HLA-DQw1 COMPATIBILITY AND CADAVERIC RENAL ALLOGRAFT SURVIVAL

Sengar, D. P. S.; Couture, R. A.; Raman, Sankaranarayanan; Jindal, S. L.

doi:10.1097/00007890-199007000-00029

Cited by 5 publications

(2 citation statements)

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“…whereas DOz and DOJ did not influence graft prognosis [7]. In this study, however, D01 compatibility involved both identity (D + R +)and D01 recipients ofD0 1 -negative kidneys (D-R+); splits of DO~o DOs and D0 6 were not studied.…”

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confidence: 56%

“…but not on DO molecules [9]. However, the recent demon~tration of the prominent role of DO as immune response molecules in diseases such as type I diabetes mellitus [10] opens the debate for a role of those antigens in transplantation, a hypothesis already put forward by Duquesnoy et al [3] and more recently by Sengar et al [7]. Assuming that the model proposed for class II molecules and applied for antigen presentation [2] is valid for alloreactivity, we are currently studying amino acid homologies on the top of the groove formed by the a1 and ~~ chains of DO molecules.…”

Section: Discussionmentioning

confidence: 99%

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Detrimental role of donor-recipient HLA-DQ5 and -DQ6 disparities on cadaver kidney graft survival

Vereerstraeten

Andrien

Dupont

et al. 1992

Transplant International Official Journal of the European Society for Organ Transplantation

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Donor-recipient incompatibility (D + R-) for HLA-001, but not for-DOz or-D03, is associated with an adverse effect on cadaver kidney graft survival. Until now, however, 001 recipients of D01-negative kidneys (D-R +) have not been differentiated from D01-identical donor-recipient pairs (D + R +)and splits of D01. DOs and 006, have not been studied in that respect. From our data ( 480 transplantations performed from January 1980 to December 1990), three donor-recipient DO combinations (D + R + , D -R + , D + R -) were formed for each of four DO specificities (DOz. DOJ. DOs. 006). As DR-DO linkage disequilibrium is well conserved in caucasoid individuals, DO specificities were inferred from the associated DR specificities. Graft survival rate (%) was significantly lower for the DOs D + R-and the D06 D -R + combinations when compared with the other corresponding DO combinations, whereas no significant difference was observed between the DOz and DOJ combinations. In conclusion, if D01 plays a prominent role in kidney graft survival, the effects of its splits appear dissociated: 005 could be a marker of high antigenicity and D06 a marker of high responsiveness.In previous retrospective [I 1] and prospective [12] studies from our centre, donor-recipient HLA-DR disparities characterized by the presence of the antigen in the donor but not in the recipient, or vice-versa, were shown to affect cadaver kidney graft survival differentially. Some of those disparities were beneficial (DR4, DRS and DR7 in the donor; DRS in the recipient) whereas others were detrimental (DR1 and DR2 in the donor: DR2, DRW6 and Offprint requests to:

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confidence: 56%

Section: Discussionmentioning

confidence: 99%

Detrimental role of donor-recipient HLA-DQ5 and -DQ6 disparities on cadaver kidney graft survival

Vereerstraeten

Andrien

Dupont

et al. 1992

Transplant International Official Journal of the European Society for Organ Transplantation

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The Influence of HIA and ABO Antigens on Graft Rejection and Survival

Sanfilippo

1991

Clinics in Laboratory Medicine

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The Impact of Hla-a Matching on Long-Term Survival of Renal Allografts

Zantvoort

D’Amaro²,

Persijn

et al. 1996

Transplantation

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An important contribution of HLA-A antigen matching in renal transplantation was reported initially, hut later publications showed a minor or absent role. We analyzed the contribution of HLA-A locus matching to graft survival in 17,672 first renal transplants from unrelated, nonliving donors. We show that an independent HLA-A matching effect still exists. Due to its relative weakness and late appearance, large numbers and longer follow-up periods are required. The HLA-A matching effect is a significant factor in first renal allograft survival up to 6 years after transplantation, with an increasing effect over time. This is in contrast to the strong, short-lived, effects of HLA-DR and -B matching, which can only be detected up to 6 months and 2 years after transplantation, respectively. A clear additive beneficial effect of HLA-A matching is shown in the group without B and DR mismatches. Therefore, prospective matching for the HLA-A antigens remains important for renal allograft survival.

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HLA-DQw1 COMPATIBILITY AND CADAVERIC RENAL ALLOGRAFT SURVIVAL

Cited by 5 publications

References 0 publications

Detrimental role of donor-recipient HLA-DQ5 and -DQ6 disparities on cadaver kidney graft survival

Detrimental role of donor-recipient HLA-DQ5 and -DQ6 disparities on cadaver kidney graft survival

The Influence of HIA and ABO Antigens on Graft Rejection and Survival

The Impact of Hla-a Matching on Long-Term Survival of Renal Allografts

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