HLA-DR-DQ haplotypes and type 1 diabetes in Macedonia

Ilonen, Jorma; Kočova, Mirjana; Lipponen, Kati; Sukarova-Angelovska, Elena; Jovanovska, Aleksandra; Knip, Mikael

doi:10.1016/j.humimm.2009.03.014

Cited by 14 publications

(15 citation statements)

References 19 publications

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“…It is noteworthy that DQB1*0201/DQB1*0302 gave the highest association with T1DM in Saudi patients (38.8%, OR ϭ 18.4), similar to findings in the United States [35], Finland [36], Hungary [37], and Romania [38].…”

Section: Discussionsupporting

confidence: 82%

Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes

Manan¹,

Angham²,

Awadalla³

2010

Human Immunology

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Section: Discussionsupporting

confidence: 82%

Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes

Manan¹,

Angham²,

Awadalla³

2010

Human Immunology

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“…The HLA-DR and -DQ genes are well established as being associated with increased risk for T1DM. The lowest incidence of childhood T1DM in Europe has been reported from the Republic of Macedonia (15). Similar disease associations were found in other Caucasian populations.…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of T1DM is rapidly increasing in specific regions and shows a trend toward earlier age of onset and also it is highly variable among different ethnic groups (6,7,8,9,10,11,12,13,14,15). It is predicted that the overall incidence of T1DM is about 40% higher in recent years as compared to its incidence in 1997 (16).…”

Section: Discussionmentioning

confidence: 99%

“…T1DM is an autoimmune disorder and the risk for the disease is increased by specific HLA DR/DQ alleles [e.g., DRB1*03-DQB1*0201 (DR3) or DRB1*04-DQB1*0302 (DR4)] (2,3,4,5). Trends in the frequency of HLA DR-DQ haplotypes showed different associations in distinct ethnic groups (6,7,8,9,10,11,12,13,14,15) and also in the same region (11). With these variations in mind, T1DM patients and healthy controls from the population of the Southeast Region of Turkey were investigated for HLA DR-DQ haplotypes.…”

Section: Introductionmentioning

confidence: 97%

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Trends in the Frequency of HLA DR-DQ Haplotypes Among Children and Adolescents with Type 1 Diabetes Mellitus in the Southeast Region of Turkey

Keskın¹,

Aygün²,

Pehlivan³

et al. 2012

Jcrpe

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Objective: The aim of this study was to determine the frequency of HLA DR-DQ haplotypes in children with type 1 diabetes mellitus (T1DM) in the Southeast Region of Turkey.Methods: Eighty children and adolescents with T1DM and eighty control subjects participated in the study. HLA-DR, DQ was typed using polymerase chain reaction and sequence-specific priming technique.Results: HLA DRB1*03 allele was significantly more common in patients than in control subjects. HLA DRB1*11, HLA DRB1*13 and HLA DRB1*14 allele frequencies were significantly lower in patients than in controls. DQB1*02 allele was more common in patients, whereas DQB1*03 allele was more frequent in control subjects. HLA DRB1*03-DQB1*02 haplotype was more frequently observed among patients.Conclusion: These results confirm the similar potential trends in the frequency distribution of HLA susceptibility genes with T1DM previously observed in Turkey and in other Caucasian populations. Conflict of interest:None declared.

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“…These studies have clarified the natural history of diabetes-associated autoimmunity and have also included prevention trials aiming at either primary prevention, such as TRIGR, or secondary prevention, in which delay of disease development is aimed at subjects with diabetes-associated autoantibodies [34,[46][47][48][49][50]. The haplotypes associated with disease susceptibility and protection are relatively constant between various Caucasian populations, although their relative frequency is very variable [51]. Typing for DR-DQ haplotypes associated with either disease risk or protection against disease can be often made by determination of either a single locus or two loci because of the extremely strong linkage disequilibrium between the alleles.…”

Section: Genetic Prediction Of T1dmentioning

confidence: 99%

Novel Gene Associations in Type 1 Diabetes

Ilonen

Hermann

2010

Curr Diab Rep

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Recent genome-wide association studies have been able to identify multiple new gene loci affecting type 1 diabetes susceptibility, but the impact of these new defined loci seems to decrease in parallel with their number. The HLA gene region remains the main nominator of genetic susceptibility, although the identity of important genes and especially the mechanisms of their action are still largely unclear. Products of HLA and most other known risk genes are involved in regulation of the immune system in accordance with the autoimmune nature of the disease. The multitude of genes involved in the pathogenesis implies complex pathways where multiple steps in each may be essential in turning the balance of immune response to beta-cell destructing autoimmunity.

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HLA-DR-DQ haplotypes and type 1 diabetes in Macedonia

Cited by 14 publications

References 19 publications

Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes

Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes

Trends in the Frequency of HLA DR-DQ Haplotypes Among Children and Adolescents with Type 1 Diabetes Mellitus in the Southeast Region of Turkey

Novel Gene Associations in Type 1 Diabetes

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