HLA antigens in the pathogenesis of Menière's disease

Xenellis, John; Morrison, A. W.; McClowskey, D.; Festenstein, H.

doi:10.1017/s0022215100098698

Cited by 77 publications

(41 citation statements)

References 8 publications

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“…For at least 2 decades, attention has been focused on the role of the immune system in mediating inner ear pathologies [McCabe, 1979]. MD patients present some features of autoimmune disease, such as a positive family history in some disease, a positive response to steroid treatment [Garcia-Purriños et al, 2005] and a hypothetic association with certain HLA loci (Cw7, A1, B8) [Xenellis et al, 1986]. Furthermore, it is now well known that the inner ear does not represent an immuneprivileged site and can even generate a local immune response, which depends on the presence of an intact endolymphatic sac [Couloigner et al, 2004].…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, serum autoantibodies against internal ear antigens as well as circulating immunocomplexes have been reported in MD patients [Hsu et al, 1990;Derebery, 1997;Yoo et al, 2001;Riente et al, 2004]. Furthermore, MD patients show many features of autoimmune disease, such as a positive family in some histories, the association with certain HLA loci (Cw7, A1, B8) as well as good response to steroid therapy [Shea, 1983;Xenellis et al, 1986, Garcia-Purriños et al, 2005.…”

Section: Introductionmentioning

confidence: 99%

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Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Nacci

Dallan²,

Monzani³

et al. 2009

Audiol Neurotol

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Objective/Hypothesis: The aim of this prospective study is to evaluate the possible association between Ménière’s disease (MD) and autoantibodies. Methods: Fifty-five patients with definite MD (51 unilateral and 4 bilateral) were matched with 55 patients with unilateral vestibular paresis without cochlear involvement and 55 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, anti-TSH receptor antibody, antithyroperoxidase antibody, antithyroglobulin antibody and of antibodies to non-organ-specific antigens, namely antinuclear antibodies, antibodies to extractable nuclear antigens and antineutrophilic cytoplasmic antibodies. Results: Thirty-three subjects (60%) of the MD group had 1 or more elevated serum autoantibody levels, both organ and non-organ specific; 16 patients (29.1%) with unilateral vestibular paresis had 1 or more elevated serum autoantibody levels, while 13 healthy subjects (23.6%) had 1 or more elevated serum autoantibody levels. Conclusions: Based on our data we speculate that there is a more than a chance association between MD and ‘autoimmunity’, thus suggesting a hypothetical role of the immune system in MD pathogenesis. In other words, a pathogenetic role of an ‘immune dysregulation’ in MD patients can be hypothesized.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Nacci

Dallan²,

Monzani³

et al. 2009

Audiol Neurotol

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“…Serum antibodies against internal ear antigens [10] and circulating immunocomplexes [11,12] as well as a positive response to steroid treatment [13,14] have been reported. Furthermore, MD patients present some features of immune diseases, such as hereditary predisposition, a positive family history for the disease and hypothetic association with certain human leucocyte antigen loci (Cw7, A1, B8) [15]. The association between thyroid autoimmunity and other autoimmune disorders is well recognized [16,17].…”

Section: Introductionmentioning

confidence: 99%

Possible association between thyroid autoimmunity and Menière's disease

Fattori¹,

Nacci²,

Dardano³

et al. 2008

Clinical and Experimental Immunology

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SummaryVarious aetiopathological mechanisms have been postulated to be at the root of Menière's disease (MD), and some data suggest that there may be also an underlying autoimmune factor. In fact, Menière patients manifest certain characteristics that are typical of autoimmune involvement association of particular human leucocyte antigen haplotypes, the presence of antibodies against internal ear antigens. In this study, we evaluated the association between thyroid autoimmunity and MD in a non-selected group of patients. We recruited 50 consecutive MD patients and two groups as controls: group A, 82 healthy volunteers; and group B, 50 subjects suffering from acute unilateral peripheral vestibulopathy. All subjects were submitted to instrumental assessment of cochlear-vestibular function and analysis of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-TSH receptor antibody (TR-Ab), anti-thyroperoxidase antibody (TPO-Ab) and antithyroglobulin antibody (Tg-Ab) in the blood. The prevalence of autoimmune thyroiditis in group B [6/50 (12%); 66·7% TPO-Ab and 33·3% Tg-Ab] was superimposable with the healthy controls [6/82 (7%); 66·7% TPO-Ab and 33·3% Tg-Ab]. In contrast, 38% of the MD patients (P = 0·0001 versus group A and group B) had significant autoantibody levels (68·4% TPO-Ab; 15·8% TPO-Ab + TR-Ab; 10·5% Tg-Ab; 5·2% TPO-Ab + Tg-Ab). Furthermore, 14% of the MD patients were hyperthyroid under l-thyroxine therapy, while no dysfunction was seen in the control groups. Overall, our data demonstrate a significant association between MD and thyroid autoimmunity, which suggests that an autoimmune factor is involved in the aetiopathogenesis of this disease. These findings suggest that it should be useful to submit MD patients to multi-disciplinary clinical investigation.

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“…6 Autoimmunity appears to be associated with the pathogenesis of MD. 7 Early studies had found an association between MD and HLA antigensFthe Cw7 antigen in British patients 5 and with the allele DRB1*1602 in a Japanese population 8 Fbut these results were not consistent. Later studies have not confirmed these associations between HLA antigens and sporadic MD.…”

Section: Introductionmentioning

confidence: 97%

“…4 A group of British patients with FMD have shown an autosomal dominant inheritance with 60% penetrance, anticipation and an association with the class I HLA Cw7 antigen. 5 Linkage analysis has pointed to chromosome 14, but sequencing has excluded any mutation of the 12 coding exons of COCH gene in the British families. 6 Autoimmunity appears to be associated with the pathogenesis of MD.…”

Section: Introductionmentioning

confidence: 99%

Absence of COCH mutations in patients with Meniere disease

et al. 2004

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Missense mutations in the coagulation factor C homology (COCH) gene (14q12 -q13) cause the autosomal dominant sensorineural hearing loss and vestibular disorder DFNA9 (OMIM 603196), and a high prevalence of symptoms of Meniere disease (MD) has been described in families with a mutation in the COCH gene. In this study, we search for mutations in the COCH gene in peripheral blood from patients with definite MD. DNA was extracted from peripheral blood cells of 30 individuals with MD and 30 controls. Exons 4 and 5 of the COCH gene were amplified by PCR reaction, using primer pairs flanking both exons. Sequences were analysed by a DNA sequencing system and compared with the published COCH cDNA sequence. No differences were found in the nucleotide sequences of exons 4 and 5 in the COCH gene in patients with definite sporadic MD when they were compared with the control group. Patients with definite MD have a low prevalence of mutations in exons 4 and 5 of the COCH gene.

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HLA antigens in the pathogenesis of Menière's disease

Cited by 77 publications

References 8 publications

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Elevated Antithyroid Peroxidase and Antinuclear Autoantibody Titers in Ménière’s Disease Patients: More than a Chance Association?

Possible association between thyroid autoimmunity and Menière's disease

Absence of COCH mutations in patients with Meniere disease

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