2024
DOI: 10.3390/biomedicines12061347
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HLA Association among Thai Patients with Diffuse and Limited Cutaneous Systemic Sclerosis

Worawit Louthrenoo,
Nuntana Kasitanon,
Antika Wongthanee
et al.

Abstract: This study aimed to clarify the association of HLA Class I and II with dcSSc and lcSSc in Thais. HLA typing for 11 gene loci (Class I: HLA-A, B and C, and Class II [HLA-DR, DP and DQ]) was carried out using the Next Generation DNA Sequencing method (three fields) in 92 Thai patients with systemic sclerosis (55 dcSSc, 37 lcSSc) and 135 healthy controls (HCs). The distribution of HLA alleles in patients with dcSSc and lcSSc was compared. When compared with HCs, the AF of A*24:02:01, A*24:07:01, B*27:04:01 and B*… Show more

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