HLA—Bw35 and Prognosis in Adult Still's Disease

Terkeltaub, Robert; Esdaile, John M.; Décary, Francine; Harth, Manfred; Lister, John; Lapointe, Normand

doi:10.1002/art.1780241203

Cited by 54 publications

(26 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The nearly complete absence of Bw35 in the present series, which is probably due to a linkage disequilibrium of Bw35 with DR1, contrasts strongly with the results of Glass and Litrin (5) and Terkeltaub (9), who reported a significantly increased incidence of Bw35 in juvenile-and adult-onset Still's disease patients, respectively. In addition, since none of our 16 patients with self-limited disease, defined in the same way as Terkeltaub did (9), was positive for Bw35, we cannot support Terkeltaub's suggestion that Bw35 may be a favorable prognostic marker in AOSD.…”

Section: Discussioncontrasting

confidence: 81%

“…Previous HLA studies in juvenile patients with Still's disease have shown increased frequencies of B8 (3, Bw35 (5,6), Bw44 (6), DR4 (6), DR5 (7), and Dw7 (8). In adult patients, B14 (6), Bw35 (9), Cw4 (9), and DR7 (6) were reported to be increased (Table 3).…”

Section: Discussionmentioning

confidence: 83%

“…In adults, an increased frequency of B14 (6), Bw35 (9), Cw4 (9), and DR7 (6) has been found. This study reports on HLA phenotypes in 42 patients with AOSD, and includes radiologic features and disease course.…”

Section: P = 003) Compared With the Patients Without Involvement Of mentioning

confidence: 93%

See 2 more Smart Citations

Adult‐onset still's disease. Disease course and HLA associations

Wouters¹,

Reekers²,

Putte³

1986

Arthritis & Rheumatism

View full text Add to dashboard Cite

Disease course and HLA antigens were determined in 29 patients with definite and 13 patients with probable adult-onset Still's disease (AOSD). Twenty-six patients had persistent disease with continuous disease activity for at least 1 year. Radiographic examination revealed evidence of joint destruction in 26 patients. In 15 patients, at least 1 root joint was impaired. The frequency of DR4 was increased in the total group of patients (35%, P = 0.03) and in the 29 patients with definite AOSD (41%, P = 0.02) compared with the frequency in normal controls (20%). None of the patients was positive for DR1, and only l was positive for Bw35. The frequency of DRw6 was increased in the patients with involvement of at least 1 root joint (40%,

show abstract

Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Adult‐onset still's disease. Disease course and HLA associations

Wouters¹,

Reekers²,

Putte³

1986

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Consistent with this classification, strong associations with MHC class II are lacking in AOSD, although in some populations association with HLA-DR4, HLA-Bw35, or HLA-DRB1 have been occasionally observed [26,27]. Polymorphisms have been described in genes encoding innate immunity-associated factors and cytokines, such as IL-6, IL-1a, IL1-RN, macrophage inhibitory factor (MIF), or TNF in patients with sJIA [28][29][30] and IL-18, or MIF in patients with AOSD [31,32].…”

Section: Geneticsmentioning

confidence: 57%

Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart

et al. 2014

View full text Add to dashboard Cite

Adult-onset Still's disease (AOSD) is a rare inflammatory disease characterized by the classical triad of daily fever, arthritis, and typical salmon-colored rash. Recent accumulation of knowledge, mostly arising from hereditary autoinflammatory diseases and from the systemic-onset juvenile idiopathic arthritis (sJIA), has given raise to new hypotheses on the pathophysiology of AOSD. In this review, we first discuss on the continuum between AOSD and sJIA. Then, we summarize current hypotheses on the underlying pathogenesis: (1) an infectious hypothesis; (2) an autoinflammatory hypothesis; (3) a lymphohistiocytic hypothesis; and (4) a hyperferritinemic hypothesis. Finally, we present the recent data suggesting that patients with AOSD fall into two distinct subgroups with different courses, one with prominent systemic features and one with chronic arthritis.

show abstract

“…HLA-DRB1*04 may be protective of the disease, whilst HLA-Bw35 conferred a better prognosis 6 . HLA-DRB1*14 alleles were more common in patients with the monocyclic systemic type of AOSD 7 , whilst chronic articular form of the disease was associated with HLA-DR2, DR5 and DQ1 alleles 8 .…”

Section: Epidemiologymentioning

confidence: 99%

Adult-Onset Still's Disease: A Review

Fong

Lui

2013

Proceedings of Singapore Healthcare

View full text Add to dashboard Cite

Adult-onset Still's disease (AOSD) is an uncommon inflammatory condition characterised by high fever, leukocytosis with neutrophilia, arthralgia and skin rash. Diagnosis is often clinical, and it is always necessary to exclude common disease mimics such as infections, malignancies and other rheumatic diseases. Ferritin and glycosylated ferritin are useful adjuncts to aid in the diagnosis of AOSD. Important complications to consider include fulminant hepatitis, disseminated intravascular coagulopathy and hemophagocytic syndrome. Mainstay treatment of AOSD is often with glucocorticoids. Other agents that can also be used include methotrexate, and biologic therapy, such as tumor necrosis factor-α (TNF-α) blockers and interleukin-1 (IL-1) inhibitors. A retrospective review of patients diagnosed with AOSD admitted to Singapore General Hospital (SGH) was performed, and their disease characteristics and laboratory findings were compared with that of previous published cohorts.

show abstract

HLA—Bw35 and Prognosis in Adult Still's Disease

Cited by 54 publications

References 16 publications

Adult‐onset still's disease. Disease course and HLA associations

Adult‐onset still's disease. Disease course and HLA associations

Pathogenesis of adult-onset Still’s disease: new insights from the juvenile counterpart

Adult-Onset Still's Disease: A Review

Contact Info

Product

Resources

About