HLA Antigens and Peptic Ulcer Disease

Kang, Jin Young; Doran, T; Crampton, Roslyn; McClenehan, Wendy; Piper, D. W.

doi:10.1159/000198874

Cited by 11 publications

(1 citation statement)

References 4 publications

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“…Family and epidemiological studies also support the role of genetic factors in the aetiology of peptic ulcer [38–40]. Some genetic markers such as blood group O, non‐secretor status, hyperpepsinogenaemia and HLA antigens have been described as beind associated with peptic ulcer, although results have been conflicting so far [41–46].…”

Section: Discussionmentioning

confidence: 99%

The polymorphic IL-1B and IL-1RN genes in the aetiopathogenesis of peptic ulcer

Garcı́a-González

Lanas

Santolaria

et al. 2001

Clinical and Experimental Immunology

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SUMMARYBesides environmental factors, the genetic background of an individual may contribute to the development and final outcome of peptic ulcer disease. Interleukin-1b (IL-1b ) and the interleukin-1 receptor antagonist (IL-1ra) are cytokines that play a key role in modulating the inflammatory response in the gastrointestinal mucosa. This study aimed to investigate whether polymorphisms in the IL-1B and IL-RN genes are involved in the susceptibility to and final outcome of peptic ulcer disease. DNA from 179 unrelated Spanish Caucasian patients with peptic ulcer diseases and 99 ethnically matched healthy controls was typed for the TaqI polymorphism at position 1 3954 in the IL-1B gene and the variable number of tandem repeats polymorphism in intron 2 of the IL-1RN gene. The determination of Helicobacter pylori status and non-steroidal anti-inflammatory drug (NSAIDs) use was studied in all patients and in controls. H. pylori infection and NSAID use were more frequent in ulcer patients than in controls. There were no significant differences in carriage rate, genotype and allele frequencies of the IL-1RN and the IL-1B 13954 gene polymorphisms between peptic ulcer patients and controls. However, a strong allelic association between IL-1B and IL-1RN genes was found in duodenal ulcer patients (P , 0´0006). Logistic regression identified H. pylori infection and NSAIDs use as independent risk factors for peptic ulcer diseases whereas the simultaneous carriage of IL-1B 13954 allele 2 and IL-1RN allele 2 was associated with reduced risk for duodenal ulcer disease (OR: 0´37, 95% CI 0´14±0´9). Our data suggest that IL-1B and IL-1RN genes in addition to bacterial and environmental factors play a key role in determining the final outcome of peptic ulcer disease.

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Section: Discussionmentioning

confidence: 99%