HLA B13, B17, B37 and Cw6 in psoriasis vulgaris: Association with the age of onset

Psoriasis vulgaris has HLA associations. We have previously defined HLA-Cw6,DR7,DQA1*0201 as the central element of the risk haplotypes for psoriasis. On the other hand, Cw6 as a single gene has the strongest association with psoriasis. The aim of this study was to determine whether the risk haplotype and Cw6 correlate with the clinical parameters of the disease. The series consisted of 64 patients and the clinical parameters were age at onset, family history of psoriasis, arthritis and the frequency of inpatient treatment. The HLA risk haplotype Cw6,DR7,DQA1*0201 had previously been found in 30% and Cw6 alone in 54% of the patients. The presence of Cw6 correlated with early age at onset (Pc = 0.01). The presence of the risk haplotype correlated with a positive family history of psoriasis among the first-degree relatives (Pc = 0.02) and an overall positive family history (Pc = 0.04), but Cw6 had a stronger correlation with an overall positive family history (Pc = 0.01). There were no positive correlations with arthritis or the number of inpatient treatment periods. Only type I psoriasis was associated with Cw6 (Pc = 0.0006). In conclusion, Cw6 and the haplotype Cw6,DR7,DQA1*0201 are important in the heredity of psoriasis vulgaris, but the presence of Cw6 alone is sufficient to indicate a clinically significant risk for psoriasis.

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“…The results are in accordance with earlier reports on the relationship between HLA and age at onset [2,6,9].…”

Section: Discussionsupporting

confidence: 95%

HLA risk haplotype Cw6,DR7, DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis vulgaris

Ikäheimo¹,

Tiilikainen²,

Karvonen³

et al. 1996

Arch Dermatol Res

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“…These patients have an irregular disease course, which shows a strong tendency to become generalized and severe [3, 35]. These findings, as well as the strong association of early-onset psoriasis with HLA-Cw6 [35,36,37], has led some investigators to postulate that there are in fact two separate types of psoriasis [32]. The results of our study would certainly lend indirect support to this idea.…”

Section: Discussionsupporting

confidence: 61%

What Characterizes the Severity of Psoriasis?

García‐Diez¹,

Foraster²,

Sebastian³

et al. 2008

Dermatology

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Background: Understanding the epidemiology of moderate-to-severe psoriasis is essential for its management. Objective:To assess the epidemiological characteristics of patients with moderate-to-severe psoriasis. Methods: Cross-sectional, observational epidemiological study conducted in Spain and Portugal. Data were collected by 332 dermatologists for ≧10 consecutive presenting patients. Results: Based on body surface area (BSA) and Psoriasis Area and Severity Index (PASI) criteria, moderate-to-severe psoriasis was confirmed in ≧79.3% of patients (n = 3,320). Preexisting comorbid conditions included psoriatic arthropathy (13%), dyslipidemia (14.1%) and hypertension (20.2%). The mean BSA involvement was 23% (95% confidence interval, CI: 22.2–23.3%), and the mean PASI score was 14.3 (95% CI: 13.9–14.6%). During the 2 years prior to assessment, 97.0% of patients had received topical treatments, whereas 31.3% had not received systemic treatment or phototherapy. The median annual cost of treatment was 825 EUR. Conclusion: Moderate-to-severe psoriasis is accurately diagnosed, but inadequately treated in many patients in Spain and Portugal.

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“…Percentages for the guttate form were higher, but the numbers involved were too small to draw conclusions, and they considered that both forms did not differ significantly in the presence of Cw6. Brenner et al [10] reported a strong positive association of early onset with HLA-Cw6, testing one group with age of onset of 10-20 years and another with age of onset of 35-45 years. Suarez-Almazor and Russell [11] suggested an association between the development of Ps and the familial inheritance of a particular haplotype but did not discuss age of onset.…”

Section: Introductionmentioning

confidence: 99%

Bimodality in Age of Onset of Psoriasis, in Both Patients and Their Relatives

et al. 1993

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The ages at onset of 245 female and 211 male psoriasis (Ps) patients were recorded. The distribution of age of onset in both sexes is bimodal, with separation at the age of 40 years into an early-onset group and a late-onset group. These distributions were normal (Gaussian) with equal variances. These data are compatible with the hypothesis that there are two genotypes for Ps. Further evidence for this hypothesis is provided by the relationship between age of onset and number of affected relatives. The latter, corrected for age at time of study, demonstrates a mixture of two negative binomial distributions, also with likely separation at the age of 40 years. The age distribution of Ps patients reflects the bimodality of age of onset, but with larger means and variances.

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HLA B13, B17, B37 and Cw6 in psoriasis vulgaris: Association with the age of onset

Cited by 73 publications

References 3 publications

HLA risk haplotype Cw6,DR7, DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis vulgaris

HLA risk haplotype Cw6,DR7, DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis vulgaris

What Characterizes the Severity of Psoriasis?

Bimodality in Age of Onset of Psoriasis, in Both Patients and Their Relatives

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