HLA-B27 and the Link with Rheumatic Diseases: Recent Developments

Ebringer, R.

doi:10.1042/cs0590405

Cited by 12 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The second example of another microbial-host interaction that is, to say the least, intriguing involves the reaction between Klebsiella spp. (and other similar organisms) and the HLA antigens B27, as described by Ebringer (1981) and Geczy al. (1980).…”

Section: Other Examplesmentioning

confidence: 97%

Immunopathological mechanisms in bacterial-host interactions

Zabriskie

Tabaqchali²

1983

Phil. Trans. R. Soc. Lond. B

View full text Add to dashboard Cite

The ability of bacteria to cause immunopathological damage in the host may take a variety of forms. These pathways may be conveniently grouped under three major headings: (1) organisms that can cause damage via shared antigenic determinants between host and bacterium; (2) those organisms that suppress the host’s response; and (3) organisms that release substances with specific biological properties or have receptors for specific tissue sites. The group A streptococcus is among the most versatile of these bacteria because it appears that it may use all three pathways in various streptococcal-related disease states. In rheumatic fever and chorea it appears that cross-reactive antigens play a major role in inducing immunopathological damage in that there is both a heightened humoral and cellular reaction by the host to these cross-reactive determinants. Recent evidence also indicates that rheumatic fever individuals express certain B cell antigens that may be associated with susceptibility to the disease. In the other complications of streptococcal infections, namely poststreptococcal glomerulonephritis, the bacterium uses both suppression of the host’s immune response and the excretion of a particular protein common to all nephritis-associated strains to achieve its immunopathological damage. In this context, other examples of bacterial-host interactions will be discussed as evidence for the common pathways used by microbes to cause immunopathological damage in the host.

show abstract

Section: Other Examplesmentioning

confidence: 97%