HLA class II alleles and autoantibodies in Bulgarians with systemic lupus erythematosus

Marintchev, L. M.; Naumova, E.; Rashkov, Rasho; Arnett, Frank C.; Reveille, John D.

doi:10.1111/j.1399-0039.1995.tb03141.x

Cited by 9 publications

(10 citation statements)

References 15 publications

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“…A similar stratified comparison of HLA alleles in all 3 ethnic groups with SLE and anti-P against race-matched normal controls showed strong correlations of anti-P with all of the alleles on these HLA-DR2 haplotypes (DRB1*1501/ (Table 3), although the highest OR was conferred by the HLA-DQB1*0602 allele. Among 3 Greek SLE patients and 1 Bulgarian SLE patient with anti-P, none had HLA-DRB1*1501 or a1503 haplotypes, although 3 had other HLA-DR2 haplotypes common to those populations, i.e., HLA-DRB1*1601 or DRB1*1602, which are in linkage disequilibrium with an HLA-DQ5 haplotype (DQA1*0102, DQB1*0502) (17,18). Among the 5 anti-P-positive Chinese-Americans, 2 had HLA-DRB1*1501, DQA1*0102, DQB1*0602 haplotypes and another had the DR2 (DRB1*1502, DQA1*0103, DQB1*0601) haplotype.…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, these same HLA-DR2 haplotypes have been associated with predisposition to SLE itself in several studies of American and Western European whites (28)(29)(30)(31)(32), blacks (27,33), Chinese (34), Koreans (39, and Japanese (36), but not in Mexican-Americans (37), Greeks (17), or Bulgarians (18). In fact, the HLA-DRB1*1501 haplotype is common in whites of Western European descent, and HLA-DRB1*1503 predominates in blacks (27), while both are less frequent in Mexican-Americans (37), Chinese (34), Koreans (35), and Japanese (36), and even rare in Eastern Europeans, whereas other HLA-DR2 haplotypes occur in higher frequencies and are typically in linkage disequilibrium with HLA-DQ5 alleles (17,18).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the HLA-DRB1*1501 haplotype is common in whites of Western European descent, and HLA-DRB1*1503 predominates in blacks (27), while both are less frequent in Mexican-Americans (37), Chinese (34), Koreans (35), and Japanese (36), and even rare in Eastern Europeans, whereas other HLA-DR2 haplotypes occur in higher frequencies and are typically in linkage disequilibrium with HLA-DQ5 alleles (17,18).…”

Section: Discussionmentioning

confidence: 99%

“…Normal control HLA frequencies were determined previously in Houston using sera from local, unrelated white, black, and Mexican-American volunteers who were medical center personnel or blood bank donors. Normal Greek and Bulgarian control sera were similarly obtained as described in previous studies (17,18). HLA frequencies for normal control sera from Chinese Americans were not available.…”

Section: Methodsmentioning

confidence: 99%

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Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations

Arnett

Reveille

Moutsopoulos

et al. 1996

Arthritis & Rheumatism

142

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Objective. To determine the frequencies and clinical associations of antiribosomal P antibodies (anti-P) in a large multiethnic cohort of patients with systemic lupus erythematosus (SLE), and to assess whether anti-P was associated with any major histocompatibility complex (MHC) class I1 alleles or shared amino acid sequences.Methods. Sera from 394 SLE patients were studied for anti-P using an enzyme-linked immunosorbent assay, and MHC class I1 alleles (HLA-DRB1, DQA1, and DQBl) were determined by DNA oligotyping.Results. Anti-P antibodies were found in 13-2W of patients in the majority of ethnic groups, but were perhaps more frequent in Chinese patients (36%) and less common in Bulgarian patients (6%). Neuropsychiatric lupus (psychosis and/or depression) was significantly associated with anti-P. The HLA-DR2, DQ6 haplotypes DRB1*1501 or *1503, DQA1*0102, and DQB1*0602 were increased in anti-P-positive whites, blacks, and Mexican Americans. The HLA-DQB1*0602 allele showed the strongest association with anti-P when these 3 ethnic groups were combined and compared with both race-matched anti-P-negative SLE patients and normal controls. The HLA-DQS specificity (DQB1*0302) was increased both in whites and in Mexican-Americans with anti-P who were negative for HLA-DQB1*0602, and perhaps also increased in Greeks, but not in blacks, in whom HLA-DQB1*0301 was increased. A shared amino acid sequence in HLADQBl (at position 26 of leucine and position 30 of tyrosine) was strongly associated with anti-P positivity (70%) versus anti-P negativity (42%) across ethnic lines.Conclusion. The anti-P response in SLE patients, occurring in -15% of patients, was strongly influenced by certain MHC class I1 alleles and was correlated with diffuse neuropsychiatric dysfunction.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations

Arnett

Reveille

Moutsopoulos

et al. 1996

Arthritis & Rheumatism

142

View full text Add to dashboard Cite

show abstract

“…However, not all Caucasians followed this path. Some were found to bear DR‐7, for example, 5 while others did not express either DR‐2 or DR‐3 6 . The HLA–DR‐2 or its split, predominantly DR‐15, were more common in some Caucasians, 1 Asians, 7 African Americans 8 and South African Black patients 9 …”

Section: Frequency Of Hla‐dr In Patients With Sle and In Healthy Conmentioning

confidence: 99%

Preliminary report on class II histocompatibility (HLA-DR and DQ) antigens in a subpopulation of Arab patients with systemic lupus erythematosus

Attia

Mahmud

2011

International Journal of Rheumatic Diseases

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Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

Goldstein

et al. 1996

Arthritis & Rheumatism

169

134

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Objective. To determine the frequency, clinical associations, and any major histocompatibility complex correlations of antifibrillarin antibodies in patients with systemic sclerosis (SSc).Methods. Antifibrillarin antibodies were determined by indirect immunofluorescence, immunoblotting, and immunoprecipitation, and HLA class I1 alleles by DNA oligotyping, in a large cohort of SSc patients.Results. Antifibrillarin was found in 8% of 335 SSc sera and was significantly more common in blacks (16%) than whites (S%), in males (33%) than females (14%), and in patients with cardiac, renal, or gut involvement. The HLA class I1 haplotype DRBZ *Z302, DQBZ*0604 was found significantly more frequently in SSc patients with antifibrillarin compared with racematched normal controls and 260 SSc patients without antifibrillarin. In addition, 1 or more of the HLA-DQB1

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HLA class II alleles and autoantibodies in Bulgarians with systemic lupus erythematosus

Cited by 9 publications

References 15 publications

Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations

Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations

Preliminary report on class II histocompatibility (HLA-DR and DQ) antigens in a subpopulation of Arab patients with systemic lupus erythematosus

Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

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