HLA-Class II Alleles in Egyptian Patients with Hepatocellular Carcinoma

El-Chennawi, Farha; Auf, Fatma A; Metwally, Shereen S; Mosaad, Youssef M.; El–Wahab, M. Abd; Tawhid, Ziyad E

doi:10.1080/08820130802111605

Cited by 27 publications

(18 citation statements)

References 40 publications

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“…For analysis, liver fibrosis was also classified either being mild (0-2), moderate (3)(4) or severe (5-6). Activity was graded into minimal (0-4), mild (5-8), moderate (8)(9)(10)(11)(12) and severe (13)(14)(15)(16)(17)(18)). All patients were tested negative for both hepatitis B surface antigen (HBs antigen) and anti-HIV antibody.…”

Section: Methodsmentioning

confidence: 99%

“…Because the prevalence of HCV is exceeding that of hepatitis B virus (HBV) infection, HCV infection has become the leading risk factor for HCC in Egypt (antibodies present in as many as 75-90% of HCC cases) [9,10]. The frequency of liver-related cancers (>95% as HCC) relative to all cancers in Egypt has increased from approximately 4.0% in 1993 to 7.3% in 2003 [11].…”

Section: Introductionmentioning

confidence: 99%

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Association of Human Leucocyte Antigen Class I (HLA-A and HLA-B) With Chronic Hepatitis C Virus Infection in Egyptian Patients

Mosaad

Farag

Arafa

et al. 2010

Scandinavian Journal of Immunology

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Egypt has the highest prevalence of hepatitis C virus (HCV) in the world, ranging from 6% to 28% with an average of approximately 13.8% in the general population. It has been reported that human leucocyte antigen (HLA) alleles are associated with the outcome of HCV infection, but this associations showed ethnic and geographical differences. The objective of this study is to investigate the association between the frequencies of HLA Class I and chronic HCV infection in Egyptian patients and to find out whether there is a relation between certain HLA Class I antigens and HCV viral load, degree of fibrosis, activity and alanine aminotransferase (ALT) level. A case control study was conducted on 100 patients with chronic HCV infection and 150 healthy controls. HLA‐A and HLA‐B typing by complement‐dependent micro‐lympho‐cytotoxicity assay was performed for both groups. HLA‐A11 antigen was significantly increased in patients with chronic HCV infection versus controls (OR 3.98; 95% CI = 1.85–8.89; P = 0.001; and Pc = 0.021). HLA‐B12, HLA‐B13, HLA‐B17 and HLA‐B40 were higher in patients, and HLA‐A32 and HLA‐B14 were higher in controls, although the significance was lost after correction for multiple testing. HLA‐A9 was significantly associated with low viral load (P = 0.008, Pc = 0.048). The results of this work implicate that HLA‐A11 antigen may influence chronic HCV infection and may play a role in viral persistence. Different HLA Class I antigens are not associated with degree of liver fibrosis, grades of activity or level of ALT. However, HLA‐A9 is associated with low HCV viral load in chronic HCV Egyptian patients.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Human Leucocyte Antigen Class I (HLA-A and HLA-B) With Chronic Hepatitis C Virus Infection in Egyptian Patients

Mosaad

Farag

Arafa

et al. 2010

Scandinavian Journal of Immunology

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“…A high a significant difference between DQB1*02 and metavir score(F and A) was observed for that a lot of study associated between DQB1*02 with Hepatocellular Carcinoma as El-Chennawi et al (2008) concluded that the DRB1*04 and DQB1*02 alleles might be risk factors for the occurrence of HCC also found DQB1*02 to be associated with disease persistence even after IFN. The present study also investigated the effect of Interleukin (IL)-10 level on response to treatment and its relation with disease state.…”

Section: Discussionmentioning

confidence: 97%

Factors Affecting the Response to Interferon Alpha Therapy in Egyptian HCV Patients

Alhusseini

Serry²,

Kadry³

et al. 2015

American Journal of Immunology

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“…El-Chennawi et al 12 studied the association of hla class ii DRB1 and DQB1 polymorphisms with hcc in Egyptian patients and investigated the role of those polymorphisms as risk factors for the development of hcc. Those authors found a significantly increased frequency of DRB1*04 and DQB1*02 (p = 0.016 and 0.032 respectively) and a significantly decreased frequency of DQB1*06 (p = 0.032) in their hcc patients compared with a control group.…”

Section: Discussionmentioning

confidence: 99%

“…To date, many genetic factors have been reported to be related to a susceptibility to hcc: polymorphisms of tumour necrosis factor α 6,7 , of epidermal growth factor and epidermal growth factor receptor 8,9 , of the transforming growth factor β1 gene 10 , and of major histocompatibility complex (mhc) or human leucocyte antigen (hla) [11][12][13][14][15] , among others. Of the foregoing genetic factors, mhc plays a key role in antivirus activity and tumour defense.…”

Section: Introductionmentioning

confidence: 99%

Relationship between HLA-DRB1 Allele Polymorphisms and Familial Aggregations of Hepatocellular Carcinoma

Wei

et al. 2016

Current Oncology

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Objective We explored the relationship between HLA-DRB1 allele polymorphisms and familial aggregation of hepatocellular carcinoma (fhcc).Methods Polymerase chain reaction sequence-specific primers were used to determine HLA-DRB1 genotypes for 130 members of families with 2 or more liver cancer patients and for 130 members of families without any diagnosed cancers. The genotype profiles were then compared to explore the relationship between HLA-DRB1 gene polymorphism and fhcc.Result Of 11 selected alleles, the frequencies of DRB1*11 and DRB1*12 were significantly lower in the fhcc group than in no-cancer group (p < 0.05; odds ratio: 0.286; 95% confidence interval: 0.091 to 0.901; and odds ratio: 0.493; 95% confidence interval: 0.292 to 0.893). Differences in the frequencies of the other 9 alleles were not statistically significant in the two groups (p > 0.05). ConclusionsOur research suggests that if genetic factors play a role in fhcc, the deficiency in the DRB1*11 and DRB1*12 alleles might be the risk factor at work in Guangxi Zhuang Autonomous Region, P.R.C.

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HLA-Class II Alleles in Egyptian Patients with Hepatocellular Carcinoma

Cited by 27 publications

References 40 publications

Association of Human Leucocyte Antigen Class I (HLA-A and HLA-B) With Chronic Hepatitis C Virus Infection in Egyptian Patients

Association of Human Leucocyte Antigen Class I (HLA-A and HLA-B) With Chronic Hepatitis C Virus Infection in Egyptian Patients

Factors Affecting the Response to Interferon Alpha Therapy in Egyptian HCV Patients

Relationship between HLA-DRB1 Allele Polymorphisms and Familial Aggregations of Hepatocellular Carcinoma

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