HLA antigens in Tlingit Indians with rheumatoid arthritis

Nelson, J. Lee; Boyer, Georgiana S.; Templin, David; Lanier, Anne P.; Barrington, Robert A.; Nisperos, Brenda; Smith, Anajane G.; Mickelson, Eric; Hansen, John A.

doi:10.1111/j.1399-0039.1992.tb01960.x

Cited by 45 publications

(17 citation statements)

References 28 publications

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“…Populations tested in the present studies are encircled. Data for other populations were obtained from the following publications: Tlingits (Nelson et al 1992); Filipinos (Bugawan et al 1994);Cayapas (Titus-Trachtenberg et al 1994); Tobas, Toba-Pilagas, Mataci-Wichis (Cerna et al 1993); Madangese, Rabaulans, New Caledonians, Fijians,and Papua New Guinean (PNG) highlanders ); Raratongans, Niues, Samoans, Nauruans, Javanese, and Kiribatians (Gao et al 1992b). The data for the Chinese, Japanese, North (N).…”

Section: Phylogenetic Analysismentioning

confidence: 99%

Polymorphism of the HLA class II loci in Siberian populations

et al. 1998

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The populations that colonized Siberia diverged from one another in the Paleolithic and evolved in isolation until today. These populations are therefore a rich source of information about the conditions under which the initial divergence of modern humans occurred. In the present study we used the HLA system, first, to investigate the evolution of the human major histocompatibility complex (MHC) itself, and second, to reveal the relationships among Siberian populations. We determined allelic frequencies at five HLA class II loci (DRB1, DQA1, DQB1, DPA1, and DPB1) in seven Siberian populations (Ket, Evenk, Koryak, Chukchi, Nivkh, Udege, and Siberian Eskimo) by the combination of single-stranded conformational polymorphism and DNA sequencing analysis. We then used the gene frequency data to deduce the HLA class II haplotypes and their frequencies. Despite high polymorphism at four of the five loci, no new alleles could be detected. This finding is consistent with a conserved evolution of human class II MHC genes. We found a high number of HLA class II haplotypes in Siberian populations. More haplotypes have been found in Siberia than in any other population. Some of the haplotypes are shared with non-Siberian populations, but most of them are new, and some represent "forbidden" combinations of DQA1 and DQB1 alleles. We suggest that a set of "public" haplotypes was brought to Siberia with the colonizers but that most of the new haplotypes were generated in Siberia by recombination and are part of a haplotype pool that is turning over rapidly. The allelic frequencies at the DRB1 locus divide the Siberian populations into eastern and central Siberian branches; only the former shows a clear genealogical relationship to Amerinds.

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Section: Phylogenetic Analysismentioning

confidence: 99%

Polymorphism of the HLA class II loci in Siberian populations

et al. 1998

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“…Further, a trend toward an association of DRB1*0901 with RA was reported in the Tlingit of Alaska, another North American Native group, and we previously found a possible association in North American Native patients with rheumatoid factor (RF)-positive polyarticular juvenile rheumatoid arthritis 3,10 .…”

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confidence: 92%

Immunogenetic Risks of Anti-Cyclical Citrullinated Peptide Antibodies in a North American Native Population with Rheumatoid Arthritis and Their First-degree Relatives

El-Gabalawy¹,

Robinson²,

Hart³

et al. 2009

J Rheumatol

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An independent association of the non-SE allele DRB1*0901 with RA was confirmed in this population, and this allele in combination with a SE allele was associated with younger age at disease onset. FDR of RA probands have a higher prevalence of anti-CCP antibodies than more distant relatives and unrelated controls, suggesting a gradient of risk for disease development. Immunogenetic risks may act early in disease pathogenesis at the level of initiation of RA autoantibody formation; however, it is not clear what additional genetic and environmental risks are involved in progression to clinical disease.

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“…In NAN populations, SE-bearing alleles are primarily HLA-DRB1*1402 and *0404. [6][7][8][9][10] High background population frequencies of the SE may, in part, explain the higher prevalence rates of RA in NAN populations, compared with other populations. For example, frequencies of the SE vary from 28 to 38% in United States and United Kingdom Caucasians, but frequencies as high as 60 to 95% have been reported in several NAN populations, where they have been studied.…”

Section: Introductionmentioning

confidence: 99%

Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population

et al. 2011

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Most of the genetic risk for rheumatoid arthritis (RA) is conferred by 'shared epitope' (SE), encoding alleles of HLA-DRB1. Specific North American Native (NAN) populations have RA prevalence rates of 2-5%, representing some of the highest rates estimated worldwide. As many NAN populations also demonstrate a high background frequency of SE, we sought to determine whether other genetic factors contribute to disease risk in this predisposed population. RA patients (n ¼ 333) and controls (n ¼ 490) from the Cree/Ojibway NAN population in Central Canada were HLA-DRB1 typed and tested for 21 single-nucleotide polymorphisms (SNPs) that have previously been associated with RA, including PTPN22, TRAF1-C5, CTLA4, PADI4, STAT4, FCRL3, CCL21, MMEL1-TNFRSF14, CDK6, PRKCQ, KIF5A-PIP4K2C, IL2RB, TNFAIP3, IL10-1082G/A and REL. Our findings indicate that SE is prevalent and represents a major genetic risk factor for RA in this population (82% cases versus 68% controls, odds ratio ¼ 2.2, 95% confidence interval 1.6-3.1, Po0.001). We also demonstrate that in the presence of SE, the minor allele of MMEL1-TNFRSF14 significantly reduces RA risk in a dominant manner, whereas TRAF1-C5 increases the risk. These findings point to the importance of non-HLA genes in determining RA risk in a population with a high frequency of disease predisposing HLA-DRB1 alleles.

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HLA antigens in Tlingit Indians with rheumatoid arthritis

Cited by 45 publications

References 28 publications

Polymorphism of the HLA class II loci in Siberian populations

Polymorphism of the HLA class II loci in Siberian populations

Immunogenetic Risks of Anti-Cyclical Citrullinated Peptide Antibodies in a North American Native Population with Rheumatoid Arthritis and Their First-degree Relatives

Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population

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