HLA class I and discoveries of the HLA-K (pseudogene) related to disease severity and progression in patients with spondyloarthritis in Dr. Soetomo General Hospital, a tertiary health care center in Surabaya, Indonesia

Yuliasih, Yuliasih; Nisa, Nabilatun; Rahmawati, Lita Diah; Prastayudha, Cahaya

doi:10.12688/f1000research.124416.1

Cited by 2 publications

(1 citation statement)

References 36 publications

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“…Although studies of the correlation between DKK-1 and BMD in SpA have already been reported, there are scant studies comparing these two factors simultaneously, particularly in SpA patients from Indonesia. The major genetic involvement in autoimmune disease, particularly SpA, enables regional variations in disease appearance and development [ 14 ].…”

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confidence: 99%

The Increasing Level of DKK-1 as a New Bone Formation Factor in Patients with Early Spondyloarthritis

Yuliasih,

Permatasari,

Rahmawati

et al. 2023

Autoimmune Diseases

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The role of dickkopf-related protein 1 (DKK-1) in radiographic development may become a robust marker for early spondyloarthritis (SpA) diagnosis. This study aimed at determining the serum DKK-1 profile in patients with SpA and investigating its relationship with SpA progression. Supported by analyzing the BMD data which aims to affirm the potential of DKK-1 as a biomarker for early diagnosis of SpA, this research may become the early study to produce a robust tool to diminish the fatal impacts in SpA. This cross-sectional study included patients with SpA using ASAS 2010 criteria from Dr. Soetomo General Hospital, Indonesia. Collected data included patients’ general characteristics, disease duration, disease activity using ASDAS-CRP and ASDAS-ESR, serum DKK-1 levels, and BMD. The patients were classified as early SpA if the disease duration was ≤5 years and established SpA if the disease duration was >5 years, while the low BMD was indicated by Z score ≤ −2.00. The correlation was tested using the Spearman or Pearson test. The differences in patients’ characteristics among early and established SpA and also between low and normal BMD were tested using the unpaired T-test or the Mann–Whitney test. The serum DKK-1 levels in early SpA (7365 ± 2067 pg/dL) were significantly higher than those in established SpA (5360 ± 1054 pg/dL). Serum DKK-1 levels were also associated with disease duration (r = −0.370, p = 0.040 ) and BMD at the total hip (r = 0.467, p = 0.028 ). The differences in all patients’ clinical parameters were not found between patients with low BMD at any site and patients with normal BMD unless in the BMI ( p = 0.019 ). Our findings found DKK-1 as a potential diagnostic marker for early SpA. Early diagnosis may lead to rapid treatment to delay disease progression and prevent future impairment.

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Section: Introductionmentioning

confidence: 99%

The Increasing Level of DKK-1 as a New Bone Formation Factor in Patients with Early Spondyloarthritis

Yuliasih,

Permatasari,

Rahmawati

et al. 2023

Autoimmune Diseases

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Clinical and Demographic Profiling of Patients with Spondyloarthritis and Its Association with Disease Activity in a Tertiary Hospital in Surabaya, Indonesia

Yudha,

Rahmawati,

Indrasari

et al. 2024

CIMRJ

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Introduction: The assessment of disease activity is crucial for effectively managing chronic diseases like spondyloarthritis (SpA). Establishing the relationship between disease activity, demographic, and clinical factors is essential for better disease management. This study aimed to delve into the demographic and clinical characteristics of patients at Dr. Soetomo General Academic Hospital, a tertiary hospital in Surabaya, Indonesia, contributing to a comprehensive understanding of SpA occurrences in Surabaya.Methods: Data were obtained from 38 SpA patients’ data classified using ASAS 2009 criteria at Dr. Soetomo General Academic Hospital, excluding individuals with SLE, gout, RA, and septic arthritis. Disease activity was measured using ASDAS-CRP. Association analysis between disease activity, clinical parameters, and demographics was conducted using Mann-Withney U test and Spearman correlation test.Results: Results indicated a male-to-female ratio of 8:30, with patients having a median age of 48 (95% CI: 41-53) and most of the patients had a senior high school education (42.11%). The patients exhibited a mean BMI of 25.19 ± 3.77, a median disease duration of 8.5 (95% CI: 5-10) years, and a median CRP value of 0.2 (95% CI: 0.1-0.5) mg/dL. The majority displayed moderate disease activity, with a median ASDAS-CRP score of 2 (95% CI: 1.5-2.7). Interestingly, no significant correlation was found between disease activity using ASDAS-CRP and the demographic or clinical parameters studied.Conclusion: Disease activities were found not to have correlations with the demography and clinical parameters of patients with SpA from Dr. Soetomo General Academic Hospital in Surabaya, Indonesia. This emphasizes the necessity for further research to comprehend the intricate relationship between disease activity and diverse influencing factors.

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HLA class I and discoveries of the HLA-K (pseudogene) related to disease severity and progression in patients with spondyloarthritis in Dr. Soetomo General Hospital, a tertiary health care center in Surabaya, Indonesia

Cited by 2 publications

References 36 publications

The Increasing Level of DKK-1 as a New Bone Formation Factor in Patients with Early Spondyloarthritis

The Increasing Level of DKK-1 as a New Bone Formation Factor in Patients with Early Spondyloarthritis

Clinical and Demographic Profiling of Patients with Spondyloarthritis and Its Association with Disease Activity in a Tertiary Hospital in Surabaya, Indonesia

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