HLA Antigens in Subacute Sclerosing Panencephalitis

HLA and C4 in subacute sclerosing panencephalitis

“…Of HLA class I antigens (A, B, C), Kurent et al (1975) reported an increased incidence of HLA-A29 antigen in 36 Caucasians with SSPE. Conversely, several investigators found no association between SSPE and HLA class I antigens in different ethnic populations (Kreth et al 1975, Aysun et al 1983, Cztonkowska 1986. Similarly, we found no significant association between SSPE and HLA class I antigens among 63 Japanese with SSPE in comparison with 100 unrelated healthy Japanese (Table 1).…”

Thirty years of primary immunodeficiencies in Turkey

“…These studies included the search for human leukocyte antigen (HLA) alleles and immune deviations in diseases, particu-larly those potentially involving host defense mechanisms as associated risk factors or underlying immunological mechanisms in patients with: acute rheumatic fever (ARF), myasthenia gravis, subacute sclerosing panencephalitis (SSPE), Behçet disease, idiopathic centrencephalic epilepsy, Hodgkin's disease, and juvenile periodontal disease. [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] We also investigated the role of other immunological mechanisms that may be involved in clinical severity among affected siblings from the same families. In the late 1970s and early 1980s, AT patients constituted the majority of our PID patients, likely because the distinctive features of the disorder attracted the attention of physicians and led to their referral to us, and because most of these patients can live at least a decade without treatment.…”

“…During the 1970s and 1980s, we also focused on immune aberrations in various pediatric disorders, importantly, as immunology has close ties to every pediatric subspecialty. These studies included the search for human leukocyte antigen (HLA) alleles and immune deviations in diseases, particularly those potentially involving host defense mechanisms as associated risk factors or underlying immunological mechanisms in patients with: acute rheumatic fever (ARF), myasthenia gravis, subacute sclerosing panencephalitis (SSPE), Behçet disease, idiopathic centrencephalic epilepsy, Hodgkin's disease, and juvenile periodontal disease 18–33 . We also investigated the role of other immunological mechanisms that may be involved in clinical severity among affected siblings from the same families.…”