HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes

Shimizu, Tetsunosuke; Tashiro-Yamaji, Junko; Hayashi, Michihiro; Inoué, Yoshihiro; Ibata, Minenori; Kubota, Takeshi; Tanigawa, Nobuhiko; Yoshida, Ryotaro

doi:10.1016/j.gene.2010.01.007

Cited by 6 publications

(19 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7), revealing that mouse PBMCs had MMR1 or MMR2 for non-self MHCs. In contrast, human MMR2 mRNA was earlier reported to be expressed in PBMCs from 8 of the 16 healthy volunteers, although PBMCs from only 4 of these volunteers expressed HLA-B62 (Shimizu et al, 2010). Similarly, none of the 16 volunteers expressed HLA-B44, whereas PBMCs from only 3 volunteers [i.e., A(11,24)B(51,52); A(2,24)B(46,46); A(2,2) B(60,60)] expressed human MMR1 mRNA (Fig.…”

Section: Human or Mouse Mmr1 Mrna Expression In Pbmcs Or Monocytesmentioning

confidence: 86%

“…3-5;Shimizu et al, 2010;TashiroYamaji et al, 2006a,b). The amino-acid sequence of whole human MMR2 protein is highly conserved among mammals (84-98%) but not among invertebrates (27-30%); and the amino-acid sequence of the HLA-B62-binding region is considerably conserved (64.8-95.1%) only in mammals but not (≤20.4%) in invertebrate animals (Shimizu et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Mouse MMR2 mRNA is expressed in PBMCs from non-H-2K d (non-self), but not H-2K d (self), in-bred mice (Shimizu et al, 2010). Similarly, mouse MMR1 mRNA was expressed in PBMCs The putative R15 mAb-or HLA-B44 tetramer-binding site and transmembrane domains are dot-underlined and underlined, respectively.…”

Section: Human or Mouse Mmr1 Mrna Expression In Pbmcs Or Monocytesmentioning

confidence: 99%

“…As human MMR2 is expressed at least in part in the brain and peripheral blood cells (Shimizu et al, 2010), we performed RT-PCR using total RNAs from human brain and PBMCs and appropriate primer sets to isolate human MMR1 cDNA and to examine mRNA expression of human MMR1 in human tissues (Fig. 1).…”

Section: Isolation Of a Human Cdna Homologous To Mouse Mmr1 By Rt-pcrmentioning

confidence: 99%

“…Recently, we isolated 2 cDNA clones encoding novel MHC receptors on AIM for allogeneic MHCs (H-2D d and H-2K d ) by using anti-AIM monoclonal Abs (mAbs; R15 and R12) and H-2D d and H-2K d tetramers and called them macrophage MHC receptor 1 (MMR1) and MMR2 (Tashiro-Yamaji et al, 2006a,b). More recently, we isolated a cDNA encoding the human homologue of mouse MMR2, a ligand of which is human leukocyte antigen (HLA)-B62 (Shimizu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations