HLA‐class II alleles and C4 null genes in Greeks with systemic lupus erythematosus

Reveille, John D.; Arnett, Frank C.; Olsen, Mary L.; Moulds, Joann M.; Papasteriades, C.; Moutsopoulos, H. M.

doi:10.1111/j.1399-0039.1995.tb03140.x

Cited by 16 publications

(8 citation statements)

References 29 publications

(22 reference statements)

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“…Several publications reveal differences in the genetic profile of Greek patients with autoimmune diseases [9–11]. Boki et al in their study of 66 Greek patients with necrotizing vasculitis did not find any significant associations of HLA-class I and II alleles with PAN and CSS.…”

Section: Discussionmentioning

confidence: 98%

Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients

Tsiveriotis

Tsirogianni²,

Pipi³

et al. 2011

Autoimmune Diseases

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Objective. To retrospectively evaluate ANCA testing in a cohort of unselected Greek in- and outpatients. Methods. In 10803 consecutive serum samples, ANCA were tested by indirect immunofluorescence (IIF) and ELISA. ELISA in inpatients was performed only on IIF positive sera. Results. Low prevalence (6.0%) of IIF positive samples was observed. Among these samples, 63.5% presented perinuclear (p-ANCA), 9.3% cytoplasmic (c-ANCA) and 27.2% atypical (x-ANCA) pattern. 16.1% of p-ANCA were antimyeloperoxidase (anti-MPO) positive, whereas 68.3% of c-ANCA were antiproteinase-3 (anti-PR3) positive. Only 17 IIF negative outpatients' samples were ELISA positive. ANCA-associated vasculitides (AAV), connective tissue disorders and gastrointestinal disorders represented 20.5%, 23.9%, and 21.2% of positive results, respectively. AAV patients exhibited higher rates of MPO/PR3 specificity compared to non-AAV (93.8% versus 8%). Conclusions. This first paper on Greek patients supports that screening for ANCA by IIF and confirming positive results by ELISA minimize laboratory charges without sacrificing diagnostic accuracy.

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Section: Discussionmentioning

confidence: 98%

Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients

Tsiveriotis

Tsirogianni²,

Pipi³

et al. 2011

Autoimmune Diseases

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“…In fact, the HLA-DRB1*1501 haplotype is common in whites of Western European descent, and HLA-DRB1*1503 predominates in blacks (27), while both are less frequent in Mexican-Americans (37), Chinese (34), Koreans (35), and Japanese (36), and even rare in Eastern Europeans, whereas other HLA-DR2 haplotypes occur in higher frequencies and are typically in linkage disequilibrium with HLA-DQ5 alleles (17,18).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, these same HLA-DR2 haplotypes have been associated with predisposition to SLE itself in several studies of American and Western European whites (28)(29)(30)(31)(32), blacks (27,33), Chinese (34), Koreans (39, and Japanese (36), but not in Mexican-Americans (37), Greeks (17), or Bulgarians (18). In fact, the HLA-DRB1*1501 haplotype is common in whites of Western European descent, and HLA-DRB1*1503 predominates in blacks (27), while both are less frequent in Mexican-Americans (37), Chinese (34), Koreans (35), and Japanese (36), and even rare in Eastern Europeans, whereas other HLA-DR2 haplotypes occur in higher frequencies and are typically in linkage disequilibrium with HLA-DQ5 alleles (17,18).…”

Section: Discussionmentioning

confidence: 99%

“…Normal control HLA frequencies were determined previously in Houston using sera from local, unrelated white, black, and Mexican-American volunteers who were medical center personnel or blood bank donors. Normal Greek and Bulgarian control sera were similarly obtained as described in previous studies (17,18). HLA frequencies for normal control sera from Chinese Americans were not available.…”

Section: Methodsmentioning

confidence: 99%

“…A similar stratified comparison of HLA alleles in all 3 ethnic groups with SLE and anti-P against race-matched normal controls showed strong correlations of anti-P with all of the alleles on these HLA-DR2 haplotypes (DRB1*1501/ (Table 3), although the highest OR was conferred by the HLA-DQB1*0602 allele. Among 3 Greek SLE patients and 1 Bulgarian SLE patient with anti-P, none had HLA-DRB1*1501 or a1503 haplotypes, although 3 had other HLA-DR2 haplotypes common to those populations, i.e., HLA-DRB1*1601 or DRB1*1602, which are in linkage disequilibrium with an HLA-DQ5 haplotype (DQA1*0102, DQB1*0502) (17,18). Among the 5 anti-P-positive Chinese-Americans, 2 had HLA-DRB1*1501, DQA1*0102, DQB1*0602 haplotypes and another had the DR2 (DRB1*1502, DQA1*0103, DQB1*0601) haplotype.…”

Section: Frequencies Of Anti-p Antibodies In Different Ethnic Groupsmentioning

confidence: 99%

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Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations

Arnett

Reveille

Moutsopoulos

et al. 1996

Arthritis & Rheumatism

142

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Objective. To determine the frequencies and clinical associations of antiribosomal P antibodies (anti-P) in a large multiethnic cohort of patients with systemic lupus erythematosus (SLE), and to assess whether anti-P was associated with any major histocompatibility complex (MHC) class I1 alleles or shared amino acid sequences.Methods. Sera from 394 SLE patients were studied for anti-P using an enzyme-linked immunosorbent assay, and MHC class I1 alleles (HLA-DRB1, DQA1, and DQBl) were determined by DNA oligotyping.Results. Anti-P antibodies were found in 13-2W of patients in the majority of ethnic groups, but were perhaps more frequent in Chinese patients (36%) and less common in Bulgarian patients (6%). Neuropsychiatric lupus (psychosis and/or depression) was significantly associated with anti-P. The HLA-DR2, DQ6 haplotypes DRB1*1501 or *1503, DQA1*0102, and DQB1*0602 were increased in anti-P-positive whites, blacks, and Mexican Americans. The HLA-DQB1*0602 allele showed the strongest association with anti-P when these 3 ethnic groups were combined and compared with both race-matched anti-P-negative SLE patients and normal controls. The HLA-DQS specificity (DQB1*0302) was increased both in whites and in Mexican-Americans with anti-P who were negative for HLA-DQB1*0602, and perhaps also increased in Greeks, but not in blacks, in whom HLA-DQB1*0301 was increased. A shared amino acid sequence in HLADQBl (at position 26 of leucine and position 30 of tyrosine) was strongly associated with anti-P positivity (70%) versus anti-P negativity (42%) across ethnic lines.Conclusion. The anti-P response in SLE patients, occurring in -15% of patients, was strongly influenced by certain MHC class I1 alleles and was correlated with diffuse neuropsychiatric dysfunction.

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Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

Goldstein

et al. 1996

Arthritis & Rheumatism

169

134

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Objective. To determine the frequency, clinical associations, and any major histocompatibility complex correlations of antifibrillarin antibodies in patients with systemic sclerosis (SSc).Methods. Antifibrillarin antibodies were determined by indirect immunofluorescence, immunoblotting, and immunoprecipitation, and HLA class I1 alleles by DNA oligotyping, in a large cohort of SSc patients.Results. Antifibrillarin was found in 8% of 335 SSc sera and was significantly more common in blacks (16%) than whites (S%), in males (33%) than females (14%), and in patients with cardiac, renal, or gut involvement. The HLA class I1 haplotype DRBZ *Z302, DQBZ*0604 was found significantly more frequently in SSc patients with antifibrillarin compared with racematched normal controls and 260 SSc patients without antifibrillarin. In addition, 1 or more of the HLA-DQB1

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HLA‐class II alleles and C4 null genes in Greeks with systemic lupus erythematosus

Cited by 16 publications

References 29 publications

Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients

Antineutrophil Cytoplasmic Antibodies Testing in a Large Cohort of Unselected Greek Patients

Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations

Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

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