HLA Antigens in Peyronie’s Disease

Rompel, Rainer; Mueller‐Eckhardt, G.; Schroeder‐Printzen, I.; Weidner, W.

doi:10.1159/000282566

Cited by 28 publications

(19 citation statements)

References 8 publications

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“…They found a positive correlation only with HLA B27 and concluded that, because none of the bacterial cultures were positive, molecular mimicry or infection was not responsible for PD. 27 Rompel et al 12,13 performed HLA typing on 52 unrelated individuals with PD using a modi®ed lymphotoxicity test for both class I and II MHC. They found a statistically signi®cant association with HLA A1 and HLA DQw2, and in their 1994 study, they reported an association with HLA B8, Cw7 and DR3.…”

Section: Discussionmentioning

confidence: 99%

“…The ®rst two reports that demonstrated a positive association evaluated only 17 patients combined, 30,33 but two other studies, evaluating 80 patients, 10,13 failed to demonstrate a positive association. With respect to class II MHC, only Rompel 13 reported an association. 25 In a study of 31 males, Nachtsheim and Rearden 11 reported an association with HLA DQ5.…”

Section: Discussionmentioning

confidence: 99%

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The genetics and immunology of Peyronie's disease

Noss

Day

et al. 2000

Int J Impot Res

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Peyronie's disease (PD) is a condition characterized by localized and often progressive ®brosis and scarring of the penis. This condition has an unknown etiology although several hypotheses have been proposed. These include traumatic, immunologic and genetic causes. We studied the genetics and immunology of PD using both molecular biologic and molecular genetic techniques.Men (n 283) with PD were identi®ed by retrospective chart review of one physician's of®ce practice. These men were contacted by telephone and asked to submit to an interview and blood test for genetic studies. Simultaneously, tissue and cells collected in the laboratory were examined by Western and Northern blot analysis for examination of protein and RNA for expression of HLA.Of the ®rst 107 men contacted, 24 were available and consented to interview and blood testing. The mean age was 60.3 y with an average duration of PD of 4.9 y. One patient had a family history of PD while no patients had Dupuytren's contracture. Twenty patients were considered to have primary disease while four were secondary. Eleven patients had tissue prepared for Northern blot analysis and nine patients were the subject of Western blot analysis. All tissue, both Peyronie's and control expressed class I MHC while no tissue expressed class II MHC. The expression of mRNA of class I MHC was equal for Peyronie's and control patients while the expression at the protein level was less in the PD patients.We conclude that PD may have multiple etiologic agents. One cannot exclude a class II MHC association but in our population, HLA DQ is not expressed. Class I MHC may be involved as the expression of class I MHC protein is different in Peyronie's patients than in controls. Genetic studies are ongoing.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The genetics and immunology of Peyronie's disease

Noss

Day

et al. 2000

Int J Impot Res

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“…According to Chilton et al [3] and Hinman [15], it has been associated with a generalized fibrotic tendency, so accompanying diseases have been investigated up to now. Recently, Rompel et al [14] studied the involvement of autoimmune factors in Peyronie's disease, and reported an association between class I and II HLA antigens and Peyronie's disease. They also noticed a common haplotype related with these antigens in Peyronie's disease.…”

Section: Discussionmentioning

confidence: 99%

“…This haplotype has been associated with numerous autoimmune disorders and is also increased in insulindependent diabetes. It has therefore been suggested that Peyronie's disease may be due to an autoimmune disorder and may also have an inherited predisposition similar to other autoimmune diseases [13,14]. Nyberg et al [16] reported father-to-son transmission of Peyronie's disease and Dupuytren's contracture in three generations and suggested that this was an autosomal dominant trait.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors concluded that the prevalence of diabetes mellitus tended to be higher in Peyronie's disease patients than in the control population, but the difference was not statistically significant [8]. Other authors attempted to find an immunogenetic basis for Peyronie's disease and revealed the coincidence of autoimmune disorders in Peyronie's disease [13,14].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between Diabetes mellitus, Impotence and Veno-Occlusive Dysfunction in Peyronie’s Disease Patients

et al. 1998

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Peyronie’s disease is an ill-defined condition that often leads to severe penile deformity and sometimes erectile dysfunction. Penile Doppler studies indicate veno-occlusive dysfunction as the principal cause of poor rigidity in Peyronie’s disease patients. Diabetes mellitus is also a known cause of impotence and its prevalence tended to be higher in patients with Peyronie’s disease. We evaluated 143 patients with Peyronie’s disease, also 92 impotent men (37 diabetic, 55 nondiabetic) as control group. Penile vascular studies were performed on each group. Diabetes mellitus was also investigated in patients with Peyronie’s disease. Veno-occlusive dysfunction was found as the main cause of impotence in both groups (81.1% in diabetic, 89% in nondiabetic control group and 88.8% in Peyronie’s disease patients). In our study group the prevalence of diabetes mellitus tended to be higher than in the control population but it did not alter the ratio of veno-occlusive dysfunction and impotence in Peyronie’s disease patients. We believe there is a close relationship between diabetes mellitus and Peyronie’s disease, considering our high incidence. We also conclude that diabetes mellitus is not the main cause of impotence in patients with Peyronie’s disease.

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