HLA class II sequence polymorphism and susceptibility to rheumatoid arthritis in greece

Boki, KA; Vaughan, R; Drossos, A.; Moutsopoulos, H M; Gs, Panayi; Lanchbury, Jerry S.

doi:10.1016/0198-8859(91)90262-8

Cited by 9 publications

(20 citation statements)

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“…The relationship of the DRB1*0401 alleles with the predisposition to the disease in our study was in compliance with the studies conducted on Spanish (13), Greek (14) and Caucasian (15) populations, as well as the populations in various regions in Turkey (11,12). Similarly, the relationship of the DRB1*0408 subtype with the predisposition to RA in our study was in line with other studies conducted (15).…”

Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

“…In the Spanish (13) and Greek populations (14), the DRB1*1001 allele was found to be related with the predisposition to RA. In line with our study, RA patients in Greece were also observed to have the DRB1*10 alleles (14). However, no significant relationship between the DRB1*10 alleles and RA was observed in studies conducted in Morocco (18), Kuwait (19) and Pakistan (13).…”

Section: Discussionmentioning

confidence: 99%

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Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

Batmaz¹,

Sarıyıldız²,

Dilek³

et al. 2013

Tftr

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

Batmaz¹,

Sarıyıldız²,

Dilek³

et al. 2013

Tftr

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“…In addition, many clinical and laboratory parameters including age at onset, disease duration [3,5,6,7], total joint count with tenderness and swelling [8,9,10,11], and presence of rheumatoid nodules [3,9,11,12,13,14], systemic manifestations, and radiological changes [3,8,15] may contribute to unfavorable prognosis. Finally, high erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values [7,8,11,14,16,17] and the rheumatoid``shared epitope'' may also in¯uence RA disease severity and outcome [18,19,20].…”

Section: Introductionmentioning

confidence: 99%

Clinical course and outcome of early rheumatoid arthritis

Katsimbri

Katsaraki

et al. 2001

Rheumatology International

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We studied whether patients with seropositivity in early rheumatoid arthritis (RA) comprise a different clinical group than those with seronegativity. Four hundred seventeen patients with early RA according to the American College of Rheumatology criteria (disease duration less than 1 year) were retrospectively studied by analysis of demographic, clinical, laboratory, radiological, and therapeutic disease characteristics from the time of diagnosis until the end of the study period (1981 1999) using a data base. There were 248 seropositive patients and 169 seronegative patients with RA. No statistically significant differences were seen between the two groups before commencement of the study period in relation to age of disease onset, male:female ratio, and disease duration. However, seropositive patients showed longer medical follow-up. In addition, at disease onset, seropositive RA patients presented more frequently with symmetrical polyarthritis and small joint involvement than seronegative patients. The seropositive group also had more tender and swollen joints, weaker grip strength, and higher erythrocyte sedimentation and C-reactive protein rates during the follow-up period. In contrast, the seronegative group had less severe radiological findings and greater functional ability at the end of the study. In Greek patients with early RA, rheumatoid factor seems to be a predictor of more severe disease activity.

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“…The initial MHC studies by Stastny 3 showing an association of RA with HLA-DR4 have subsequently been confirmed in multiple ethnic groups 4 with some exceptions. [5][6][7] Further analyses of these HLA associations have indicated that the majority of RA-associated HLA-DRB1 alleles share a common structural feature at positions 70-74 of the DRB1 chain: Q K R A A (DRB1*0401) or Q R R A A (DRB1*0404, 0405, 0408, 0101, 1402) or R R R A A (DRB1*1001). This finding has given rise to the shared epitope hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis of multiplex rheumatoid arthritis families

et al. 1999

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To examine the genetic contribution of HLA and non-HLA genes in the etiopathogenesis of rheumatoid arthritis (RA), 60 Caucasian multiplex families were identified and DNA analyzed for over 52 markers including DRB1, DQA1 and DQB1 alleles. Many of the markers were chosen because of close proximity to candidate genes suggested by previous studies or models of pathogenesis. Sibling pair analysis (SIBPAL), relative pair analysis (RELPAL) and linkage studies using two different models of inheritance suggested linkage for the MHC and two additional chromosomal regions: chromosome 2 (D2S443 near CD8 and IG ; 2p13-2p11.1), and chromosome 15 (CYP19-estrogen synthase; 15q15). No support was found for two chromosomal regions, 1p36 and 3q13, recently suggested by other studies. We used transmission disequilibrium testing (TDT), conditional logistic regression, and segregation analysis to study the contributions that the shared epitope and TNF-c have in contributing to risk for RA. These studies provide additional evidence that the association of HLA alleles in RA patients from multiplex families is similar to that observed in sporadic disease, suggest candidate regions for further analysis and find additional support for an association of TNF-c alleles with RA susceptibility.

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HLA class II sequence polymorphism and susceptibility to rheumatoid arthritis in greece

Cited by 9 publications

References 0 publications

Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

Clinical course and outcome of early rheumatoid arthritis

Genetic analysis of multiplex rheumatoid arthritis families

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