HLA class I (-A, -B, -C) and class II (-DR, -DQ) polymorphism in the Mauritanian population

Abstract

BackgroundHLA antigens have been widely studied for their role in transplantation biology, human diseases and population diversity. The aim of this study was to provide the first profile of HLA class I and class II alleles in the Mauritanian population.MethodsHLA typing was carried in 93 healthy Mauritanian blood donors, using single specific primer amplification (PCR-SSP).ResultsOccurrences of the main HLA class I (-A, -B, -C) and class II (-DR, -DQ) antigens in the general population showed that out of the 17 HLA-A allele groups detected, five main HLA-A allele groups: A*02 (18.42%), A*01 (14.04%), A*23 (14.04%), A*30 (13.16%) and A*29 (12.28%) were the most common identified along other 12 relatively minor allele groups. Twenty three allele groups were observed in the locus B of which B*07 (13.46%) was the most prevalent followed by B*15, B*35, B*08 and B*27 all, with a frequency between 7 to 8%. Three prevalent HLA-C allele groups (C*02: 35.09%, C*07: 20.19% and C*06: 13.6%) were detected. The main HLA class II observed allele groups were: DRB1*13 (27.42%), DRB1*03 (24.73%), DRB1*11 (13.98%), DQB1*03 (36.03%), DQB1*02 (22.06%) and DQB1*05 (18.8%). Except for few haplotype in class I (A*02-B*07: 4.45%, A*02-C02: 10%, A*23-C*02: 8.8%, B*07-C*02: 8.8%, B*15-C*02: 8.8%) and in class II (DRB1*13-DQB1*06: 11.94%, DRB1*03-DQB1*02:11.19% and DRB1*03-DQB1*03: 10.45%), the majority of locus combination were in the range of 2–3%. A single predominant haplotype C*02-DRB1*03 (16.67%) was found.ConclusionsThese results, in agreement with previous data using different tissues markers, underlined the ethnic heterogeneity of the Mauritanian population.

Genetic variation of TLR3 gene is associated with the outcome of hepatitis b infection in mauritanian patients: case control study

“…A similar result in our region has been reported for HBV infection in the Tunisian population; with a twofold higher risk of chronic HBV infection in TLR3 rs3775290 (T allele) carriers than in non-mutant controls [ 13 ]. This result is in agreement with previous studies showing a similar prevalence of various biomarkers of disease, reflecting the common ethnicity of the two populations [ 25 ]. Conversely, no overall risk of developing chronic HBV was found in the South China population, where the rs3775290 polymorphism of the TLR3 gene has a protective effect against the development of chronic HBV infection [ 22 ].…”

“…A recent report have highlighted the association between TLR3 rs3775290 and TLR4 rs4986790 and chronic HBV infection within North African population [13]. Mauritania is known for its rich ethnic diversity, which includes multiple racial groups originating from both sub-Saharan Africa and North Africa [25].…”

Epidemiological and Clinicopathological Features of Breast Cancer in Mauritania

“…This ethnically associated repartition of percentages in TNBC also concords with the distribution of other biomarkers we reported previously in our population [39][40]. However, although differences of percentages between TNBC and NTNBC patients were observed, all parameters we analyzed did not reach the level of statistical signi cance set.…”

SARS-CoV-2: Origin, Intermediate Host and Allergenicity Features and Hypotheses

“…Our results show that five human HLA class I alleles and nine human HLA class II alleles can bind tightly with the S protein fragments of SARS-CoV-2, accounting for 0.18% to 24.28% of the sampled Chinese populations (Table 1). Provided that the locus recombination frequencies of 2%-3% are negligible [49], the proportion of infection-susceptible individuals would be about 7.36% of the Chinese population. These data suggest that people who have these HLA genotypes would be severely affected by COVID-19 and develop obvious pathological symptoms if there were no intervention.…”