HLA-DR/DQ Genotypes in Kurd Patients with Rheumatoid Arthritis: Relation to Disease Activity

Al-Timimi, Dhia J.; Rasool, Mohammad; Sulaiman, Dhia Mustafa

doi:10.7860/jcdr/2014/8112.4349

Cited by 9 publications

(9 citation statements)

References 13 publications

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“…This study has revealed an association of HLA‐DRB1 *01, *04, *10 and *14 with patients suffering from RA. HLA‐DRB1 *01 alleles were associated with RA proneness in Mexican, Syria, Finnish, Japanese, Italians, French, Kurd and Turkish populations . HLA‐DRB1 *04 was significantly associated in RA patients in north India, Pakistan and Syria, but there were no significant correlations between DRB1 *04 and RA susceptibility in Peruvian and Mexican American populations .…”

Section: Discussionmentioning

confidence: 97%

HLA‐DRB1shared epitope alleles in patients with rheumatoid arthritis: relation to autoantibodies and disease severity in a south Indian population

et al. 2016

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Section: Discussionmentioning

confidence: 97%

HLA‐DRB1shared epitope alleles in patients with rheumatoid arthritis: relation to autoantibodies and disease severity in a south Indian population

et al. 2016

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“…Out of 41 patients diagnosed radiologically and clinically presenting with signs and symptoms of ankylosing spondylitis, 27 patients (65.9%) had the HLA-B*27 allele (P < 0.00001). Of these, 23 were male (88.5%) and four were female (11.5%), the male-to-female ratio being 5.8 : 1, while in those patients who did not have the HLA-B*27 allele the ratio was 3.7 : 1 ( Table 1) (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19), this delay in diagnosis was longer in HLA-B*27 negative patients (6.5 years) (range 6-19 years). The average of total duration of the disease was 6.7 years (range 2-9) and was longer in HLA-B*27 positive patients (6.8 years) (range 1-7 years).…”

Section: Hla-b*27 In Ankylosing Spondylitis Patientsmentioning

confidence: 99%

“…6,[9][10][11][12] Although studies demonstrating the association of HLA-B*27 and ankylosing spondylitis have been done in different populations, [13][14][15][16][17][18] not much research into the association of HLA and diseases has been conducted in the Kurdistan Region of Iraq. 19 In this retrospective study, we aim to estimate the prevalence of HLA-B*27 in the healthy population, and its association with ankylosing spondylitis in Kurdish patients.…”

Section: Introductionmentioning

confidence: 99%

Association ofHLA‐B*27 with ankylosing spondylitis in Kurdish patients

et al. 2015

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“…Whole blood was collected in Ethylene Diamine Tetra Acetic Acid (EDTA) tubes for MTHFR gene polymorphisms study. Another volume of blood was collected in a gel tube, for laboratory investigations involving MTX blood level, Anti cyclic citrullinated peptide (ACCP), C-reactive protein (CRP), and Homocysteine (Hcys) [22][23]. Human Methotrexate ELISA KIT (Bioassay Technology Laboratory, China) was used for the determination of MTX serum level (Bio-Tek reader, USA).…”

Section: Metabolite Analysismentioning

confidence: 99%

MTHFR Gene Polymorphisms in Iraqi Kurdish Rheumatoid Arthritis Patients: Relation to Methotrexate Response and Toxicity

Younis

Issa²,

Sulaiman³

2022

Iraqi Journal of Science

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Methotrexate (MTX) is still one of the gold standard treatments for rheumatoid arthritis (RA). It shows diverse outcomes in blood level and clinical response, this was demonstrated by its relation to the genetic polymorphism in the pharmacogenetic study. This study aimed to investigate the role of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in relation to MTX efficacy and toxicity in Iraqi Kurdish RA patients. Sixty-four RA patients were involved in this study with an average age of 47.78 ±14.08 and female to male ratio of (8.1). Diagnosis and disease activity were confirmed. Blood analyses, including those of laboratory markers of disease activity, were done. The 28 joint disease activity score (DAS28-CRP) was calculated. MTHFR gene polymorphisms were analyzed by real-time polymerase chain reaction. The most frequent genotypes which were identified in RA patients were the CT genotype of the C677T single nucleotide polymorphism (SNP) (51.6%) and the AC genotype of the A1298C SNP (48.4%). Patients with non-response to treatment had high frequencies of genotypes CT and TT (58.0% and 12.0%) of the C677T SNP respectively, as compared to those in the responder group; 28.6% and 0.0%); T-allele was associated with drug non-responding OR=4.17, P value=.0.009, meanwhile; genotypes AC and CC of the A1298C SNP were seen in (54.0% and 16.0%) in non-responder group. Patients with active RA had increased frequencies of CT and TT genotypes of the C677T SNP (60.0% and16.0%) respectively as compared to those who were in remission (26.6% and 0.0%); T-allele was associated with high disease activity; OR = 5.11. No association was found between C677T SNP and A1298C SNP, and MTX level status (P> 0.05). However, the variant alleles (T and C) were associated with the MTX toxic level (OR: 2.05, 95% CI [0.97 – 4.32]) and (OR: 1.99, 95% CI [0.96 – 4.18]) respectively. This study suggests that genetic polymorphisms of MTHFR SNP (C677T and A1298C) are associated with MTX efficacy but not toxicity in RA patients. This may assist the physicians in personalizing RA treatment in Iraqi patients.

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HLA-DR/DQ Genotypes in Kurd Patients with Rheumatoid Arthritis: Relation to Disease Activity

Cited by 9 publications

References 13 publications

HLA‐DRB1shared epitope alleles in patients with rheumatoid arthritis: relation to autoantibodies and disease severity in a south Indian population

HLA‐DRB1shared epitope alleles in patients with rheumatoid arthritis: relation to autoantibodies and disease severity in a south Indian population

Association ofHLA‐B*27 with ankylosing spondylitis in Kurdish patients

MTHFR Gene Polymorphisms in Iraqi Kurdish Rheumatoid Arthritis Patients: Relation to Methotrexate Response and Toxicity

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