HLA antigens in Japanese patients with central nervous system lupus

Kawai, Takako; Katoh, Kiyoshi; Tani, Kenji; Okuda, Kenji; Okubo, Tadanobu

doi:10.1111/j.1399-0039.1990.tb01754.x

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…30 Numerous candidate gene loci, especially the alleles from the HLA region, have been implicated through case-control association studies. [31][32][33][34][35][36][37][38][39][40][41] HLA-G plays a vital role in immune modulation. It is involved in the modulation of the cytotoxicity of NK cells and T-cells, inhibiting T-cell proliferation and dendritic cell maturation, and promoting an immune deviation from Th1 to Th2 response.…”

Section: Discussionmentioning

confidence: 99%

Lack of association between HLA-G 14-bp polymorphism and systemic lupus erythematosus in a Han Chinese population

et al. 2009

Lupus

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HLA-G is a non-classical HLA-class Ib molecule with multiple immunoregulatory properties. A 14-bp insertion/deletion polymorphism in the HLA-G gene has been suggested to influence the expression of HLA-G and to associate with certain pathological conditions, including autoimmune diseases. We investigated the influence of the 14-bp insertion/deletion polymorphism in the HLA-G gene on disease susceptibility in systemic lupus erythematosus by genotyping this polymorphism in 231 patients with systemic lupus erythematosus and 367 healthy controls and analyzing the levels of soluble HLA-G in a subset of patients with systemic lupus erythematosus and healthy subjects from a Han Chinese population. No statistically significant differences were observed in the frequencies of the 14-bp insertion/deletion HLA-G alleles or genotypes between controls and patients with systemic lupus erythematosus. However, a significant increased expression of soluble HLA-G was noted in patients with systemic lupus erythematosus (mean value = 230.2 U/ml vs 118.3 U/ml in controls, p = 0.0001). Moreover, patients with high levels of soluble HLA-G presented with higher disease activity and had more neurological involvement. Our results do not support the HLA-G 14-bp insertion/deletion polymorphism as a genetic factor influencing systemic lupus erythematosus susceptibility. It is possible that the expression of soluble HLA-G in systemic lupus erythematosus is enhanced as part of a mechanism to try to restore the tolerance process towards auto-antigens and to counteract inflammation. However, the participation of this molecule in the pathological process of the disease also could not be excluded.

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Section: Discussionmentioning

confidence: 99%

Lack of association between HLA-G 14-bp polymorphism and systemic lupus erythematosus in a Han Chinese population

et al. 2009

Lupus

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“…Since then, HLA studies have been performed on multiple SLE populations of African, Asian, European, and North, Central and South American descent demonstrating different HLA associations among the various ethnic groups. [39][40][41][42][43][44][45][46][47][48][49][50][51] From these studies, HLA-DR2 and -DR3 appear to have the strongest associations with SLE. (HLA-B8 was most consistently associated with SLE, but was later found to be in linkage disequilibrium with -DQ2 and -DR3.)…”

Section: Hla Antigensmentioning

confidence: 99%

The genetics of systemic lupus erythematosus: putting the pieces together

2002

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“…Eine Häufigkeit von 25 -50% darf als realistisch gelten [165 (Übersicht)). In der bisher einzigen Uapanischen) Studie zur genetischen Prädisposition wurde eine Assoziation mit HlA-Bw61 gefunden [86).…”

Section: Klinische Manifestationenunclassified

Neuropsychiatrischer systemischer Lupus erythematodes

Harten¹

1996

Akt Rheumatol

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HLA antigens in Japanese patients with central nervous system lupus

Cited by 6 publications

References 3 publications

Lack of association between HLA-G 14-bp polymorphism and systemic lupus erythematosus in a Han Chinese population

Lack of association between HLA-G 14-bp polymorphism and systemic lupus erythematosus in a Han Chinese population

The genetics of systemic lupus erythematosus: putting the pieces together

Neuropsychiatrischer systemischer Lupus erythematodes

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