HLA, complement C2, C4, properdin factor B and glyoxalase types in South Indian diabetics

Kirk, R. L.; Ranford, P.R.; Serjeantson, S. W.; Thompson, Arthur R.; Chetty, S.M. Munirathnam; John, Lily; Mohan, Viswanathan; Ramachandran, Ambady; Snehalatha, Chamukuttan; Viswanathan, M

doi:10.1016/s0168-8227(85)80027-9

Cited by 19 publications

(8 citation statements)

References 21 publications

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“…Genes within the human MHC are not thought to be involved in the aetiology of Type 2 diabetes. However, in a previous study of Dravidian subjects [45] although no association of Type 2 diabetes was found with HLA-A, HLA-B, properdin factor B, second component of complement nor glyoxylase, an association was seen of the fourth component of complement (in particular, a decrease of C4B1 and an increase in C4B2). Furthermore, a weak association of HLA-Bw61 with South African Indians has recently been noted [46].…”

Section: Discussionmentioning

confidence: 61%

The genetic predisposition to fibrocalculous pancreatic diabetes

et al. 1989

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Summary. Fibrocalculous pancreatic diabetes (previously known as tropical pancreatic diabetes) is a rare cause of diabetes confined to countries within the tropical belt. The aetiology of fibrocalculous pancreatic diabetes is thought to be environmental although the agent(s) is unknown. We have investigated a possible genetic basis of this disease by looking for restriction fragment length polymorphisms of genes implicated in the aetiology of diabetes rnellitus. Seventy-six Dravidian patients with fibrocalculous pancreatic diabetes were studied, and the restriction fragment length polymorphisms obtained compared to racially matched control subjects (n=94), patients with Type2 (non-insulin-dependent) diabetes (n=87) and Type 1 (insulin-dependent) diabetes (n = 58). No association of fibrocalculous pancreatic diabetes was found with restriction fragment length polymorphisms of the insulin receptor gene. Although no association of fibrocalculous pancreatic diabetes was found with polymorphism of the HLA DRc~/DQc~/DXct genes, an association was found with the Taq 1 restriction fragment length polymorphisms of the DQ[~ gene (DQ[~ T2/T6 present in 39% of patients with fibrocalculous pancreatic diabetes compared to 19% in control subjects; p = 0.01 ; corrected p value = 0.04) which is similar to that found in Type 1 but not Type 2 diabetes. An association of fibrocalculous pancreatic diabetes was also found with the hypervariable region in the 5-prime flanking region of the insulin gene; 40% of patients possessed the class 3 allele compared to 9.5% of control subjects p = 0.0001 ; corrected p value = 0.0008). In Type 2 diabetes, similar results were obtained with 33% subjects possessing the class 3 allele (t7 value compared to control subjects = 0.0005; corrected p value = 0.004). This study suggests that fibrocalculous pancreatic diabetes has a genetic component in its aetiology. Furthermore, its origin might be related to an individual with part of the genetic predisposition to diabetes (Type 1 or Type 2) who additionally has evidence of chronic calcific pancreatitis.

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Section: Discussionmentioning

confidence: 61%

The genetic predisposition to fibrocalculous pancreatic diabetes

et al. 1989

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“…A GLO1 allele frequency in insulin-dependent diabetes higher than in non-diabetic patients was reported by Cambdonde Mouzon et al (1982). Other studies have not found changes in GLO 1-1 phenotype or GLO' allele frequency in insulindependent diabetic patients (Tokanaga et al, 1982;Kirk et al, 1985). For non-insulin-dependent diabetic patients, Kirk et al (1979) found an excess of GLO 2-2 phenotype and a deficiency of GLO 1-2 phenotype whereas other surveys (Kirk et al, 1985;McCann et al, 1981) produced no significant difference.…”

Section: Biological Effects Of Methylglyoxalmentioning

confidence: 90%

“…Other studies have not found changes in GLO 1-1 phenotype or GLO' allele frequency in insulindependent diabetic patients (Tokanaga et al, 1982;Kirk et al, 1985). For non-insulin-dependent diabetic patients, Kirk et al (1979) found an excess of GLO 2-2 phenotype and a deficiency of GLO 1-2 phenotype whereas other surveys (Kirk et al, 1985;McCann et al, 1981) produced no significant difference. However, more interestingly, insulin-dependent diabetic patients without clinical complications had a significant excess of the homozygote GLO 1-1 whereas patients with complications did not (McCann et al, 1981).…”

Section: Biological Effects Of Methylglyoxalmentioning

confidence: 90%

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

Thornalley

1990

Biochemical Journal

732

502

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“…Previous investigations of the South Indian population have been useful in studying the involvement of other HLA genes in IDDM susceptibility (3,4). Patterns of linkage disequilibrium in South Indians are different from those found in White Australians and t h i s allowed at least one IDDM susceptibility allele to be localized to the HLA-DQB gene (4).…”

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confidence: 99%

HLA‐DP, ‐DQ and ‐DR RFLP types in South Indian insulin‐dependent diabetes mellitus patients

1990

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The frequencies of HLA-DP, DQ and DR RFLP types are compared between insulin-dependent diabetes mellitus (IDDM) patients and healthy controls in the South Indian population. There are no significant differences in the frequencies of any of the DPA. DPB haplotypes, when allowance is made for multiple comparisons. The individual frequencies of two novel alleles, designated "DPA*B" and "DPB*B", however, are significantly higher in controls than in patients, suggesting that these alleles are protective against IDDM. A negative association with DRw15 (DR2). Dw12 is also observed. The positive association with DPw3/6 RFLPs previously observed in White Australians is not present in South Indians. This difference may be due either to undetected heterogeneity within allelic classes or to different linkage disequilibrium patterns between the populations.

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HLA, complement C2, C4, properdin factor B and glyoxalase types in South Indian diabetics

Cited by 19 publications

References 21 publications

The genetic predisposition to fibrocalculous pancreatic diabetes

The genetic predisposition to fibrocalculous pancreatic diabetes

The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life

HLA‐DP, ‐DQ and ‐DR RFLP types in South Indian insulin‐dependent diabetes mellitus patients

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