HLA Associations in a Cohort of Children With Juvenile Idiopathic Arthritis With and Without Uveitis

Abstract

We report the novel finding that carriage of HLA-DRB1*11 and *13 appears to increase the risk of uveitis in children with JIA.

Identification of an Amino Acid Motif in HLA–DRβ1 That Distinguishes Uveitis in Patients With Juvenile Idiopathic Arthritis

“…Interrogation of larger sample collections and extensive functional work in this region will be necessary to fully understand the mechanism(s) driving the association. Nevertheless, our findings indicate that, although JIA with uveitis and JIA without uveitis share clinical features and HLA‐specific genetic risk factors , there appear to be genetic signals that are specific to JIA with uveitis.…”

“…The relatively high frequency of serine 11 in the JIA patients who did not develop uveitis (Table ) indicates the likely involvement of additional (epi)genetic and environmental factors in uveitis. Only a handful of candidate gene studies , HLA‐specific analyses , and a recent GWAS have investigated uveitis as a phenotype separate from JIA overall, with the latter study identifying HLA–DRB1*1501 as a uveitis risk factor. Genes outside the MHC have also been implicated in JIA‐associated uveitis, including a polymorphism in VTCN1 and variants near the immune genes TRAF1 and C5 .…”

“…Our data enabled 3 comparisons: 1) all JIA cases versus population‐level controls, 2) JIA‐associated uveitis cases versus population‐level controls, and 3) JIA‐associated uveitis cases versus non‐uveitis JIA controls. As we sought to compare the genetic architecture of JIA and uveitis, and because far larger GWAS of JIA and population‐level controls have already been completed , we performed the first 2 comparisons for the purposes of quality control and to look up known associations (for more details, see Supplementary Figures 1 and 2 and Supplementary Table 1, available on the Arthritis & Rheumatology web site at http://onlinelibrary.wiley.com/doi/10.1002/art.40484/abstract). We accounted for these comparisons when considering multiple testing.…”

Uveitis associated with juvenile idiopathic arthritis

“…Исследование случай-контроль с участием 107 пациентов европеоидной расы с олигоартритом и РФ-негативным полиартритом показало связь носительства аллелей HLA-DRB1*11 и *13 с развитием увеита: ОШ 9,0 (95% ДИ 2,8-29,0) по сравнению со здоровыми лицами и ОШ 8,6 (95% ДИ 1,0-74,4) по сравнению с группой с изолированным ювенильным идиопатическим артритом [7]. В ряде работ, в том числе отечественных, показаны ассоциации HLA-А2 и HLA-DR5 / HLA-DRB1*11 с ранним началом олигоартрита у девочек и риском развития увеита [8].…”

Prospective Determination of the Incidence and Risk Factors of New‐Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort

“…Although previous studies have shown that uveitis develops most frequently early in the disease , there are very limited data about its precise risk during the course of JIA. The annual incidence (rate of occurrence of new cases in a given year) after JIA diagnosis is more informative about the risk of uveitis than frequency estimates over a reference period of time.…”