HLA class II polymorphism in Thai patients with non‐Hodgkin’s lymphoma

Nathalang, Oytip; Tatsumi, Noriyuki; Hino, Masayuki; Prayoonwiwat, Wichai; Yamane, Takahisa; Suwanasophon, Chamaiporn; Sriphaisal, Thip

doi:10.1046/j.1365-2370.1999.00177.x

Cited by 13 publications

(9 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DRB1*09 allele in our data is in agreement with significant increase of the DRB1*09 allele in the data from Thai patients with NHL [15]. However, our data is different from the study on Egyptian children patients with NHL, the HLA-DRB1*0403 and DRB1*1301 alleles, and the HLA-DQB1*0501, HLA-DQB1*0201, and HLA-DQB1*0301 alleles were significantly increased while the HLA-DRB1*1302, DQB1*0502, and DQB1*0602 alleles were significantly decreased [16].…”

Section: Discussionsupporting

confidence: 91%

Association of HLA alleles with non-Hodgkin’s lymphoma in Korean population

et al. 2008

View full text Add to dashboard Cite

Several studies have been performed on the association between non-Hodgkin's lymphoma (NHL) and the presence of certain human leukocyte antigens (HLA) class II alleles in Asian countries, and these studies have shown different results, according to the ethnicity, for the frequencies of the HLA class II alleles, and especially for HLA-DRB1. Therefore, the distribution of the HLA-A, B, C, DRB1, and DQB1 alleles in 89 Korean patients with NHL and also in 200 healthy Korean controls was investigated in this study. For the class I alleles, the frequencies of HLA-B51 was increased in patients with NHL and diffuse large B cell (DLBC) lymphoma compared with the normal control. For the class II alleles, the frequencies of the HLA-DRB1*09 and DQB1*03 alleles were increased in patients with NHL and DLBC lymphoma compared with the normal controls. Also, the B51-DRB1*09-DQB1*03 haplotype was significantly increased in the patients with NHL. These results suggest that some genes in HLA-B*51-DRB1*09-DQB1*03 haplotype may contribute to NHL susceptibility in the Korean population.

show abstract

Section: Discussionsupporting

confidence: 91%

Association of HLA alleles with non-Hodgkin’s lymphoma in Korean population

et al. 2008

View full text Add to dashboard Cite

show abstract

“…[12][13][14][15][16] However, this feature has not been extensively studied specifically in DLBCL, although some data suggest an association between HLA subtypes and disease susceptibility (ie, a higher incidence of HLA-DRB1*04:01 allele in this lymphoma subgroup). Moreover, previous studies including survival analyses were limited and performed before the rituximab era, and therefore their conclusions cannot be applied to the current standard of care.…”

Section: Discussionmentioning

confidence: 99%

“…[9][10][11] However, there is little information about the relationship between HLA polymorphisms and susceptibility to developing B-NHL or their outcomes. [12][13][14][15][16] Focusing on diffuse large B-cell lymphoma (DLBCL), some associations between HLA specificities and this B-NHL subtype have been described, as well as with other genetic polymorphisms. Shorter progression-free survival (PFS) and overall survival (OS) have been observed in DLBCL patients lacking the HLA-DR2 or carrying TNF -308A.…”

Section: Introductionmentioning

confidence: 99%

HLA specificities are related to development and prognosis of diffuse large B-cell lymphoma

Alcoceba

Sebastián

Marı́n

et al. 2013

Blood

View full text Add to dashboard Cite

Key Points• DLBCL patients carrying the HLA-B44 supertype have a worse progression-free and overall survival after R-CHOP-like treatment.• The HLA-DRB1*01 allele increases the risk of DLBCL development.Diffuse large B-cell lymphoma (DLBCL) is an aggressive disease influenced by genetic and environmental factors. The role of the HLA system in tumor antigen presentation could be involved in susceptibility and disease control. We analyzed the phenotypic frequencies of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 in 250 DLBCLs, comparing them with 1940 healthy individuals. We also evaluated the influence of HLA polymorphisms on survival in those patients treated with curative intention using cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP)-like regimen without (n 5 64, 26%) or with (n 5 153, 61%) rituximab. DLBCL patients have a higher phenotypic frequency of HLA-DRB1*01 (29% vs 19.5%, P 5 .0008, Pc 5 .0104) and a lower frequency of HLA-C*03 (6.4% vs 17.9%, P < .0005, Pc 5 .007) compared with healthy individuals. Irrespective of the age-adjusted International Prognostic Index, those patients receiving a CHOP-like plus rituximab regimen and carrying the HLA-B44 supertype had worse 5-year progression-free (54% vs 71%, P 5 .019) and 5-year overall (71% vs 92%, P 5 .001) survival compared with patients without this supertype. Our data suggest that some HLA polymorphisms influence the development and outcome of DLBCL, allowing the identification of an extremely good-risk prognostic subgroup. However, these results are preliminary and need to be validated in order to exclude a possible population effect. (Blood. 2013;122(8):1448-1454 IntroductionSeveral genetic polymorphisms have been associated with susceptibility or prognosis in various B-cell non-Hodgkin lymphoma (B-NHL) subtypes.1,2 In recent years, genome-wide association studies have identified 6p21.3 as a risk region for susceptibility of different lymphomas, such as follicular lymphoma [3][4][5] or Hodgkin lymphoma. 6,7 The HLA system, located in this region, plays a key role in antitumor immune responses and lymphoma-cell apoptosis 8 and so may be essential for neoplasia control. Previous studies have shown a relationship between HLA polymorphisms and susceptibility to certain hematologic malignancies such as chronic lymphocytic leukemia, multiple myeloma, and acute lymphoblastic leukemia.9-11 However, there is little information about the relationship between HLA polymorphisms and susceptibility to developing B-NHL or their outcomes.12-16 Focusing on diffuse large B-cell lymphoma (DLBCL), some associations between HLA specificities and this B-NHL subtype have been described, as well as with other genetic polymorphisms. Shorter progression-free survival (PFS) and overall survival (OS) have been observed in DLBCL patients lacking the HLA-DR2 or carrying TNF -308A.13 In addition, OS is shorter in those patients carrying the C*07-B*08-LTA1 252G -TNF -308A haplotype 14 or the HLA-C*07:01. 16 However, these studies considered patients treated before...

show abstract

“…As a consequence, several immunopathological conditions reveal a restricted MHC expression [Gill, 1996], a process for which highly conserved ancestral haplotype [Price et al, 1999] and the peptide-binding regions of the MHC molecules may have the highest relevance [Hughes et al, 1996]. However, an MHC-related genetic susceptibility has not only been found in diseases that clearly involve immune defense mechanisms, such as allograft rejections [Benichou, 1999;Klein and Sato, 2000b], infections [Bellamy and Hill, 1998;Klein and Sato, 2000b] and autoimmune disorders [Ridgway and Fathman, 1999;Klein and Sato, 2000b], but there is evidence for an MHC association in cancer [Varanasi et al, 1999], leukemia [Dorak et al, 1999], lymphoma [Nathalang et al, 1999] and even non-autoimmune hereditary [Blum and Miller, 2000], degenerative [Ballo et al, 1996] and ischemic disease [Smith et al, 1983;Mintz et al, 1992;Roach, 1993;Aoyagi et al, 1995]. So far, genes within the HLA complex are the only proven genetic risk factors in idiopathic childhood ischemic stroke [Mintz et al, 1992;Wang et al, 1992;Roach, 1993;Kirkham et al, 2000].…”

Section: Introductionmentioning

confidence: 99%

Evidence for Human Leukocyte Antigen-Related Susceptibility in Idiopathic Childhood Ischemic Stroke

et al. 2002

View full text Add to dashboard Cite

Stroke in children is a relatively uncommon condition and frequently associated with other diseases like cardiopathies, sickle cell disease and chronic smoking. In contrast to stroke in adults, it is rarely caused by atherosclerosis, hypertension or diabetes mellitus. Childhood stroke of unknown causes is called idiopathic stroke. The etiology of idiopathic stroke is unknown. However, several so-called idiopathic diseases develop on the basis of a genetic predisposition. As an approach to investigate this possibility in idiopathic childhood ischemic stroke, we studied the relationship between clinical and immunogenetic features in this disease. We demonstrate that the gene frequencies and relative risk of HLA-B51 were markedly increased in our patients compared with controls (p < 0.001). Thirteen of seventeen HLA-B51-positive patients had had a preceding respiratory infection, which was a higher proportion than in the control group (p < 0.05). In the patient group, the alleles HLA-DRB1*0802, -DRAI*0401 and -DQBI*0402 were also significantly increased, defining the haplotype DRB1*0802-DRA1*0401-DQB1*0402 as a high-risk haplotype for idiopathic childhood ischemic stroke. Transient viral or bacterial infections, which involve vasculitis and vascular occlusion in the brain, can trigger idiopathic childhood ischemic stroke on the basis of an genetic predisposition.

show abstract

HLA class II polymorphism in Thai patients with non‐Hodgkin’s lymphoma

Cited by 13 publications

References 6 publications

Association of HLA alleles with non-Hodgkin’s lymphoma in Korean population

Association of HLA alleles with non-Hodgkin’s lymphoma in Korean population

HLA specificities are related to development and prognosis of diffuse large B-cell lymphoma

Evidence for Human Leukocyte Antigen-Related Susceptibility in Idiopathic Childhood Ischemic Stroke

Contact Info

Product

Resources

About