HLA Antigens in Patients with Psoriasis

Abstract

Tissue typing was performed on lymphocytes of 46 Jewish patients with psoriasis vulgaris. HLA B13, B17, B37 and Cw6 were found increased. It is suggested that the increase in the B and C locus antigens is inter-related and may determine the genetic predisposition for the development of this disease.

Immunogenetic Analysis of Association between HLA Antigens and Psoriasis vulgaris: Population and Family Studies

“…Whilst some studies in the USA [14,17] indicated an increased frequency of HLA-Bwl6, the increase found in our ethnic group was equivocal because it did not result significant after correction, as suggested by Svejgaard et al [22] in a large study of European Caucasoids. Present findings also confirmed a striking association of psoriasis and Cw6, demonstrated by other authors [8,17,25], This was due to the high linkage disequilibrium ofCw6 with B13, B17 and B37 [3a], indicating that association of B locus antigens with psoriasis are secondary to the association of Cw6 with the disease.…”

“…The increase in the frequency of B13 and B17 antigens shown in an Italian population (Apulia Region) of psoriatic patients agreed with the findings in other populations [8,11,20,22,28], confirming a wide asso ciation between HLA antigens and psoriasis.The question of disturbed frequency of other HLA antigens was more uncertain. Whilst some studies in the USA [14,17] indicated an increased frequency of HLA-Bwl6, the increase found in our ethnic group was equivocal because it did not result significant after correction, as suggested by Svejgaard et al [22] in a large study of European Caucasoids.…”

“…The association between psoriasis and the HLA antigens B13, Bwl6, B17, B37 has been found by several authors [1,8, 11, 12, 15, 2 la, 22, 26-28, 30], while other studies [8,17,24,25] have indicated that this association to these B deter minants might be secondary to Cw6 a factor which occurs in approxi mately 50% of psoriasis patients [16]. Other authors [9,17] have shown that two HLA-D alleles (provisionally called El and DMA), which are closely associated with B13 and B17, are increased in psoriatic patients, 1 1 Cw6 = allele o f a third (HLA-C) locus, mapped between HLA-A and HLA-B loci on human chromosome 6.…”

“…Bl 7 or Cw6, indicated that the Is gene could also segregate with an other haplotype. The Is gene is also dominant, with an incomplete penetrance of B17 and Bw35 among relatives.Genetic factors are disputed in the etiology of psoriasis and the exact mode of inheritance has not been identified [8,13]. The association between psoriasis and the HLA antigens B13, Bwl6, B17, B37 has been found by several authors [1,8, 11, 12, 15, 2 la, 22, 26-28, 30], while other studies [8,17,24,25] have indicated that this association to these B deter minants might be secondary to Cw6 a factor which occurs in approxi mately 50% of psoriasis patients [16].…”

HLA determinants in psoriasis vulgaris in Israel

“…The association of the disease with Cw6 is more significant in non-Ashkenazi than in Ashkenazi patients (x2 = 11.7 vs x2 = 2.8, respectively), while the frequency of Cw6 among healthy individuals is similar in both subpopulations. In a previous study, Gazit et al (1978) also reported an increase in Cw6 among Jewish psoriatic patients. PSV has also been reported to be associated with DR7 (Marcusson et al 1981, Tiwari et al 1982.…”