HLA association with biliary atresia in north India

Bala, Madhu; Kanojia, Ravi P.; Minz, Ranjana Walker; Bhatia, Alka; Ram, Anil Kumar; Menon, Prema; Lal, Sadhna; Kumar, Yashwant

doi:10.4103/ijmr.ijmr_1145_21

Indian Journal of Medical Research

2022

DOI: 10.4103/ijmr.ijmr_1145_21

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HLA association with biliary atresia in north India

Madhu Bala

Ravi P. Kanojia

Ranjana Walker Minz

et al.

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2024

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Design, Synthesis, Anti‐Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple‐Negative Breast Cancer

Preeti,

Raza,

Sharma

et al. 2024

Chemistry & Biodiversity

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A series of 1H‐1,2,3‐triazole‐tethered spirocyclopropyl oxindole‐isatin hybrids were synthesized using a copper‐promoted click reaction and evaluated for their anti‐proliferative activities against triple‐negative breast cancer cell lines. The most potent compound in the series outperformed tamoxifen and 5‐fluorouracil, with selectivity indices (SI) of 1.60 and 1.99 against MDA‐MB‐468 and MDA‐MB‐231 cancer cells, respectively. The Caspase 3/7 7‐AAD assay showed live cell populations of 72.10% and 49.20% after 24 and 48 hours, respectively, indicating that the cytotoxic effect is mediated through the caspase apoptotic pathway. Molecular docking studies further suggested the compound's potential as an EGFR inhibitor, highlighting its promise as a therapeutic agent.

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Design, Synthesis, Anti‐Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple‐Negative Breast Cancer

Preeti,

Raza,

Sharma

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

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HLA association with biliary atresia in north India

Cited by 1 publication

References 31 publications

Design, Synthesis, Anti‐Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple‐Negative Breast Cancer

Design, Synthesis, Anti‐Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple‐Negative Breast Cancer

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