HLA antigens and congenital dislocation of the hip

Zervas, J.; Zoubopoulos, H; Constantopoulos, C; S, Theodorou; Toubis, M.; Fessas, Phaedon

doi:10.1111/j.1399-0039.1983.tb01206.x

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…In Greek children with DDH [270] there was a significant increase in HLA A 1 in the DDH group (52 versus 26%). In Czechoslovakia, there was a significant decrease in the HLA B 7 type in the DDH group (10% versus 26%) [271].…”

Section: Resultsmentioning

confidence: 99%

“…This region contains a cluster of HOX genes that provide specific positional identities to mesenchymal cells in developing joints [277]. In French Caucasians, there was no increased association between DDH and the HOXB9 gene [270] while in the Chinese there is an association with the HOXB9 as well as the COL1A1 genes in DDH [278]. In Italian Caucasians, the COLL2A1 and vitamin D receptor genes are associated with nonsyndromic DDH [279] but not confirmed by others [280].…”

Section: Resultsmentioning

confidence: 99%

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The Epidemiology and Demographics of Hip Dysplasia

2011

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The etiology of developmental dysplasia of the hip (DDH) is unknown. There are many insights, however, from epidemiologic/demographic information. A systematic medical literature review regarding DDH was performed. There is a predominance of left-sided (64.0%) and unilateral disease (63.4%). The incidence per 1000 live births ranges from 0.06 in Africans in Africa to 76.1 in Native Americans. There is significant variability in incidence within each racial group by geographic location. The incidence of clinical neonatal hip instability at birth ranges from 0.4 in Africans to 61.7 in Polish Caucasians. Predictors of DDH are breech presentation, positive family history, and gender (female). Children born premature, with low birth weights, or to multifetal pregnancies are somewhat protected from DDH. Certain HLA A, B, and D types demonstrate an increase in DDH. Chromosome 17q21 is strongly associated with DDH. Ligamentous laxity and abnormalities in collagen metabolism, estrogen metabolism, and pregnancy-associated pelvic instability are well-described associations with DDH. Many studies demonstrate an increase of DDH in the winter, both in the northern and southern hemispheres. Swaddling is strongly associated with DDH. Amniocentesis, premature labor, and massive radiation exposure may increase the risk of DDH. Associated conditions are congenital muscular torticollis and congenital foot deformities. The opposite hip is frequently abnormal when using rigorous radiographic assessments. The role of acetabular dysplasia and adult hip osteoarthritis is complex. Archeological studies demonstrate that the epidemiology of DDH may be changing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Epidemiology and Demographics of Hip Dysplasia

2011

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“…DDH can be observed as an isolated anomaly or as part of a Mendelian or chromosomal syndrome [21]. The etiology of nonsyndromic DDH is not known, but wide evidence of familial aggregation [19,20], high concordance between monozygotic twins (41%) compared with dizygotic twins (2.8%), and high risk of recurrence (5%) for subsequently born siblings [19] strongly suggest a crucial role for genetic factors.…”

Section: Introductionmentioning

confidence: 99%

Exclusion of COL2A1 and VDR as Developmental Dysplasia of the Hip Genes

Rubini

Cavallaro

Calzolari

et al. 2008

Clinical Orthopaedics &Amp; Related Research

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Developmental dysplasia of the hip (DDH) is a spectrum of disorders affecting the proximal femur and/or acetabulum leading to an abnormal formation of the hip. Genetic factors are involved in the etiology of DDH. Early recognition of DDH affords the best results from treatment and a better knowledge of the genetics of DDH could enhance early diagnosis. Variants in the Type II collagen (COL2A1) and vitamin D receptor (VDR) genes have been associated with patients with osteoarthritis of the hip secondary to DDH, suggesting these genes could contribute to DDH. To see whether there was linkage between the COL2A1/VDR locus and nonsyndromic DDH, we conducted a linkage study on 11 families with multiple cases of DDH. We demonstrated no evidence of linkage between the COL2A1/VDR locus and nonsyndromic DDH (LOD score \ -2), suggesting, although variants in these genes could play a role in osteoarthritis in patients with DDH, they do not contribute to nonsyndromic DDH. The search for causal gene variants should proceed with other candidates.

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Association of hla–dr and hla–dq antigens with congenital dislocation and dysplastic osteoarthritis of the hip joints in japanese people

Torisu¹,

Fujikawa²,

Yano³

et al. 1993

Arthritis & Rheumatism

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Objective. To investigate the frequency of HLA-DR and DQ antigens among patients with congenital dislocation of the hip joint or dysplastic osteoarthritis (OA) and to determine whether tissue typing might contribute to better understanding of these disorders.Methods. HLA-DR and DQ typing was undertaken in 18 patients with congenital dislocation of the hip joints, 65 patients with dysplastic OA of the hip, 42 patients with primary OA of the knee!, and 40 normal controls. Typing for HLA-D antigens was performed using the standard microlymphocytotoxicity method.Results. The frequency of HLA-DR4 in patients with congenital dislocation of the hip joint (61.1%) and patients with dysplastic OA of the hip (58.5%) was significantly increased compared with normal controls (27.5%) (P,,,, < 0.05 and P < 0.01, respectively). The relative risk for HLA-DR4 was 4.1428 and 3.7104, respectively, in these 2 disease groups. The frequency of HLA-DR4 in the patients with primary OA of the knee (35.7%) did not differ significantly from that in normal controls.Conclusion. The results strongly indicate that development of congenital dislocation of the hip joint and progression of dysplastic OA of the hip are associated with genes of the HLA-D region.

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HLA antigens and congenital dislocation of the hip

Cited by 6 publications

References 3 publications

The Epidemiology and Demographics of Hip Dysplasia

The Epidemiology and Demographics of Hip Dysplasia

Exclusion of COL2A1 and VDR as Developmental Dysplasia of the Hip Genes

Association of hla–dr and hla–dq antigens with congenital dislocation and dysplastic osteoarthritis of the hip joints in japanese people

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