HLA analysis of Sri Lankan Sinhalese predicts North Indian origin

Malavige, Gathsaurie Neelika; Rostron, Tim; Seneviratne, SL; Fernando, S.S.N.; Sivayogan, S; Wijewickrama, Ananda; Ogg, Graham S.

doi:10.1111/j.1744-313x.2007.00698.x

Cited by 18 publications

(20 citation statements)

References 15 publications

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“…The origin of the Sinhalese population of Sri Lanka is disputed. However, studies based on human leukocyte antigen (HLA) have shown that Sinhalese are more likely to originate from the Aryans than the Dravidians [30]. Sinhalese are genetically closer to Caucasoid populations than to other neighboring Mongoloid populations [31].…”

Section: Discussionmentioning

confidence: 99%

Sexual dimorphism in digital dermatoglyphic traits among Sinhalese people in Sri Lanka

Wijerathne

Rathnayake²,

Adikari³

et al. 2013

J Physiol Anthropol

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BackgroundThe purpose of this study was to evaluate gender-wise diversity of digital dermatoglyphic traits in a sample of Sinhalese people in Sri Lanka.FindingsFour thousand and thirty-four digital prints of 434 Sinhalese individuals (217 males and 217 females) were examined for their digital dermatoglyphic pattern distribution. The mean age for the entire group was 23.66 years (standard deviation = 4.93 years). The loop pattern is observed more frequently (n = 2,592, 59.72%) compared to whorl (n = 1,542, 35.53%) and arch (n = 206, 4.75%) in the Sinhalese population. Females (n = 1,274, 58.71%) have a more ulnar loop pattern than males (n = 1,231, 56.73%). The plain whorl pattern is observed more frequently in males (n = 560, 25.81%) compared to females (n = 514, 23.69%).The double loop pattern is observed more frequently on the right and left thumb (digit 1) of both males and females. Pattern intensity index, Dankmeijer index and Furuhata index are higher in males.ConclusionsUlnar loop is the most frequently occurring digital dermatoglyphic pattern among the Sinhalese. All pattern indices are higher in males. To some extent, dermatoglyphic patterns of Sinhalese are similar to North Indians and other Caucasoid populations. Further studies with larger sample sizes are recommended to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Sexual dimorphism in digital dermatoglyphic traits among Sinhalese people in Sri Lanka

Wijerathne

Rathnayake²,

Adikari³

et al. 2013

J Physiol Anthropol

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“…HLA types of the normal population was derived from a study previously done by us [17]. As only 102 individuals (who were recruited from the Colombo district) were included in our previous study, we recruited 17 more healthy individuals who so far never had a symptomatic/clinically diagnosed dengue infection from the Colombo district.…”

Section: Methodsmentioning

confidence: 99%

HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population

et al. 2011

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BackgroundHLA class I and class II alleles have been shown to be associated with the development of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) in different populations. However, the majority of studies have been based on limited numbers of patients. In this study we aimed to investigate the HLA-class I and class II alleles that are positively and negatively associated with the development of DSS in a cohort of patients with DHF and also the alleles associated with development of DHF during primary dengue infections in a Sri Lankan population.Methodology/Principal FindingsThe allele frequencies of HLA class I and class II alleles were compared in 110 patients with DHF and 119 individuals from the population who had never reported a symptomatic dengue infection at the time of recruitment. We found that HLA-A*31 (corrected P = 0.01) and DRB1*08 (corrected P = 0.009) were associated with susceptibility to DSS when infected with the dengue virus, during secondary dengue infection. The frequency of DRB1*08 allele was 28.7 times higher than in the normal population in patients with DSS. HLA-A*31 allele was increased 16.6 fold in DHF who developed shock when compared to those who did not develop shock. A*24 (corrected P = 0.03) and DRB1*12 (corrected P = 0.041) were strongly associated with the development of DHF during primary dengue infection.Conclusions/SignificanceThese data suggest that certain HLA alleles confer susceptibility/protection to severe dengue infections. As T cell epitope recognition depend on the HLA type of an individual, it would be now important to investigate how epitope specific T cells associate with primary and secondary dengue infections and in severe dengue infections.

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“…It is to be noted that allele group of *03 is highly frequent among target population followed by DQB1*06, -*05 and -*02 alleles with 0.2440, 0.1780 and 0.1330 values respectively, and subsequently absence of allele group *04 in present study and is very rare among other Indian populations (Agrawal et al 2008;Kohaar et al 2009;Seshasubramanian et al 2018) with lowest frequency as well (Table1). Rarity of DQB1*04 allele is visible in other South and West Asian populations (Malavige et al 2007;Mohyuddin et al 2002;Farjadian et al 2004) and also in some Southeast Asian (Hoa et al 2008;Sanchez-Mazas 2006;Zhao et al 1993) countries than other world populations. One interpretation for discrepancy in allele combinations of HLA genes between different populations is the complementary and compensatory abilities of allelic products encoded by the haplotype to bind peptide epitopes from different pathogens, another being past population differentiations or recent admixture of populations (Sanchez-Mazas et al 2011).…”

Section: Resultsmentioning

confidence: 94%

Genetic affinity of Muslim population in South India based on HLA-DQB1 and relationship with other Indian Populations

Mohsenpour¹,

Chandrasekar²

2019

Int.J.Mod.Anthrop

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The present study made an attempt to observe genetic affinity of the Muslim population in South India with other neighbor populations. In this regard, DQB1 loci of HLA class II gene as a common genetic marker in phylogenetic assessment has been examined in 45 unrelated healthy individuals using sequence-based typing. The result of this study indicates a close genetic similarity among Indian sub-populations, in spite of segregation with other Muslim populations in North India. Although results of present study indicates genetic relationship of selected populations, all HLA loci or at least all loci of each classes to be assessed in order to attain highly probability of estimates.

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HLA analysis of Sri Lankan Sinhalese predicts North Indian origin

Cited by 18 publications

References 15 publications

Sexual dimorphism in digital dermatoglyphic traits among Sinhalese people in Sri Lanka

Sexual dimorphism in digital dermatoglyphic traits among Sinhalese people in Sri Lanka

HLA Class I and Class II Associations in Dengue Viral Infections in a Sri Lankan Population

Genetic affinity of Muslim population in South India based on HLA-DQB1 and relationship with other Indian Populations

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