HLA-B51 may serve as an immunogenetic marker for a subgroup of patients with Behcet's syndrome

Chajek-Shaul, Tova; Pisanty, Sara; Knobler, H; Matzner, Yaacov; Glick, Michael; Ron, Noemi; Rosenman, Eliezer; Brautbar, Chaim

doi:10.1016/0002-9343(87)90896-5

Cited by 75 publications

(25 citation statements)

References 18 publications

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“…2 An association between Behçet's disease and HLA-B51 has been regarded as the strongest evidence for involvement of genetic factors in the pathogenesis, and this association has been confirmed in different ethnic groups with varying strength. [3][4][5][6][7][8][9] By molecular genetic analysis of the major histocompatibility complex (MHC) region, it has been suggested that HLA-B51 might not be pathogenic itself, but indicate linkage disequilibrium with a putative susceptibility gene very close to the HLA-B locus. [10][11][12][13][14] Several novel genes have been identified by investigation of the region between the tumor necrosis factor (TNF) and HLA-B loci.…”

Section: Introductionmentioning

confidence: 99%

A weak association of HLA-B*2702 with Behçet’s disease

et al. 2002

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Section: Introductionmentioning

confidence: 99%

A weak association of HLA-B*2702 with Behçet’s disease

et al. 2002

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“…Aseptic neutrophi1 infiltration in the lesions is one of the most striking pathologic features, and various in vitro tests of neutrophil function in patients with BehGet's disease have been shown to be abnormal (1)(2)(3)(4)(5). This suggests that the excessive neutrophil function plays a vital role in the development and clinical course of the disease.…”

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confidence: 99%

Excessive function of peripheral blood neutrophils from patients with behcet's disease and from hla‐b51 transgenic mice

Takeno

Kariyone

Yamashita

et al. 1995

Arthritis & Rheumatism

191

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Objective. To elucidate the role played by HLA-B51 in the neutrophil hyperfunction of Behqet's disease, we determined the superoxide production by purified peripheral blood neutrophils from Behqet's disease patients, from HLA-B51 positive healthy individuals, and from HLA-B51 transgenic mice, Methods. Neutrophil function was evaluated by flow cytometric analysis, detecting the conversion of 2',7'-dichlorofluorescin diacetate into dichlorofluorescein, induced by superoxide in the neutrophils.Results. A significant correlation between the neutrophil hyperfunction and the possession of HLA-B51 phenotype, regardless of the presence of the disease, was observed in humans. FMLP-stimulated neutrophils (without in vitro priming) from HLA-BS1 transgenic mice, but not those from HLA-B35 transgenic mice or from nontransgenic mice, produced substantial amounts of superoxide.Conclusion. The HLA-BS1 molecule itself may be responsible, at least in part, for neutrophil hyperfunction in Behqet's disease.

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“…The genetic association of HLA-B5 (B51) with BD was initially reported in 1973 by Ohno and coworkers [24]. Subsequently this association has been confirmed in many different ethnic populations in Asia (Japanese [16,[24][25][26][27][28], Korean [29,30], Han Chinese [31], Taiwan Chinese [32], Turk [33][34][35][36][37], Israeli [38][39][40], Palestinian and Jordanian [41], Iranian [42], and Iraqi [43]), Southern Europe (Italian [44][45][46], Greek [47][48][49], Spanish [50], and German [17,51]), Northern Africa (Moroccan [55] and Tunisian [56]), North America (Mexican [59]), and South America (Brazilian [60]), but not in some populations in Northern Europe (British [35,52,53]) and North America (American [57,58]) ( Table 1). Although the odds ratio (OR) for the susceptibility risk of BD among carriers of HLA-B51 has been known to be much higher in the ethnic groups who live in endemic areas along the ancient Silk Road than in the American or British populations, recently published data have shown that the HLA-B51-associated risk could be significantly raised even among some other populations outside the ancient tradin...…”

Section: Mhc Genes (A) Hla-b51 Antigenmentioning

confidence: 99%

Update on the Molecular Genetic Studies of Behcets Disease

Chang

2005

CRR

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Although the pathogenesis of Behcet's disease (BD) is not fully elucidated, a genetic susceptibility to the disease appears to be affected by a polygenic inheritance, including the major histocompatibility complex (MHC) and non-MHC genes. As is true for the well-known regional differences in the disease expression of BD, a genetic susceptibility to BD appears to be different in various ethnic groups. Although HLA-B51 is a genetic factor with the strongest association in most ethnic populations who reside in countries adjacent to the ancient Silk Road, it is still uncertain whether this HLA molecule is directly involved in the pathogenesis of BD. In addition to HLA-B51, the association of BD with the MICA gene has been reported to be the consequence of linkage disequilibrium with HLA-B51, whereas the TNF-1031C allele among TNF gene polymorphisms has been observed to be another risk factor independent of the presence of HLA-B51 in UK Caucasoid patients with BD. Recently, intensive investigations on non-MHC genes, some of which are noted to be associated with a susceptibility to BD in several ethnic groups, are under way.

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HLA-B51 may serve as an immunogenetic marker for a subgroup of patients with Behcet's syndrome

Cited by 75 publications

References 18 publications

A weak association of HLA-B*2702 with Behçet’s disease

A weak association of HLA-B*2702 with Behçet’s disease

Excessive function of peripheral blood neutrophils from patients with behcet's disease and from hla‐b51 transgenic mice

Update on the Molecular Genetic Studies of Behcets Disease

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