HLA class I and class II allele distribution in the Peruvian population

Abstract

The distribution of HLA-A, -B, -C, -DRB1 and -DQB1 alleles in the Peruvian population was studied and compared with those of other populations in order to provide further information about their anthropological origin. Our data are consistent with the Mestizo character of this population. In terms of genetic distance Peruvians are closest to Bolivians, which is in agreement with the geographical location and the cultural and anthropological background of the two human groups. Several HLA-B alleles originally described in genetically isolated Amerindian tribes are also present in the sample studied here. This fact and the reported finding of these alleles in several Amerindian groups suggests that they were present in the first wave of humans that populated South America (Paleoindians) before they split to give rise to the different South American tribes.

Chemokine receptor CCR5 polymorphisms and Chagas’ disease cardiomyopathy

“…In addition, the low frequency of CCR5Δ32 allele observed in our population did not allow us to further investigate the possible influence on Chagas’disease outcome. On the other hand, the low distribution of the CCR5Δ32 allele in the Peruvian sample is consistent with its anthropological origin, which is a mestizo population with a strong Amerindian component (18). Similar to our findings various studies have confirmed the low prevalence of the Δ32 allele among Amerindian populations (15, 19, 20), and corroborate the hypothesis that the CCR5Δ32 allele has a European origin, and that its presence in South American populations is probably the result of immigration.…”

Impact of HLA‐DRB1 allele polymorphisms on control of HIV infection in a Peruvian MSM cohort

“…As expected, the most polymorphic locus was DRB1 and DRB1 * 09 : 01 the most common among its allelic variants (25% individuals). These results are in line with the findings from earlier studies across different Amerindian populations and more than double the available data on HLA allele frequencies in the Peruvian population. However, without the ability of better defining the ethnic origin of the participants in the present study beyond the self‐assigned “mestizo” origin, our data do not offer new insights into indigenous population of Peru.…”

Determination of HLA -A, -B, -DRB1 polymorphism in brain dead organ donors representative of the Colombian general population, 2007-2014

“…Los alelos más frecuentes fueron el A*02 (22,5 %) y el A*24 (20,2 %), lo cual coincide con los datos reportados en otros estudios en Colombia, en Latinoamérica y en la población hispana en general, los cuales evidencian que estos dos alelos aparecen con una frecuencia superior al 40 % (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”

“…En el locus B fue posible detectar 43 alelos, de los cuales el 40 % se presentó con frecuencias inferiores a 1 %. Solo el B*35 tuvo una frecuencia superior a 20 %, es decir, fue el más representativo, tal como se ha registrado para la población colombiana y latinoamericana en otros estudios (11)(12)(13)(14)(15)(16)(17)(18)(19).…”