HLA-A29.2 Subtype Associated With Birdshot Retinochoroidopathy

Lehoang, P.; Özdemır, Nezıh; Benhamou, A.; Tabary, Thierry; Edelson, C.; Bétuel, H; Semiglia, Renato; Cohen, J

doi:10.1016/s0002-9394(14)75749-6

Cited by 94 publications

(54 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The association rate was estimated to be approximately 95 % in different subsequent reports [32,33]. LeHoang et al found that BRC was associated with the HLA-A29-2 subtype [34], which was later put in doubt [35]. It becomes increasingly likely that the association is closer to 100 %, as false negatives are not so rare when the antibody testing method is used.…”

Section: Hla Testingmentioning

confidence: 99%

New concepts in the appraisal and management of birdshot retinochoroiditis, a global perspective

Papadia¹,

Herbort

2015

Int Ophthalmol

View full text Add to dashboard Cite

Birdshot retinochoroiditis (BRC) is a relatively recently described entity. BRC uveitis is predominant in the posterior segment with dual, independent retinal, and choroidal inflammation. The disease has no known extra-ocular inflammation sites and yet features the strongest known HLA association: HLA-A29 is present in close to 100 % of cases. Aim in this mini-review was to readjust the appraisal of BRC in the light of a global approach including the full array of investigational procedures. Historical background and the genesis of the disease name were searched. Global disease description including both the retina and the choroid was given. Retinal involvement was clearly characterized, pointing toward the profuse leakage of retinal vessels of all sizes in early disease and widespread atrophy in under treated patients. The importance of exploration of choroidal disease, unavailable until the early 1990s before the advent of indocyanine green angiography (ICGA) was stressed, allowing early diagnosis of disease. Despite its proven importance to explore the choroid, ICGA is still sparsely used. Existing diagnostic criteria were found to be clearly inappropriate not allowing early diagnosis and are in need to be revised, taking into account both retinal and choroidal aspects of the disease, in order to make early diagnosis possible and hence allow proper management .

show abstract

Section: Hla Testingmentioning

confidence: 99%

New concepts in the appraisal and management of birdshot retinochoroiditis, a global perspective

Papadia¹,

Herbort

2015

Int Ophthalmol

View full text Add to dashboard Cite

show abstract

“…The disease is also accompanied by retinal vasculitis and vitritis, but minimal anterior segment inflammation. There is a strong association of this disease with the HLA-A29 haplotype [2, 5,7]. Patients often present with complaints of blurry vision, floaters, photopsias, and difficulty with night vision [2].…”

Section: Introductionmentioning

confidence: 99%

Electroretinograms as an indicator of disease activity in birdshot retinochoroidopathy

Zacks

Samson

Loewenstein

et al. 2002

Graefe's Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

show abstract

“…12 It remains unclear why BCR is such a rare form of uveitis, as control population carrier rates of HLA-A29 are approximately 7%. [13][14][15] The allele frequency of HLA-A*2901 is 0.0019 in whites and 0.0010 in African Americans. The allele frequency of HLA-A*2902 is 0.0434 in whites and 0.0357 in African Americans.…”

Section: Discussionmentioning

confidence: 99%

Hla-A29–positive Birdshot Chorioretinopathy in an African American Patient

Knezevic

Munk

Pappas

et al. 2016

RETINAL Cases &Amp; Brief Reports

View full text Add to dashboard Cite

Birdshot chorioretinopathy overwhelmingly affects non-Hispanic Caucasians, but there have been rare reported cases in other ethnicities including Hispanics and African Americans. This patient's ethnicity may have contributed to the 10-year delay in diagnosis. To our knowledge, this is the first documented HLA-A29 positive case of birdshot chorioretinopathy in an African American. HLA-A29 may be a useful supportive test in cases with classic clinical presentation in non-Caucasian patients to enable the correct diagnose in a timely manner.

show abstract

HLA-A29.2 Subtype Associated With Birdshot Retinochoroidopathy

Cited by 94 publications

References 7 publications

New concepts in the appraisal and management of birdshot retinochoroiditis, a global perspective

New concepts in the appraisal and management of birdshot retinochoroiditis, a global perspective

Electroretinograms as an indicator of disease activity in birdshot retinochoroidopathy

Hla-A29–positive Birdshot Chorioretinopathy in an African American Patient

Contact Info

Product

Resources

About