HLA‐A2 class I antigens in couples with recurrent spontaneous abortions

Abstract

Class I human leukocyte antigen (HLA) antigens, locus A and B, were typed in fertile and infertile couples in cases where one of the spouses carried the HLA-A2 antigen. HLA-class I typing data were obtained from 282 participants, 63 fertile couples and 78 infertile couples with recurrent spontaneous abortions (RSA). Locus A antigens were grouped into eight broad specificities (A1, A2, A3, A9, A10, A11, A19, A28) and locus B antigens were grouped, according to HLA epitopes, in two classes (BW4 and BW6). Although the number of cases is small, significant differences in the distribution of locus A antigens were found between HLA-A2-positive (A2+) women from fertile and infertile couples. HLA-A3, A11 and A28 cross-reacting antigens were absent in women from fertile couples and present in women from infertile couples. HLA-A19, which is associated with amino acid triplets of low immunogenicity, was significantly more often observed in A2+ fertile than in infertile women. An excess of the BW4 epitope was found in A2(-) husbands from infertile couples compared to fertile ones. The results of this study support the idea that in the presence of the HLA-A2 molecule the distribution of HLA-A and B loci antigens may be different in fertile couples compared to couples with recurrent spontaneous abortions. It can be suggested that the HLA-A2 molecule, in context with specific genotypes, may contribute to the overall maternal immune response in normal and disturbed pregnancy.

Biochemical Characterization of Transporter Associated with Antigen Processing (TAP)-Like (ABCB9) Expressed in Insect Cells

“…However, our system did not demonstrate a positive or negative effect with peptides such as HLA-B27, HLA-A2, ICP47, amyloid-b and a-mating factor. 21,[26][27][28] Nevertheless, our system will be helpful for further biochemical analysis of TAPL since at least nucleotide binding capability is preserved.…”

Genome-Wide Screening for Risk Loci of Idiopathic Recurrent Miscarriage in a Han Chinese Population: A Pilot Study

“…6,10,11 It is known that IRM is a multifactorial disorder, both genetic and environmental factors contributing to its etiology. 1,9 Polymorphisms and mutations that appear to affect the susceptibility of IRM have been identified in FV, 12 Apo E, 13 HLA, [14][15][16] p53, 8 and VEGF genes. 17,18 However, none of these genes above, once thought to be responsible for IRM, has been confirmed.…”

Associação de alelos HLA e aborto espontâneo recorrente em uma população de São Luís/Maranhão, na região Nordeste do Brasil

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