HLA-C*01:02 and HLA-A*02:07 Confer Risk Specific for Psoriatic Patients in Southern China

Cai, Minglong; Huang, He; Ran, Delin; Zheng, Xiaodong; Wen, Leilei; Zhu, Zhengwei; Liu, Lu; Zhang, Chuanliang; Hong, Xiaojie; Hong, Jiaqi; Wu, Wenjuan; Ma, Jie; Wu, Ming‐Shun; Qian, Danfeng; Sheng, Yujun; Zhang, Xuejun

doi:10.1016/j.jid.2019.02.027

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…There is evidence supporting the association between HLA-Cw1 and psoriatic diseases in different ethnic groups (Table 1), especially in Thai [12] and Southern China populations [11]. In Thai patients, the HLA-Cw1 allele frequency of type I early-onset psoriasis compared with controls was 35% vs 16% (p < 0.05) [13].…”

Section: Hla-cw1 Allele Frequency In Patients With Psoriasismentioning

confidence: 80%

“…A summary of characteristics of patients with psoriasis carrying HLA-Cw1 in comparison to HLA-Cw6 is provided in Table 2. HLA-Cw6 is the most well-recognized HLA serotype, affecting susceptibility, phenotype, disease Ethnicities Kuwait [15] All ethnicities (higher in Caucasians) Pakistan [16] Singapore Chinese [17] Southern Chinese [11] Thai [12] Turkish [14] Phenotypes…”

Section: Discussionmentioning

confidence: 99%

“…In a study that compared the HLA susceptibility of 4493 patients with psoriasis and 4649 controls from Southern China, and 3657 patients with psoriasis and 5257 controls from Northern China, HLA-C*06:02 and HLA-C*07:04 were significantly increased in both patient groups. However, HLA-C*01:02 (OR = 1.32, p = 2.45 × 10 -7 ) and HLA-A*02:07 (OR = 1.67, p = 2.49 × 10 -11 ) were associated with an increased risk of psoriasis only in patients from Southern China using a logistic regression and stepwise conditional analysis [11]. HLA-C*06:02 and HLA-C*07:04 showed similarities in peptide binding preference [41], whereas HLA-C*01 and HLA-A*02 [42] have very similar binding motifs, suggesting possible yet unidentified antigen/autoantigens in the pathogenesis of patients with psoriasis with HLA-Cw1 positivity.…”

Section: Hla-cw1 Allele Frequency In Patients With Psoriasismentioning

confidence: 99%

“…The effect of other HLA-Cw alleles on psoriasis is less studied. Recently, HLA-C*01:02 and HLA-A*02:07 were reported to confer a specific risk for psoriatic patients in Southern China [11]. HLA-C*01 has also been identified as a common HLA-C in some other ethnicities [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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HLA-Cw1 and Psoriasis

Huang

Tsai

2021

Am J Clin Dermatol

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Psoriasis is a chronic inflammatory skin condition with regional and ethnic differences in its prevalence and clinical manifestations. Human leukocyte antigen (HLA)-Cw6 is the disease allele conferring the greatest risk to psoriasis, but its prevalence is lower in Asian individuals. Recent studies have found associations between HLA-Cw1 and some Asian populations with psoriasis, especially Southern Chinese. HLA-Cw6 was associated with type I early-onset psoriasis, guttate psoriasis, Koebner phenomenon, and better response to methotrexate, interleukin (IL)-12/23, IL-17, and IL-23 targeting drugs. In contrast, HLA-Cw1 positivity has been associated with erythrodermic psoriasis, pustular psoriasis, and the axial type of psoriatic arthritis. Furthermore, HLA-Cw1 was more frequently associated with high-need patients who did not respond to conventional therapies. No known trigger factor nor autoantigen has been identified for HLA-Cw1 positivity. However, HLA-Cw1 has been linked to some viral agents. For example, cytotoxic T lymphocytes recognize multiple cytomegalovirus pp65-derived epitopes presented by HLA alleles, including HLA-C*01:02. In addition, cytomegalovirus can lead to severe exacerbation of psoriatic skin disease. The proposed interaction between viral infection, HLA-Cw1, and psoriasis is through the killer cell immunoglobulin-like receptors of natural killer cells. Given the diverse nature of psoriasis pathogenesis and the difference in HLA-Cw prevalence in different racial groups, more studies are needed to confirm the role of HLA-Cw1 in psoriasis. Key PointsHuman leukocyte antigen (HLA)-Cw1 is a less recognized but important HLA-Cw allele associated with psoriasis in some Asian ethnicities.Patients carrying HLA-Cw1 tend to show higher disease activity, have an increased risk of developing erythrodermic psoriasis, and are more refractory to treatments.

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Section: Hla-cw1 Allele Frequency In Patients With Psoriasismentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Hla-cw1 Allele Frequency In Patients With Psoriasismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HLA-Cw1 and Psoriasis

Huang

Tsai

2021

Am J Clin Dermatol

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“…As expected, in the fine-mapping analysis of SP (5,262 SP cases vs. 9,906 controls), we observed HLA-C ∗ 06:02 (OR = 15.16, P = 1.00 × 10 −863 , Figure 2 , Table 3 ) as the most significantly SP-associated allele, followed by HLA-C ∗ 07:04 (OR = 3.89, P = 5.35 × 10 −27 ). After the condition on HLA-C ∗ 06:02 and HLA-C ∗ 07:04 , we found an independent association for HLA-C ∗ 01:02 (OR = 1.29, P = 8.35 × 10 −8 ), which was recently reported to be associated with psoriasis in southern China [ 27 ]. We then investigated additional risk variants independent of HLA-C .…”

Section: Resultsmentioning

confidence: 64%

Two Variants in the NOTCH4 and HLA-C Genes Contribute to Familial Clustering of Psoriasis

Cai

Huang

et al. 2020

International Journal of Genomics

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Psoriasis is a multifactorial immune-mediated skin disease with a strong genetic background. Previous studies reported that psoriasis with a family history (PFH) and sporadic psoriasis (SP) have a distinct manifestation and genetic predisposition. However, the genetic heterogeneity of PFH and SP in the major histocompatibility complex (MHC) region has not been fully elucidated. To explore genetic variants in the MHC region that drive family aggregation of psoriasis, we included a total of 8,127 psoriasis cases and 9,906 healthy controls from Han Chinese and divided psoriasis into two subtypes, PFH ( n = 1,538 ) and SP ( n = 5,262 ). Then, we calculated the heritability of PFH and SP and performed a large-scale stratified association analysis. We confirmed that variants in the MHC region collectively explained a higher heritability of PFH (16.8%) than SP (13.3%). Further stratified association analysis illustrated that HLA-C ∗ 06:02 and NOTCH4:G511S contribute to the family aggregation of psoriasis, and BTNL2:R281K specifically confers risk for SP. HLA-C ∗ 06:02 and NOTCH4:G511S could partially explain why patients with PFH have a stronger genetic predisposition, more complex phenotypes, and more frequent other autoimmune diseases. The identification of the SP-specific variant BTNL2:R281K revealed that the genetic architecture of SP is not just a subset of PFH.

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Associations between HLA-Cw1 and Systemic Treatment Response of Asian Psoriasis Patients

Tsai

2022

Mol Diagn Ther

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HLA-C01:02 and HLA-A02:07 Confer Risk Specific for Psoriatic Patients in Southern China

Abstract: et al. Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma. Nat Commun 2016;7:12510.

Cited by 9 publications

References 18 publications

HLA-Cw1 and Psoriasis

HLA-Cw1 and Psoriasis

Two Variants in the NOTCH4 and HLA-C Genes Contribute to Familial Clustering of Psoriasis

Associations between HLA-Cw1 and Systemic Treatment Response of Asian Psoriasis Patients

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