HLA-DQB1 *03 and cervical intraepithelial neoplasia grades I-III

Vandenvelde, C.; Foor, Marc De; Beers, Danielle Van

doi:10.1016/0140-6736(93)93044-2

Cited by 37 publications

(16 citation statements)

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“…An increased frequency of HLA-DQw3 alleles associated with cervical carcinoma has been observed in Germany' and N~r w a y ,~ while a similar association has not (7,8,9) 49.4 93.6 DQw4…”

Section: Discussionmentioning

confidence: 75%

Association of human leukocyte antigen-B1*03 with cervical cancer in Japanese women aged 35 years and younger

Nawa

Nishiyama

Kobayashi³

et al. 1995

Cancer

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Background. An association of human leukocyte antigen (HLA)‐DQw3 alleles with squamous cell carcinoma (SCC) of the cervix has been reported in some European populations, but the significance of HLA‐DQw3 has not been examined in other populations to the authors' knowledge. The interaction between HLA‐DQw3 and human papillomavirus (HPV) in SCC remains to be clarified. Methods. To elucidate the association of HLA‐DQ alleles with SCC of the cervix, DNA samples extracted from blood lymphocytes of 23 patients with SCC were amplified by the polymerase chain reaction (PCR) using specific primers for the DQB1 genes, and then, each HLA‐DQB1 genotype was defined by digestion with restriction enzymes. Human papillomavirus typing also was performed in all cases by PCR, using specific primers for the E6 regions of cancer‐associated HPV types (HPV 16, 18 and 33). Results. Twenty patients (87%) carried a DQB1 geneencoding HLA‐DQw3, compared with 49.4% Japanese control subjects in the International Histocompatibility Workshop panel (P ‐ 0.0003). Human papillomavirus 16 or HPV 18 DNA was detected in 86% of the patients. In 13 of the patients with invasive carcinoma with HPV, a high incidence of not only HLA‐DQw3 but also of HLA‐DQw1 was observed compared with that in control subjects (P = 0.0019, P = 0.047, respectively). The correlation between DQB1*03 alleles and HPV infection was not statistically significant. Conclusion. The frequency of HLA‐DQw3 alleles was higher in the authors' patient group than in the control group, suggesting that the HLA‐DQw3 molecules may influence the development of SCC of the cervix in young Japanese women. In the patients with HPV‐positive invasive carcinoma, the association with HLA‐DQw1 molecules suggested that it also may influence the progression of SCC. Cancer 1995;75:518‐21.

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“…An increased frequency of HLA-DQw3 alleles associated with cervical carcinoma has been observed in Germany' and N~r w a y ,~ while a similar association has not (7,8,9) 49.4 93.6 DQw4…”

Section: Discussionmentioning

confidence: 75%

Association of human leukocyte antigen-B1*03 with cervical cancer in Japanese women aged 35 years and younger

Nawa

Nishiyama

Kobayashi³

et al. 1995

Cancer

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“…[10–121543485158] Only a few studies investigated the DO and DP genes and reported a positive association with severity of the disease with both the DOB1*03 and DPB1 genes. [405960]…”

Section: Methodsmentioning

confidence: 99%

A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer

Chattopadhyay¹

2011

Indian J Hum Genet

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Cervical cancer is the second most common cancer in women worldwide. This is caused by oncogenic types of human papillomavirus (HPV) infection. Although large numbers of young sexually active women get HPV-infected, only a small fraction develop cervical cancer. This points to different co-factors for regression of HPV infection or progression to cervical cancer. Host genetic factors play an important role in the outcome of such complex or multifactor diseases such as cervical cancer and are also known to regulate the rate of disease progression. The aim of this review is to compile the advances in the field of host genetics of cervical cancer. MEDLINE database was searched using the terms, ‘HPV’, ‘cervical’, ‘CIN’, ‘polymorphism(s)’, ‘cervical’+ *the name of the gene* and ‘HPV’+ *the name of the gene*. This review focuses on the major host genes reported to affect the progression to cervical cancer in HPV infected individuals.

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“…To date, most research efforts have focused on the association of HLA, specifically, certain class II alleles, with cervical intraepithelial neoplasia (David et al, 1992;Vandenvelde et al, 1993;Apple et al, 1995;Odunsi et al, 1995Odunsi et al, , 1996Bontkes et al, 1998;Hildesheim et al, 1998;Krul et al, 1999b;Beskow et al, 2001;Wang et al, 2001) and cancer risk (Wank and Thomssen, 1991;Apple et al, 1994;Gregoire et al, 1994;Allen et al, 1996;SastreGarau et al, 1996;Cuzick et al, 2000;Neuman et al, 2000). However, with few exceptions, strong population-independent associations with specific HLA types have been elusive because of a linkage disequilibrium observed in the HLA gene cluster and the probable presence of several polymorphic immune-related genes inside and outside the HLA region that could influence the outcome of the viral infectious processes (Gostout et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Loss of heterozygosity on chromosome 6 in HPV‐16 positive cervical carcinomas carrying the DRB11501‐DQB10602 haplotype

Arias-Pulido

Joste

Wheeler

2004

Genes Chromosomes & Cancer

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High-risk human papillomaviruses (HPVs), specifically HPV-16 and -18, have been associated with the development of carcinoma in situ (CIS) and of invasive cervical cancer (CC). However, only a small fraction of HPV-infected women will show signs of disease progression, suggesting that other factors in the carcinogenic pathway are needed. We previously demonstrated that human leukocyte antigen (HLA) DRB1*1501-DQB1*0602 (high risk) was associated with the development of CIS and CC tumors in HPV-16-positive patients. To characterize the molecular changes that could be relevant to tumor progression, we compared the extent of loss of heterozygosity (LOH) on chromosome 6 in HPV-16-positive CIS patients who were carriers of high-risk and neutral HLA haplotypes. CIS and CC cases demonstrated similar LOH patterns. A wide range of LOH frequencies was found at 6p (10-53%) and 6q (5-28%) in CIS cases, suggesting that LOH is an early event in the carcinogenic process. A comparative analysis of LOH frequencies in the high-risk versus the neutral HLA haplotypes showed a statistically significant difference in the extent of LOH at 6p24-p25 (58.6% versus 25.8%; P = 0.018) and at 6p21.3 (79.3% versus 35.5%; P = 0.001), a region that contains the HLA complex. LOH at this region could affect genes encoding HLA class I-II molecules, as well as factors responsible for the assembly, transport, and stable expression of HLA molecules. These losses may be a reflection of both an abnormal immune response and a general genome-wide instability resulting from virus persistence.

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HLA-DQB1 *03 and cervical intraepithelial neoplasia grades I-III

Cited by 37 publications

References 4 publications

Association of human leukocyte antigen-B1*03 with cervical cancer in Japanese women aged 35 years and younger

Association of human leukocyte antigen-B1*03 with cervical cancer in Japanese women aged 35 years and younger

A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer

Loss of heterozygosity on chromosome 6 in HPV‐16 positive cervical carcinomas carrying the DRB11501‐DQB10602 haplotype

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HLA-DQB1 *03 and cervical intraepithelial neoplasia grades I-III

Cited by 37 publications

References 4 publications

Association of human leukocyte antigen-B1*03 with cervical cancer in Japanese women aged 35 years and younger

Association of human leukocyte antigen-B1*03 with cervical cancer in Japanese women aged 35 years and younger

A comprehensive review on host genetic susceptibility to human papillomavirus infection and progression to cervical cancer

Loss of heterozygosity on chromosome 6 in HPV‐16 positive cervical carcinomas carrying the DRB1*1501‐DQB1*0602 haplotype

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Loss of heterozygosity on chromosome 6 in HPV‐16 positive cervical carcinomas carrying the DRB11501‐DQB10602 haplotype