HLA‐D locus in Israel. Characterization of 14 local HTC's and a population study

Abstract

Fourteen homozygous typing cells identified in Israel are described. Of these typing cells two were of Ashkenazi and 11 of non-Ashkenazi origin, while the remaining HTC was from an Arab donor. Ten of the 14 HTCs characterized in this manner were offspring of consanguineous marriages; all of them were non-Ashkenazim. Nine HTCs express specificities previously recognized in Caucasians, 4 HTCs represent new specificities (JI-J4), and one typing cell was found to be analogous to the Japanese Dw12 (DHO) specificity. The distribution of HLA-D specificities in 120 randomly selected Israelis representing the two main Jewish subpopulations, Ashkenazim and non-Ashkenazim, was studied with the locally defined HTCs. HLA-Dw5 and DwlO were found to be significantly increased while Dw2 and Dw6 were significantly decreased in Israelis as compared to Caucasians.

HLA‐D typing in Austria. A panel study using 26 newly defined homozygous typing cells

“…Antigen frequencies in our population are very similar to antigen frequencies in the north American Caucasians, excluding the high Dw5 and low Dw6 frequency in Austria. Elevated DR5 and Dw5 frequencies also are known from the Italian, Yugoslavian (Baur & Danilovs 1980), and the Israeli (Amar et al 1982) populations. This phenomenon, once more, underlines the south-eastem character of the principally middle European Austrian population.…”

HLA‐D “BG” in Israel

“…Thus, it is evident that HLA-Dwl2, recognized by a locally defined HTC (BGE) is also present in the Israeli population and has the same characteristics as the Japanese HTC (DHO) with regard to its association with alleles of the HLA-B,DR series. The frequency of this allele may partially account for the low frequency of HLA-Dw2 in the Israeli population (Amar et al 1982).…”

“…Caucasian homozygous typing cells (HTCs) (Amar et al 1982). Mean cpm values of each triplicate were fed into a computer and processed to stabilized relative response values (double .…”

Study of a family with Cerebrotendinous Xanthomatosis

“…Mixed lymphocyte culture (MLC) and HLA-D typing were performed using the standard MLC technique (Amar et al 1982). A selected panel of 30 European, American and local HTCs was employed to determine Dwl to Dw12 specificities.…”