HLA-DPB and susceptibility to hodgkins disease

Cesbron, Anne; Moreau, Philippe; Rapp, MJ; Cheneau, M.L.; Henry, Peter J.; Bonneville, Françoise; Muller, Jean‐Yves; Harousseau, J L; Bignon, Jean-Denis

doi:10.1016/0198-8859(93)90039-4

Human Immunology

1993

DOI: 10.1016/0198-8859(93)90039-4

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HLA-DPB and susceptibility to hodgkins disease

Anne Cesbron¹,

Philippe Moreau²,

MJ Rapp³

et al.

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“…A number of recent studies have suggested that alleles at the HLA-DPB1 locus, the most centromeric of the three major HLA class II loci (DR, DQ and DP), may increase susceptibility and resistance to HD. Thus, HLA-DPB1*0301 was found to be associated with susceptibility, and *0201 with resistance to HD (Bodmer et al, 1989;Tonks et al, 1992;Cesbron et al, 1993;Pellegris et al, 1993;Klitz et al, 1994;Oza et al, 1994).…”

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confidence: 99%

Further investigation of the role of HLA-DPB1 in adult Hodgkin’s disease (HD) suggests an influence on susceptibility to different HD subtypes

et al. 1999

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Summary It has been suggested in a number of studies that susceptibility to adult Hodgkin's disease (HD) is influenced by the HLA class II region, and specifically by alleles at the HLA-DPB1 locus. Since HD is diagnostically complex, it is not clear whether different HLA-DPB1 alleles confer susceptibility to different HD subtypes. To clarify this we have extended a previous study to type DPB1 alleles in 147 adult HD patients from a single centre. We have analysed patients with nodular sclerosing (NS), mixed cellularity (MC) or lymphocyte predominant (LP) HD, and gender in relation to HLA-DPBI type, in comparison with 183 adult controls. The results confirmed previously reported associations of DPB1*0301 with HD susceptibility (relative risk (RR) = 1.42; 95% confidence interval (CI) 0.86-2.36) and DPB1*0201 with resistance to HD (RR = 0.49; CI 0.27-0.90). However, analysis by HD subtype and gender showed that *0301-associated susceptibility was confined to females with HD (RR = 2.46; CI 1.02-5.92), and *0201-associated resistance to females with NS-HD (RR = 0.28; CI 0.10-0.79). Susceptibility to NS-HD was also associated in females with *1001 (RR = 11.73; CI 1.32-104.36), and resistance with *1101 (RR = 0.08; CI 0.01-0.65). In contrast, susceptibility to LP-HD was associated in males with *2001 (RR = 32.14; CI 3.17-326.17), and to MC-HD with *3401 (RR = 16.78; CI 2.84-99.17). Comparison of DPB1-encoded polymorphic amino-acid frequencies in patients and controls showed that susceptibility to MC-HD was associated with Leucine at position 35 of DPB1 (RR = 8.85; CI 3.04-25.77), and ). In contrast, Glutamic acid 69 was significantly associated with resistance to MC-HD (RR = 0.14; CI 0.03-0.60). Certain DPB1 alleles and individual DPβ1 polymorphic amino acid residues may thus affect susceptibility and resistance to specific HD subtypes. This may be through their influence on the binding of peptides derived from an HD-associated infectious agent, and the consequent effect on immune responses to the agent.

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Further investigation of the role of HLA-DPB1 in adult Hodgkin’s disease (HD) suggests an influence on susceptibility to different HD subtypes

et al. 1999

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Factors controlling in the concentration of gold and uranium in the Lower Carboniferous marl at Wadi El Kharig area, Southwestern Sinai, Egypt

Sallam

2020

Arab J Geosci

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HLA-DPB and susceptibility to hodgkins disease

Cited by 2 publications

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Further investigation of the role of HLA-DPB1 in adult Hodgkin’s disease (HD) suggests an influence on susceptibility to different HD subtypes

Further investigation of the role of HLA-DPB1 in adult Hodgkin’s disease (HD) suggests an influence on susceptibility to different HD subtypes

Factors controlling in the concentration of gold and uranium in the Lower Carboniferous marl at Wadi El Kharig area, Southwestern Sinai, Egypt

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