HLA-DQ genetic risk gradient for type 1 diabetes and celiac disease in north-western Mexico

Mejía-León, María Esther; Ruiz-Dyck, K.M.; Barca, Ana María Calderón de la

doi:10.1016/j.rgmxen.2015.03.005

Cited by 11 publications

(7 citation statements)

References 44 publications

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“…This explanation was supported by a study by DiGiacomo et al., 24 who found that 29% had DQ2.5/8, but the figure rose to 39% when counting the total HLA DQ2/8. When counting only HLA DQ2.5 cis and DQ8 the percentages in our study were: DQ2.5cis: 25% (572/2293), DQ8: 16% (361/2293), and 2.5 cis and/or DQ8: 41% (933/2293), comparable to the 22% among the control group in a Swedish study for DQ2.5, 26 but higher for DQ8 than numbers from Mexico and Brazil 27 , 28 . Compared with the prevalence table of different populations in Alarida et al., 29 our numbers are higher for DQ2 (DQ2:31%/DQ2.5 25% vs 23%), but comparable for DQ8 (DQ8 16% vs 28.3%), and the Scandinavian numbers from the table (11% DQ2 and 15% DQ8) are lower than ours.…”

Section: Discussionsupporting

confidence: 60%

“…When counting only HLA DQ2.5cis and DQ8 the percentages in our study were: DQ2.5cis: 25% (572/2293), DQ8: 16% (361/2293), and 2.5cis and/or DQ8: 41% (933/ 2293), comparable to the 22% among the control group in a Swedish study for DQ2.5, 26 but higher for DQ8 than numbers from Mexico and Brazil. 27,28 Compared with the prevalence table of different populations in Alarida et al, 29 our numbers are higher for DQ2 (DQ2:31%/DQ2.5 25% vs 23%), but comparable for DQ8 (DQ8 16% vs 28.3%), and the Scandinavian numbers from the table (11% DQ2 and 15% DQ8) are lower than ours. Our HLA DQ2/8 prevalence is also higher than the one found in a screening study from Latvia comparable to our study.…”

Section: Discussioncontrasting

confidence: 51%

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The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population

et al. 2018

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Background: Human leukocyte antigen (HLA) DQ2 and DQ8 are important risk factors for some autoimmune diseases such as celiac disease (CD), but their possible role in other diseases and health conditions is not fully explored. Objectives: The objective of this article is to examine the distribution of HLA DQ2 and HLA DQ8 in an adult general population, and their association with health indicators (diseases, symptoms and biomarkers). Methods: In this cross-sectional, population-based study, 2293 individuals were screened for HLA DQ2 and DQ8; CDassociated alleles (DQA*0201*03*05/DQB*02*0301/0304*0302/0305) and DQB1*02 homozygosity were determined for screen-positive participants. The National Patient Registry provided diagnosis information. Results: A total of 47.7% (1093/2293) individuals were positive for DQ2 and/or DQ8: 31.2% (716/2293) only DQ2, 11.9% (273/ 2293) only DQ8, 4.1% (93/2293) both DQ2 and DQ8. Among nine individuals diagnosed with CD, 89.9% (8/9) had DQ2.5cis, 22.2% (2/9) DQ8 and 22.2% (2/9) DQ2.2 (two both DQ2 and DQ8). HLA DQ2.5 was associated with higher thyroid-stimulating hormone levels, while DQ2/DQ8-positive participants had significantly lower prevalence of irritable bowel syndrome (IBS). DQ2/DQ8 were strongly associated with CD, but no other registry-based diagnoses. Conclusion: In this general Danish population, 47.7% were HLA DQ2/DQ8 positive and thus potentially at risk for CD. All individuals with CD were DQ2/DQ8 positive; the majority DQ2.5. Surprisingly, DQ2/DQ8-positivity was associated with lower IBS prevalence. KeywordsCeliac disease, HLA DQ2, HLA DQ8, epidemiology Received: 29 December 2017; accepted: 21 February 2018 Key summary 1. Summarize the established knowledge on this subject:. Celiac disease is a lifelong autoimmune disease caused by a harmful immune response to gluten proteins in genetically susceptible individuals. . Human leukocyte antigen (HLA) DQ2 and HLA DQ8 are important risk factors for some autoimmune diseases such as celiac disease; however, their possible role in other diseases and health conditions is not fully explored. 2. What are the significant and/or new findings of this study? . Our study showed that 47.7% of individuals were HLA DQ2/DQ8 positive and thus potentially at risk for celiac disease in this general Danish population. . We found that all individuals with celiac disease were HLA DQ2/DQ8 positive; the majority DQ2.5. . Furthermore, HLA DQ2/DQ8 positivity was associated with lower prevalence of irritable bowel syndrome, but not with other diagnoses/diseases.

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Section: Discussionsupporting

confidence: 60%

Section: Discussioncontrasting

confidence: 51%

The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population

et al. 2018

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“…When comparing our population with another Latin‐American country as Mexico, we found a slightly increased frequency of CD HLA‐DQ predisposing variants in our population (43.7% vs. 28.8%). However, authors did not consider DQ2.2 in the Mexican study (Mejía‐León, Ruiz‐Dyck, & Calderón de la Barca, ). An unexpectedly high prevalence of this HLA‐DQ genotypes (55.9%) was reported in a recent study from Australia.…”

Section: Discussionmentioning

confidence: 99%

Frequency of HLA‐DQ, susceptibility genotypes for celiac disease, in Brazilian newborns

Almeida

Gandolfi

Costa

et al. 2018

Molec Gen & Gen Med

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BackgroundThe frequency of HLA‐DQ2 and DQ8 predisposing genotypes for celiac disease (CD) has shown significant variation among different world regions and has not been previously determined among the highly interbred Brazilian population. The aim of this study was to investigate the frequency of these genotypes among Brazilian newborns (NB).MethodsWe typed DQA1*05 ‐ DQB1*02 (DQ2.5) and DQA1*03 ‐ DQB1*03:02 (DQ8) alleles in 329 NB using qPCR technique. Subsequently we confirmed our results by PCR‐SSP using a reference kit which further identified DQ2.2 (DQA1*02:01 ‐ DQB1*02).ResultsAmong the 329 NB, using qPCR technique: 5 (1.52%) carried both DQ2.5 and DQ8 variants; 58 (17.63%) carried only DQ2.5 (DQA1*05 and DQB1*02) and 47 (14.29%) carried only the DQ8 (DQA1*03 and DQB1*03:02) variant. The use of the PCR‐SSP method yielded further information; among the 329 samples: 34 (10.34%) tested positive for DQ2.2 and among the 47 previously DQ8 positives samples, we found 10 (3.04%) that also tested positives for DQ2.2.Conclusion43.7% of the analyzed individual tested positive for at least one of the CD predisposing HLA‐DQ genotypes in our group of Brazilian NB. The highest frequency was found for DQ2.5 positive subjects (17.6%) followed by DQ8 (11.3%); DQ2.2 (10.3%); DQ8 and DQ2.2 (3.0%); DQ2.5 and DQ8 (1.5%). We found no positive sample for DQ2.5 associated with DQ2.2.

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“…Diabetes Mellitus (DM) is a diffuse endocrine disease, characterized by metabolic abnormalities and long-term complications due to hyperglycemia. Approximately 30% of all newborn children have the genetic risk for type 1 DM and a smaller percentage of those children progress to the clinical disease (Mejía-León et al, 2015). Additional factors are also involved in type 1 DM pathogenesis, such as viral infections, intestinal inflammation, and nutritional factors, which are required to trigger the disease in genetically predisposed individuals (Kinip, Simell, 2012).…”

Section: Introductionmentioning

confidence: 99%

Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

Medeiros

Pereira

Silva

et al. 2020

Braz. J. Pharm. Sci.

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HLA-DQ genetic risk gradient for type 1 diabetes and celiac disease in north-western Mexico

Cited by 11 publications

References 44 publications

The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population

The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population

Frequency of HLA‐DQ, susceptibility genotypes for celiac disease, in Brazilian newborns

Ethanol extract of Cissampelos sympodialis ameliorates lung tissue damage in streptozotocin-induced diabetic rats

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