HLA-DQ Alleles Associate with Cutaneous Features of Onchocerciasis

Murdoch, Michele E.; Payton, Antony; Abiose, A; Thomson, Wendy; Panicker, Vinod Kumar; Dyer, Philip A.; Jones, Barrie R.; Maizels, Rick M.; Ollier, William

doi:10.1016/s0198-8859(97)00089-x

Cited by 31 publications

(10 citation statements)

References 19 publications

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“…We found a statistically significant decrease of the DR2 group in LCL patients, as was previously reported in MCL Brazilian patients [17], and recently found as a tendency in Mediterranean VL [18], this finding suggests that parasite peptides anchored to homologous DR2 group elicit a protective immune response and, thus, may also be candidates for the development of a vaccine. Several HLA alleles associated to susceptibility and protection in different populations, have been found in other parasitic diseases as malaria [32], onchocerciasis [33], hepatosplenic schistosomiasis [34], and alveolar echinococcosis [35], among others, indicating the complexity of the host-parasite interactions as well as the ethnic variability.…”

Section: Discussionmentioning

confidence: 99%

Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis

et al. 2004

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“…Onchocercal visual impairment (which included low vision and blindness) and depigmentation were found to concur significantly (OR 9.0, 95% CI 3.9–20.8), which was partly explained by age and exposure to infection (OR 3.0, 95% CI 1.2–7.7). Host immune characteristics such as the HLA-DQ alleles associated with depigmentation [ 24 ] might play a role in the pathogenesis of both depigmentation and visual impairment.…”

Section: Cutaneous Featuresmentioning

confidence: 99%

“…HLA class II variants may influence susceptibility to infection by O. volvulus and subsequent host immune responses causing pathology. Correlation between allelic variants of HLA-DQA1 and HLA-DQB1 and various forms of onchocercal skin disease have previously been documented in a Nigerian population [ 24 ], and recently a protective role of DQA1*0401 against O. volvulus infection has been demonstrated in both Cayapas Amerindians and Afro-Ecuadorians. Furthermore HLA-DQA1*0102 and *0103 seemed to represent risk factors for infection in Afro-Ecuadorians and HLA-DQA1*0301 was a possible susceptibility allele in the Cayapas population [ 44 ].…”

Section: Immunogeneticsmentioning

confidence: 99%

Onchodermatitis: Where Are We Now?

Murdoch

2018

TropicalMed

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Onchocerciasis causes debilitating pruritus and rashes as well as visual impairment and blindness. Prior to control measures, eye disease was particularly prominent in savanna areas of sub-Saharan Africa whilst skin disease was more common across rainforest regions of tropical Africa. Mass drug distribution with ivermectin is changing the global scene of onchocerciasis. There has been successful progressive elimination in Central and Southern American countries and the World Health Organization has set a target for elimination in Africa of 2025. This literature review was conducted to examine progress regarding onchocercal skin disease. PubMed searches were performed using keywords ‘onchocerciasis’, ‘onchodermatitis’ and ‘onchocercal skin disease’ over the past eight years. Articles in English, or with an English abstract, were assessed for relevance, including any pertinent references within the articles. Recent progress in awareness of, understanding and treatment of onchocercal skin disease is reviewed with particular emphasis on publications within the past five years. The global burden of onchodermatitis is progressively reducing and is no longer seen in children in many formerly endemic foci.

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“…Since this study was conducted, the skin classification scheme been successfully used in rain-forest onchocerciasis-endemic areas in Africa [23] as well as in a variety of mass drug treatment [24;25], psychosocial and economic [26–28], genetic [29] and immunological studies [30;31]. …”

Section: Discussionmentioning

confidence: 99%

“…There is a spectrum of immune response to infection, with some infected persons showing a minimal immune response to parasite antigens, allowing the proliferation of microfilariae in the absence of clinical symptoms, while others have an intact and symptomatic immune response [38]. An immunogenetic basis for this clinical spectrum has been suggested [29;39;40] and differing isotypic antibody responses [30] and cellular immune responses [31;41–45] may play a role. The endosymbiotic bacteria Wolbachia are essential for the pathogenesis of O .…”

Section: Discussionmentioning

confidence: 99%

Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria

Murdoch

Evans

et al. 2017

PLoS Negl Trop Dis

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BackgroundOnchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness.MethodsA clinical classification system of the cutaneous changes in onchocerciasis was used for the first time in this study within the context of an early ivermectin drug trial in the savanna region of Kaduna State, northern Nigeria. Skin examinations were performed in 6,790 individuals aged 5+ years in endemic communities and 1,343 individuals in nonendemic communities.Results / DiscussionThere was increased risk for all forms of onchocercal skin disease in endemic communities with the most common finding being the presence of nodules (1,438 individuals, 21.2%), followed by atrophy (367, 6.1% of those < 50 years), acute papular onchodermatitis, APOD (233, 3.4%), depigmentation (216, 3.2%) and chronic papular onchodermatitis, CPOD (155, 2.3%). A further 645 individuals (9.5%) complained of pruritus but had completely normal skin. APOD was more common in males whereas atrophy, hanging groin and nodules were more common in females. After controlling for age and sex, microfilarial positivity was a risk factor for CPOD, depigmentation, hanging groin and nodules (OR 1.54, p = 0.046; OR 2.29, p = 0.002; OR 2.18, p = 0.002 and OR 3.80, p <0.001 respectively). Comparable results were found using presence of nodules as the marker for infection. Microfilarial load showed similar, though weaker, results. A total of 2621(38.6%) endemic residents had itching with normal skin, or had one or more types of onchocercal skin disease including nodules, which may be considered as a composite index of the overall prevalence of onchocercal skin disease.ConclusionSignificant levels of onchocercal skin disease were documented in this savanna area, which subsequently resulted in a reassessment of the true burden of skin disease in onchocerciasis. This paper represents the first detailed report of the association of onchocercal skin disease with markers for onchocercal infection.

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HLA-DQ Alleles Associate with Cutaneous Features of Onchocerciasis

Cited by 31 publications

References 19 publications

Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis

Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis

Onchodermatitis: Where Are We Now?

Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria

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