et al, 46 when analyzing lowresolution HLA-A, -B and -DRB1 data from almost 22 000 voluntary bone marrow donors (REDOME) in Piauí also found data that coincide with the history of the settlement of the state. In this study, alleles and haplotypes with Native American origin were found in low frequency, being the population studied composed of a pool of alleles of Caucasian, Hispanic and African origin.…”

Section: Bone Marrow Donors and Other Studies In Urban Populationsmentioning

confidence: 84%

HLA diversity in Brazil

Boquett

Bisso‐Machado

Zagonel-Oliveira

et al. 2019

HLA

View full text Add to dashboard Cite

Brazil is the fifth largest country in the world in area and the fifth most populous. The Brazilian voluntary Bone Marrow Donor Registry is the third largest in terms of number of donors in the world, being a valuable source of HLA genetics to characterize the donor population of Brazil as well. The genetic background of the Brazilian population is quite heterogeneous, resulting from 5 centuries of admixture among Native Americans, Europeans and Africans, making the Brazilian population unique in terms of genetic ancestry. The unique characteristics of populations in different Brazilian regions make them an exciting focus for genetic diversity studies. Studies on HLA genetic diversity of Brazilian populations have been conducted since the late 1980s and, in this review, we highlight the main findings from studies carried out in Brazil based on classical HLA. In addition, we calculated the genetic distance from the molecular data of the studies included in this review in order to have a broader view of the HLA diversity in Brazilian populations. We emphasize that characterization of HLA diversity is not only important for transplantation programs, but can shed a light on ancestry, history and other demographic patterns with or without association with autoimmune disease.

show abstract

“…The number of papers that show the HLA profiles of different populations and ethnic groups, as well as papers that combine and summarize these results (Nunes et al, ; Nunes, Buhler, Roessli, & Sanchez‐Mazas, ), is constantly rising. Donor registries are used as biggest source for subjects in population studies in the recent years (Carvalho et al, ; Schmidt et al, ; Wu et al, ). The information about HLA alleles and haplotypes, as well as rare alleles, are important in the process of stem cell transplantation from unrelated donors (Balas, García‐Sánchez, & Vicario, ).…”

Section: Introductionmentioning

confidence: 99%

HLA profile of the donors in the Macedonian Bone Marrow Donor Registry

Kirijas

Stavrik

Trajkov

et al. 2018

Int J Immunogenetics

View full text Add to dashboard Cite

The importance of HLA alleles in the process of haematopoietic stem cell transplantation, especially the process of unrelated donor search, is enormous. Macedonian Bone Marrow Donor Registry was established in 2010 and has registered volunteer donors from different nationalities that live in the Republic of Macedonia. The aim of this study was to determine the HLA allele and haplotype frequencies of the volunteer donors from the Macedonian Bone Marrow Donor Registry and to compare this results with the Macedonians from a family study. We analyzed 1,541 donors, with different nationalities, Macedonian, Albanian and Macedonian Muslims that were most numerous in MBMDR, and typed them for HLA-A, -B, -C, -DRB1, whereas Macedonian also for HLA-DQA1 and HLA-DQB1 by SSO method (One Lambda, CA, USA). The most frequent alleles in Macedonians were HLA-A*02, 01, 24; HLA-B*35, 18, 51; HLA-C*07, 04, 12; HLA-DRB1*11, 16, 13; HLA-DQA1*01, 05 and HLA-DQB1*05, 03, 06; in Albanians they were HLA-A*02, 24,01; HLA-B*51, 18, 35; HLA-C*07, 04, 12, HLA-DRB1*11, 13,16; and in Macedonian Muslims they were HLA-A*02, 01, 24; HLA-B*18, 51, 35, HLA-C*07, 04, 02 and HLA-DRB1*11, 16, 14. The most common haplotype in Macedonian was HLA-A*01-B*08-C*07-DRB1*03, whilst in Albanian and Macedonian Muslims HLA-A*02-B*18-C*07-DRB1*11. The comparison of the HLA allele groups between Macedonian from MBMDR and family study showed similar distribution. This study confirmed the close relationship between the populations that live in the Balkan Peninsula.

show abstract

HLA-A, HLA-B and HLA-DRB1 haplotype frequencies in Piauí’s volunteer bone marrow donors enrolled at the Brazilian registry

Cited by 13 publications

References 19 publications

Allele and haplotype frequencies of HLA‐A, B, C, DRB1 and DQB1 genes in polytransfused patients in ethnically diverse populations from Brazil

Allele and haplotype frequencies of HLA‐A, B, C, DRB1 and DQB1 genes in polytransfused patients in ethnically diverse populations from Brazil

HLA diversity in Brazil

HLA profile of the donors in the Macedonian Bone Marrow Donor Registry

Contact Info

Product

Resources

About