HLA Antigens, Blood Groups and Serum Protein Groups in Patients with Intermittent Claudication

Abstract

HLA (A and B) antigens, blood group systems (ABO, Rh, MNSs, P, Kell, Lewis and Duffy) and serum group systems (Hp, Tf, Pi, C3 and C4) were studied in patients with intermittent claudication (IC) and controls. HLA antigen A 28 was significantly more common, and blood group 0 was significantly less common among the patients than among the controls. A comparison between patients with IC and those with abdominal aortic aneurysms showed a significant difference between these two groups concerning the MN blood groups.

ABO(H) blood groups and vascular disease: a systematic review and meta‐analysis

“…For PVD, we observed a pooled OR of 1.45 (95% CI 1.35–1.56) for non‐O relative to O. Interestingly, whilst only some used objective diagnosis [35,36,39,40], or comparable controls [21,35,38], the findings were highly consistent. For CIAO, pooling of the small number of available studies revealed that blood group non‐O produces a small, but significant, increased risk of CIAO (OR 1.14, 95% CI 1.01–1.27).…”

“…The key limitations to MI/angina studies were not reporting result uncertainty (12 studies) [17–28] and a lack of control for potential population stratification (12 studies) [17,22–24,26–33]. For PVD, no study reported result uncertainty and/or provided detailed demographic data [21,34–40]. Studies on CIAO were generally of good quality, although four did not define CIAO using modern imaging [21,41–43].…”

“…Eight studies reported an increased risk of PVD with non‐O (Fig. 1), with 4 employing an objective diagnosis [35,36,39,40] and three [21,35,38] using similar controls (Table S3). The pooled OR for the risk of PVD for non‐O relative to O was 1.45 (95% CI 1.35–1.56).…”