HLA Antigen Distribution and HLA Haplotype Segregation in Crohn's Disease

Peña, Amado Salvador; Biemond, I.; Kuiper, George G. J. M.; Weterman, Irene T.; Leeuwen, A. van; Schreuder, Ieke; Rood, Jon J. van

doi:10.1111/j.1399-0039.1980.tb00287.x

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Cited by 33 publications

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“…The various distributions of HLA‐A and HLA‐B antigens sometimes demonstrated in patients with IBD have not always been confirmed (1,2,32‐34). In contrast to the strong association of HLA‐B8 with celiac disease, attempts to link Crohn's disease and ulcerative colitis to a specific HLA‐A or B antigen have failed (1,2).…”

Section: Discussionmentioning

confidence: 99%

Crohn's Disease and Ulcerative Colitis with Onset in the Same Year in Two Sisters

Castro,

Rosati,

Lucidi

et al. 1996

J. pediatr. gastroenterol. nutr.

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Section: Discussionmentioning

confidence: 99%

Crohn's Disease and Ulcerative Colitis with Onset in the Same Year in Two Sisters

Castro,

Rosati,

Lucidi

et al. 1996

J. pediatr. gastroenterol. nutr.

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The `Idiopathic' Inflammatory Bowel Diseases

Kirsner¹

1982

Arch Dermatol

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Linkage analyses of chromosome 6 loci, including HLA, in familial aggregations of Crohn disease

et al. 1994

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Segregation analyses of familial aggregations of Crohn disease have provided consistent results pointing to the involvement of a predisposing gene with a recessive mode of inheritance. Although extensively investigated, the role played by human leucocyte antigen (HLA) genes in this inflammatory bowel disease remains elusive and the major histocompatibility complex is a candidate region for the mapping of the Crohn disease susceptibility gene. A total of 25 families with multiple cases of Crohn disease was genotyped for HLA DRB1 and for 16 highly polymorphic loci evenly distributed on chromosome 6. The data were subjected to linkage analysis using the lod score method. Neither individual nor combined lod scores for any family and for any locus tested reached values suggesting linkage or genetic heterogeneity. The Crohn disease predisposing locus was excluded from the whole chromosome 6 with lod scores less than -2. It was excluded from the major histocompatibility complex and from 91% of the chromosome 6 genetic map with lod scores less than -4. The major recessive gene involved in genetic predisposition to Crohn disease does not reside on the major histocompatibility complex nor on any locus mapping to chromosome 6.

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HLA Antigen Distribution and HLA Haplotype Segregation in Crohn's Disease

Cited by 33 publications

References 9 publications

Crohn's Disease and Ulcerative Colitis with Onset in the Same Year in Two Sisters

Crohn's Disease and Ulcerative Colitis with Onset in the Same Year in Two Sisters

The `Idiopathic' Inflammatory Bowel Diseases

Linkage analyses of chromosome 6 loci, including HLA, in familial aggregations of Crohn disease

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