HLA Class II Associations in African-American Female Patients with Graves' Disease

Yanagawa, Tatsuo; DeGroot, Leslie J.

doi:10.1089/thy.1996.6.37

Cited by 15 publications

(10 citation statements)

References 17 publications

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“…We observed that the frequency of any DQB1 allele including DQB1*0301 was not significantly increased in this study, whereas DQB1*0302 was nonsignificantly decreased. However, DR3 was not found to be associated with Graves' disease in African American patients, as reported in previous studies (7,8,17), nor in our current study reported here. DR3 has been associated with Graves' disease in Caucasians (1), as well as in African Blacks of Zulu descent (16).…”

Section: Discussionsupporting

confidence: 81%

“…The frequency of DQA1*0501 was increased significantly in the patients with adult onset of Graves' disease reported here, but this was not the case for a group of African American patients with Graves' disease reported in another study (8). It is noted that the frequency of DQA1*0501 in African American control subjects varies, dependent on their residing areas (8,22).…”

Section: Discussioncontrasting

confidence: 74%

“…In two recent studies, one group found DQ3 to be associated with Graves' disease (7), whereas another group found no significant associations between Graves' disease and the HLA class II genes they tested, which included the major alleles of the DRB1, DQA1, and DQB1 loci (8). In two recent studies, one group found DQ3 to be associated with Graves' disease (7), whereas another group found no significant associations between Graves' disease and the HLA class II genes they tested, which included the major alleles of the DRB1, DQA1, and DQB1 loci (8).…”

mentioning

confidence: 98%

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The Human Leukocyte Antigen HLA DRB3∗0202/DQA1∗0501 Haplotype Is Associated with Graves’ Disease in African Americans

Chen¹,

Nadell²,

Zhang³

et al. 2000

The Journal of Clinical Endocrinology & Metabolism

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Information on genetic susceptibility to Graves' disease in African Americans is limited. We studied DRB1, DQB1, DRB3 subtypes, DQA1*0501, DQA1*0201, and CTLA-4 polymorphisms in 49 African American patients with adult onset Graves' disease and 47 racially-matched controls using PCR-based sequence-specific priming methods. There were no significant differences in DRB1 or DQB1 allelic frequencies or CTLA-4 polymorphisms between patients and controls. However, we found that the frequency of DRB3 was significantly increased in the patients (75.5% vs. 57.4%, P = 0.006, X2 = 3.52), especially for the DRB3*0202 subtype (53.1% vs. 23.4, P = 0.003, X2 = 8.91). In this one respect, the finding was in concordance with our previous observations in Caucasian patients with adult-onset Graves' disease. In addition, whereas the frequency of DQA1*0501 was increased (P = 0.018, X2 = 5.63) in our patients, the haplotype of DRB3/DQA1*0501, or DRB3*0202/DQA1*0501 was found to be more strongly associated (P = 0.008, X2 = 7.0; P = 0.0008, X2 = 11.34, respectively). These data suggest that DRB3*0202, particularly when found with DQA1*0501 in a haplotype is a susceptible gene(s) for Graves' disease in adult African Americans. Considering these data with those in Caucasian patients, our results would suggest that the primary Graves susceptible locus is likely DRB3 and not DRB1.

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 74%

mentioning

confidence: 98%

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The Human Leukocyte Antigen HLA DRB3∗0202/DQA1∗0501 Haplotype Is Associated with Graves’ Disease in African Americans

Chen¹,

Nadell²,

Zhang³

et al. 2000

The Journal of Clinical Endocrinology & Metabolism

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“…Indeed DQA1*05 has been associated with GD in Latvians and Brazilians (Marga et al 2001;Maciel et al 2001). However, it was not found to be associated with GD in the Greek population (Philippou et al 2001) or in African-American patients (Yanagawa and De Groot 1996;Ofosu et al 1996). In our study, no association was found between DQA1*05 and GD patients ( Table 1 in the "Appendix").…”

Section: Discussioncontrasting

confidence: 68%

Genetics of autoimmune thyroid disease in the Lebanese population

et al. 2012

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This study aims to investigate the association of human leukocyte antigen (HLA) class II genes and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) with autoimmune thyroid diseases in the Lebanese population. A total of 128 patients with autoimmune thyroid disease (55 with Graves' disease (GD) and 73 with Hashimoto's thyroiditis (HT)) were typed for HLA DQA1 (0301 and 0501) and DQB1 (0201, 0302, and 0303) and for 49A/G CTLA-4 using PCR-based sequence-specific priming methods. A total of 186 matched controls were typed for the same alleles and compared to the diseased population. Results showed no significant differences in HLA DQB1*0201 or DQB1*0301 allelic frequencies or CTLA-4 polymorphisms between patients and controls. For GD, there was a weak association with HLA DQB1*0302 [34.6% (19 of 55)

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“…Whether there are associations between GD and the HLA complex among African-Americans is questioned. An association between GD and HLA-DQ3 has been reported (56), whereas in other studies, there were no significant differences in HLA distribution between patients and controls (57,58). Such an inconsistency is also observed among different Caucasian populations, ie, the relative risk asso- "Only DR3 maintained a statistically significant association when assessed in a logistic model.…”

Section: Hla Markers and Gdmentioning

confidence: 92%

What is the Evidence of Genetic Factors in the Etiology of Graves' Disease? A Brief Review

Brix¹,

Kyvik²,

Hegedűs³

1998

Thyroid

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Graves' disease (GD) is generally thought of as a multifactorial disorder in which genetic susceptibility interacts with environmental and endogenous factors to cause disease. The importance of genetic factors is suggested by the clustering of GD within families and by a higher concordance rate for disease in monozygotic than in dizygotic twins. This has, however, recently been shown to be less pronounced than previously thought. During the last decade much effort has been put into characterization of the genetic background of GD. Until recently, most studies have examined associations between GD and the human leukocyte antigen (HLA) region, but recent advances in molecular techniques have opened the way for whole genome screening. A number of HLA and non-HLA candidate genes have been proposed, but despite several large investigations within multiplex families no major susceptibility genes have been identified. This brief review discusses relevant articles published from 1940 through 1997 regarding the influence of genetic factors in the etiology of GD. Ongoing studies focus on whole genome screening in multiplex families as well as population-based twin studies. However, the possibility of GD being a heterogeneous disease without a single well-defined genotype and phenotype should be left open.

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HLA Class II Associations in African-American Female Patients with Graves' Disease

Cited by 15 publications

References 17 publications

The Human Leukocyte Antigen HLA DRB3∗0202/DQA1∗0501 Haplotype Is Associated with Graves’ Disease in African Americans

The Human Leukocyte Antigen HLA DRB3∗0202/DQA1∗0501 Haplotype Is Associated with Graves’ Disease in African Americans

Genetics of autoimmune thyroid disease in the Lebanese population

What is the Evidence of Genetic Factors in the Etiology of Graves' Disease? A Brief Review

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