HLA COMPATIBILITY AND LIVER TRANSPLANT OUTCOME Improved Patient Survival by HLA and Cross-Matching

Nikaein, Afzal; Bäckman, Lars; Jennings, Linda W.; Levy, Marlon F.; Goldstein, Robert M.; Gonwa, T.; Stone, Marvin J.; Klintmalm, Göran B.

doi:10.1097/00007890-199410000-00006

Cited by 31 publications

(36 citation statements)

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“…Moreover, the OPTN data allowed us to consider only a part of the HLA system—that is, HLA A, B (Class I) and DR (Class II). Others have shown a potential effect of other HLA antigens or antibody reactivity in graft survival 13–15. Also, some have shown an effect of HLA G in rejection 13, 16.…”

Section: Discussionmentioning

confidence: 99%

The effect of HLA class I (A and B) and class II (DR) compatibility on liver transplantation outcomes: An analysis of the OPTN database

et al. 2006

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The purpose of this study was to explore the relationship between human leukocyte antigen (HLA) compatibility and liver transplantation outcomes by analyzing the effect of HLA compatibility on 5-year graft survival. We analyzed first liver transplants between 1987 and 2002 in the Organ Procurement and Transplantation Network (OPTN) database, where A, B, or DR loci data were available. Graft failure was defined as retransplantation or death from transplant-related cause. We evaluated associations between total and locus-specific match levels and 5-year graft survival. Multivariable Cox proportionalhazard models were used to evaluate statistical interactions and adjust for the effect of potential confounders. Among 29,675 first-time transplants, the overall degree of HLA match had no effect on 5-year graft survival, even after controlling for potential confounders. Univariate and multivariable analyses showed that the 0 HLA antigen mismatch cohort of patients had higher 5-year graft failure rates than the other 6 antigen mismatch groups. However, this occurred in a small group with a disproportionately large number of live donors and split-liver recipients. When these recipients were excluded from the analysis, the effect was no longer seen. Finally, multivariable, locus-specific analyses showed no association between 5-year graft survival and degree of match/mismatch and the A, B, or DR loci. In conclusion, this careful examination of the OPTN database, with respect to HLA match or mismatch and liver graft survival, reaffirms that HLA matching has no clinically significant impact on this outcome. Liver Transpl 12: 652-658, 2006.

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Section: Discussionmentioning

confidence: 99%

The effect of HLA class I (A and B) and class II (DR) compatibility on liver transplantation outcomes: An analysis of the OPTN database

et al. 2006

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“…Liver allografts are well accepted in the absence of human leukocyte antigen (HLA) matching [1][2][3], and despite the recently suggested involvement of the HLA-C locus in long-and short-term transplant outcome [4,5], its role is still controversial [6]. In addition, other recent studies point to a contribution of natural killer (NK) cells rather than CD8 ϩ T effector cells in early acute rejection [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Divergences in KIR2D+ natural killer and KIR2D+CD8+ T-cell reconstitution following liver transplantation

et al. 2011

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“…Several studies have investigated the possible role of the human leukocyte antigen (HLA) system in liver transplantation, although no beneficial effect of HLA compatibility has been firmly established [1,2]. Moreover, it has been reported that HLA compatibility, in particular partial or total HLA-A and -B class I matching, could have a detrimental effect on liver graft acceptance [3,4].…”

Section: Introductionmentioning

confidence: 99%

Impact of Recipient HLA-C in Liver Transplant: A Protective Effect of HLA-Cw*07 on Acute Rejection

et al. 2007

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HLA COMPATIBILITY AND LIVER TRANSPLANT OUTCOME Improved Patient Survival by HLA and Cross-Matching

Cited by 31 publications

References 0 publications

The effect of HLA class I (A and B) and class II (DR) compatibility on liver transplantation outcomes: An analysis of the OPTN database

The effect of HLA class I (A and B) and class II (DR) compatibility on liver transplantation outcomes: An analysis of the OPTN database

Divergences in KIR2D+ natural killer and KIR2D+CD8+ T-cell reconstitution following liver transplantation

Impact of Recipient HLA-C in Liver Transplant: A Protective Effect of HLA-Cw*07 on Acute Rejection

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